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Health Regulating Effects and Food-Related Functional Properties of Bioactive Food-Derived Peptides

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: closed (1 December 2022) | Viewed by 1729

Special Issue Editors


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Guest Editor
Department of Food Science, College of Agriculture, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 40704, Taiwan
Interests: enzymology; biochemistry; molecular biology; applied microbiology

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Guest Editor
Department of Food Science, College of Agriculture, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 40704, Taiwan
Interests: enzymatic hydrolysis of proteins; functional peptides; bioreactor; ultrafiltration membrane; identification of bioactive peptides; study of bioactive mechanism

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Guest Editor
Departemen Ilmu dan Teknologi Pangan, Fakultas Teknologi Pertanian, Institut Pertanian Bogor, Bogor, Indonesia
Interests: membrane separation; functional food; bioactive peptides; food process engineering

Special Issue Information

Dear Colleagues,

Food-derived bioactive peptides are broadly used as valuable ingredients in health-regulating supplements, as well as thanks to their food-related functional properties such as their emulsifying ability, foam stabilization, water-holding capacity, etc. Previous studies on protein enzymatic hydrolysates initially focused on improving dietary and nutritional functions, for example, helping human gut intestinal systems absorb small peptides (dipeptide or tripeptide) better than free amino acids. Nowadays, food proteins from plants, animals, and even agricultural byproducts are great sources for obtaining bioactive peptides, showing functions of antimicrobial, antioxidation, antithrombotic, stimulating lipolysis, antiangiotensin I-converting enzyme activity, immunomodulatory effects, etc. In general, bioactive peptides are 3-20 amino acids in length, showing valuable applications as food additives, nutraceuticals, and even pharmaceuticals. Bioactive peptides can promote human health by attenuating chronic diseases owing to the modulation and improvement of the physiological functions of the human body.

In this Special Issue, we welcome manuscripts regarding the obtainment of bioactive peptides from food resources and, further, their purification through the use of innovative methods such as membrane technology. In addition, bioactive peptides synthesized by microbial biotechnologies are also welcome.

Dr. Lu-Sheng Hsieh
Dr. Wen-Dee Chiang
Dr. Azis Boing Sitanggang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive peptides
  • protein hydrolysate
  • food innovative technology
  • membrane technology
  • purification and characterization
  • functional food

Published Papers (1 paper)

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Research

12 pages, 2823 KiB  
Article
The SWGEDWGEIW from Soybean Peptides Reduce Oxidative Damage-Mediated Apoptosis in PC-12 Cells by Activating SIRT3/FOXO3a Signaling Pathway
by Guofu Yi, Mengyue Zhou, Qingfei Du, Shuibing Yang, Yuxia Zhu, Yining Dong, Yang Liu, He Li, You Li and Xinqi Liu
Molecules 2022, 27(21), 7610; https://doi.org/10.3390/molecules27217610 - 6 Nov 2022
Cited by 2 | Viewed by 1334
Abstract
The goal of the investigation was to study the protective effects of the SWGEDWGEIW (the single peptide, TSP) from soybean peptides (SBP) on hydrogen peroxide (H2O2)-induced apoptosis together with mitochondrial dysfunction in PC-12 cells and their possible implications to [...] Read more.
The goal of the investigation was to study the protective effects of the SWGEDWGEIW (the single peptide, TSP) from soybean peptides (SBP) on hydrogen peroxide (H2O2)-induced apoptosis together with mitochondrial dysfunction in PC-12 cells and their possible implications to protection mechanism. Meanwhile, the SBP was used as a control experiment. The results suggested that SBP and TSP significantly (p < 0.05) inhibited cellular oxidative damage and ROS-mediated apoptosis. In addition, SBP and TSP also enhanced multiple mitochondrial biological activities, decreased mitochondrial ROS levels, amplified mitochondrial respiration, increased cellular maximal respiration, spare respiration capacity, and ATP production. In addition, SBP and TSP significantly (p < 0.05) raised the SIRT3 protein expression and the downstream functional gene FOXO3a. In the above activity tests, the activity of TSP was slightly higher than that of SBP. Taken together, our findings suggested that SBP and TSP can be used as promising nutrients for oxidative damage reduction in neurons, and TSP is more effective than SBP. Therefore, TSP has the potential to replace SBP and reduce neuronal oxidative damage. Full article
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