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Molecules
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Chelating Agents towards Bioavailable Metal Ions
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Chelating Agents towards Bioavailable Metal Ions

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 18840

Special Issue Editors

Dr. Emilia Furia

E-Mail Website
Guest Editor
Department of Chemistry and Chemical Technologies, University of Calabria, Rende, Italy
Interests: thermodynamic study of chemical equilibrium; composition of the species formed by bioavailable metal cations and one or more ligands; stability constants under phisiological conditions; sequestering ability of natural ligands towards metals responsible for neurodegenerative diseases
Prof. Dr. Tiziana Marino

E-Mail Website
Co-Guest Editor
Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, 87036 Arcavacata di Rende, CS, Italy
Interests: computational theoretical chemistry; conformational macromolecules; amino acids; peptides; nucleic acid; enzymes; metallo-enzymes; photosensitizer molecules
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal speciation is important since it can be considered as a prerequisite for obtaining structural information and can determine many molecular properties, including adsorption, transport, and related biological activities. Some diseases can be caused by an imbalance between essential and nonessential trace elements. Currently, the direct administration of essential metals and removal of excess of toxic metals via chelation represent good strategies for restoring the normal healthy physiology of the human body for some pathologies. This Special Issue aims to present studies on the complexation behavior of biological ligands towards bioavailable metal ions.

Dr. Emilia Furia
Prof. Tiziana Marino
Guest Editors

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Keywords

  • natural ligands
  • metal ions
  • complexation behavior
  • speciation profile
  • coordination sites
  • sequestering ability

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Published Papers (5 papers)

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Research

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19 pages, 3470 KiB  
Article
Synthesis of Water-Soluble Copolymers of N-vinylpyrrolidone with N-vinyldithiocarbamate as Multidentate Polymeric Chelation Systems and Their Complexes with Indium and Gallium
by Nikolay I. Gorshkov, Andrey Yu. Murko, Irina I. Gavrilova, Marina A. Bezrukova, Albert I. Kipper, Valerii D. Krasikov and Evgenii F. Panarin
Molecules 2020, 25(20), 4681; https://doi.org/10.3390/molecules25204681 - 14 Oct 2020
Cited by 4 | Viewed by 2424
Abstract
Dithiocarbamate (DTC) derivatives of N-vinylpyrrolidone-N-vinylamine (VP–VA) copolymers were synthesized via reaction between the copolymers and carbon disulfide in alkaline medium; molecular masses of the products were 12 and 29 kDa; the VP:VDTC ratios were 94:6 and 83:17 mol.%. Complexation between [...] Read more.
Dithiocarbamate (DTC) derivatives of N-vinylpyrrolidone-N-vinylamine (VP–VA) copolymers were synthesized via reaction between the copolymers and carbon disulfide in alkaline medium; molecular masses of the products were 12 and 29 kDa; the VP:VDTC ratios were 94:6 and 83:17 mol.%. Complexation between the obtained DTC derivatives and metal ions (indium and gallium) was investigated. It was demonstrated that metal–DTC ligand complexes with 1:3 ratio between components were formed. Gallium metal–polymer complexes (MPC) were unstable in solution. Individual indium MPC were isolated and characterized by spectral and chromatographic methods. Unlike similar gallium MPC, they appeared to be stable in histidine challenge reaction. Full article
(This article belongs to the Special Issue Chelating Agents towards Bioavailable Metal Ions)
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16 pages, 2369 KiB  
Article
Interaction of Ampicillin and Amoxicillin with Mn2+: A Speciation Study in Aqueous Solution
by Claudia Foti and Ottavia Giuffrè
Molecules 2020, 25(14), 3110; https://doi.org/10.3390/molecules25143110 - 8 Jul 2020
Cited by 17 | Viewed by 4268
Abstract
A potentiometric and UV spectrophotometric investigation on Mn2+-ampicillin and Mn2+-amoxicillin systems in NaCl aqueous solution is reported. The potentiometric measurements were carried out under different conditions of temperature (15 ≤ t/°C ≤ 37). The obtained speciation pattern includes [...] Read more.
A potentiometric and UV spectrophotometric investigation on Mn2+-ampicillin and Mn2+-amoxicillin systems in NaCl aqueous solution is reported. The potentiometric measurements were carried out under different conditions of temperature (15 ≤ t/°C ≤ 37). The obtained speciation pattern includes two species for both the investigated systems. More in detail, for system containing ampicillin MLH and ML species, for that containing amoxicillin, MLH2 and MLH ones. The spectrophotometric findings have fully confirmed the results obtained by potentiometry for both the systems, in terms of speciation models as well as the stability constants of the formed species. Enthalpy change values were calculated via the dependence of formation constants of the species on temperature. The sequestering ability of ampicillin and amoxicillin towards Mn2+ was also evaluated under different conditions of pH and temperature via pL0.5 empirical parameter (i.e., cologarithm of the ligand concentration required to sequester 50% of the metal ion present in traces). Full article
(This article belongs to the Special Issue Chelating Agents towards Bioavailable Metal Ions)
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15 pages, 11364 KiB  
Article
A New Tetradentate Mixed Aza-Thioether Macrocycle and Its Complexation Behavior towards Fe(II), Ni(II) and Cu(II) Ions
by Sze-Wing Ng, Siu-Chung Chan, Chi-Fung Yeung, Shek-Man Yiu and Chun-Yuen Wong
Molecules 2020, 25(9), 2030; https://doi.org/10.3390/molecules25092030 - 27 Apr 2020
Cited by 2 | Viewed by 3541
Abstract
A new tetradentate mixed aza-thioether macrocyclic ligand 2,6-dithia[7](2,9)-1,10-phenanthrolinophane ([13]ane(phenN2)S2) was successfully synthesized. Reacting metal precursors [Fe(CH3CN)2(OTf)2], Ni(ClO4)2·6H2O, and Cu(ClO4)2·6H2O with one [...] Read more.
A new tetradentate mixed aza-thioether macrocyclic ligand 2,6-dithia[7](2,9)-1,10-phenanthrolinophane ([13]ane(phenN2)S2) was successfully synthesized. Reacting metal precursors [Fe(CH3CN)2(OTf)2], Ni(ClO4)2·6H2O, and Cu(ClO4)2·6H2O with one equivalent of [13]ane(phenN2)S2 afforded [Fe([13]ane(phenN2)S2)(OTf)2] (1), [Ni([13]ane(phenN2)S2)](ClO4)2 (2(ClO4)2), and [Cu([13]ane(phenN2)S2)(OH2)](ClO4)2 (3(ClO4)2), respectively. The structures of [13]ane(phenN2)S2 and all of its metal complexes were investigated by X-ray crystallography. The [13]ane(phenN2)S2 was found to behave as a tetradentate ligand via its donor atoms N and S. Full article
(This article belongs to the Special Issue Chelating Agents towards Bioavailable Metal Ions)
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15 pages, 2866 KiB  
Article
Estimation of the Chelating Ability of an Extract from Aronia melanocarpa L. Berries and Its Main Polyphenolic Ingredients Towards Ions of Zinc and Copper
by Sylwia Borowska, Michał Tomczyk, Jakub W. Strawa and Małgorzata M. Brzóska
Molecules 2020, 25(7), 1507; https://doi.org/10.3390/molecules25071507 - 26 Mar 2020
Cited by 15 | Viewed by 4193
Abstract
Previously, we have revealed that prolonged administration of a polyphenol-rich 0.1% extract from the berries of Aronia melanocarpa L. (chokeberries) alone and under chronic exposure to cadmium influences the body status of zinc (Zn) and copper (Cu). The aim of this study was [...] Read more.
Previously, we have revealed that prolonged administration of a polyphenol-rich 0.1% extract from the berries of Aronia melanocarpa L. (chokeberries) alone and under chronic exposure to cadmium influences the body status of zinc (Zn) and copper (Cu). The aim of this study was to evaluate, in an in vitro model, the chelating properties of the extract (0.05% and 0.1%) and its main polyphenolic ingredients (cyanidin 3-O-β-galactoside, chlorogenic acid, neochlorogenic acid, (+)-catechin, (−)-epicatechin, quercetin, and kaempferol) regarding divalent ions of Zn (Zn2+) and Cu (Cu2+) at pH reflecting physiological conditions at the gastrointestinal tract such as 2 (empty stomach), 5.5 (full stomach), and 8 (duodenum). The study has revealed that the extract from Aronia berries, as well as cyanidin 3-O-β-galactoside and quercetin, can bind Zn2+ and Cu2+, but only at pH 5.5. Moreover, kaempferol was able to chelate Zn2+ at pH 5.5; however, this ability was weaker than those of cyanidin 3-O-β-galactoside and quercetin. The ability of the chokeberry extract to chelate Zn2+ and Cu2+ may be explained, at least partially, by the presence of polyphenols such as anthocyanin derivatives of cyanidin and quercetin. The findings seem to suggest that Aronia products, used as supplements of a diet, should be consumed before meals, and particular attention should be paid to adequate intake of Zn and Cu under prolonged consumption of these products to avoid deficiency of both bioelements in the body due to their complexation by chokeberry ingredients in the lumen of the gastrointestinal tract. Full article
(This article belongs to the Special Issue Chelating Agents towards Bioavailable Metal Ions)
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Review

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24 pages, 2930 KiB  
Review
A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights
by Luana Malacaria, Giuseppina Anna Corrente, Amerigo Beneduci, Emilia Furia, Tiziana Marino and Gloria Mazzone
Molecules 2021, 26(9), 2603; https://doi.org/10.3390/molecules26092603 - 29 Apr 2021
Cited by 31 | Viewed by 3638
Abstract
This review focuses on the ability of some natural antioxidant molecules (i.e., hydroxycinnamic acids, coumarin-3-carboxylic acid, quercetin, luteolin and curcumin) to form Al(III)- and Fe(III)-complexes with the aim of evaluating the coordination properties from a combined experimental and theoretical point of view. Despite [...] Read more.
This review focuses on the ability of some natural antioxidant molecules (i.e., hydroxycinnamic acids, coumarin-3-carboxylic acid, quercetin, luteolin and curcumin) to form Al(III)- and Fe(III)-complexes with the aim of evaluating the coordination properties from a combined experimental and theoretical point of view. Despite the contributions of previous studies on the chemical properties and biological activity of these metal complexes involving such natural antioxidants, further detailed relationships between the structure and properties are still required. In this context, the investigation on the coordination properties of Al(III) and Fe(III) toward these natural antioxidant molecules might deserve high interest to design water soluble molecule-based metal carriers that can improve the metal’s intake and/or its removal in living organisms. Full article
(This article belongs to the Special Issue Chelating Agents towards Bioavailable Metal Ions)
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