The Click Reaction: A Powerful and Widely Used Tool in Drug Discovery, Bioconjugation, and Materials Science

Dear Colleagues,

“Click” chemistry is a chemical philosophy introduced by Sharpless, Finn and Fokin in early 21st century and describes a methodology of neat tailoring of substances by joining small units together. “Click” chemistry has made an extensive contribution to many areas of modern chemistry from small molecule synthesis to drug discovery to materials science. Reactions united by the “click” family have a strong energy driving force that ensures starting compounds to react promptly, efficiently, and with no undesired byproducts even under physiological conditions, which make these transformations perfect models of biorthogonality. Examples of “click”-reactions include Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) Reaction, Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC) Reaction, Strain-Promoted Alkyne-Nitrone Cycloaddition (SPANC) Reaction, Alkene and Tetrazine Inverse-Demand Diels-Alder Reaction, Alkene and Tetrazole Photoclick Reaction, Thiol–ene “click” reaction, Sulfur Fluorine Exchange (SuFEx) reaction etc.

Research papers, as well as reviews, will be considered for publication. This Special issue aims to focus on the applications of click chemistry in drug discovery, bioconjugation, and materials science. Resent advancement in methodology and mechanistic studies in the field of “click”-chemistry will be also covered in the Special issue.

Dr. Joice Thomas
Dr. Nithya Joseph
Dr. Dmitry Eremin
Guest Editors

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