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Medicinal Chemistry Advances in Neurodegenerative Disease Therapy

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 2500

Special Issue Editor


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Guest Editor
i3S—Instituto de Investigação e Inovação em Saúde and IBMC—Institute for Molecular and Cell Biology, Porto, Portugal
Interests: vitamin C; antioxidants; neurosciences; antioxidants in neurodegenerative disorders; neuroimmunology; neuroinflammation; microglia; neurotransmitter transporters and receptors

Special Issue Information

Dear Colleagues,

Neurodegenerative disorders have emerged as one of the most severe issues, incurring high financial and moral costs in many nations with the aging of the world population. In the last few decades, little progress has been made in the field of neurology, and most treatments for neurodegenerative disorders are symptomatic rather than slowing the disease's course. To stop the progression of the disease and restore all damaged activities, it is, therefore, necessary to develop new medications or biological agents with more significant bioactivity and safety profiles through multidisciplinary collaboration.

This Special Issue aims to give a multidisciplinary platform for researchers working in this area to present their cutting-edge approaches to treating neurodegenerative disorders or investigating the underlying mechanisms involved in developing the disease. The development of anti-oxidative compounds using nano-biomaterials, the extraction of anti-inflammatory compounds from human platelet lysate, sensory stimulation to correct emotional phenotypes, and the repair of neuronal function using advanced cell therapy, among other things, are some examples of these strategies. We encourage both original writing and reviews.

Additionally, welcomed are stories showing the creative solutions created to address impairments likely to have neurological roots, such as sleep issues or oropharyngeal dysphagia.

Dr. Camila Cabral Portugal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroimmunology
  • neuroscience
  • neuropharmacology

Published Papers (1 paper)

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Review

29 pages, 1824 KiB  
Review
Neuropsychiatric Systemic Lupus Erythematosus: Molecules Involved in Its Imunopathogenesis, Clinical Features, and Treatment
by Angel A. Justiz-Vaillant, Darren Gopaul, Sachin Soodeen, Rodolfo Arozarena-Fundora, Odette Arozarena Barbosa, Chandrashehkar Unakal, Reinand Thompson, Bijay Pandit, Srikanth Umakanthan and Patrick E. Akpaka
Molecules 2024, 29(4), 747; https://doi.org/10.3390/molecules29040747 - 06 Feb 2024
Cited by 1 | Viewed by 2151
Abstract
Systemic lupus erythematosus (SLE) is an idiopathic chronic autoimmune disease that can affect any organ in the body, including the neurological system. Multiple factors, such as environmental (infections), genetic (many HLA alleles including DR2 and DR3, and genes including C4), and immunological influences [...] Read more.
Systemic lupus erythematosus (SLE) is an idiopathic chronic autoimmune disease that can affect any organ in the body, including the neurological system. Multiple factors, such as environmental (infections), genetic (many HLA alleles including DR2 and DR3, and genes including C4), and immunological influences on self-antigens, such as nuclear antigens, lead to the formation of multiple autoantibodies that cause deleterious damage to bodily tissues and organs. The production of autoantibodies, such as anti-dsDNA, anti-SS(A), anti-SS(B), anti-Smith, and anti-neuronal DNA are characteristic features of this disease. This autoimmune disease results from a failure of the mechanisms responsible for maintaining self-tolerance in T cells, B cells, or both. Immune complexes, circulating antibodies, cytokines, and autoreactive T lymphocytes are responsible for tissue injury in this autoimmune disease. The diagnosis of SLE is a rheumatological challenge despite the availability of clinical criteria. NPSLE was previously referred to as lupus cerebritis or lupus sclerosis. However, these terms are no longer recommended because there is no definitive pathological cause for the neuropsychiatric manifestations of SLE. Currently, the treatment options are primarily based on symptomatic presentations. These include the use of antipsychotics, antidepressants, and anxiolytic medications for the treatment of psychiatric and mood disorders. Antiepileptic drugs to treat seizures, and immunosuppressants (e.g., corticosteroids, azathioprine, and mycophenolate mofetil), are directed against inflammatory responses along with non-pharmacological interventions. Full article
(This article belongs to the Special Issue Medicinal Chemistry Advances in Neurodegenerative Disease Therapy)
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