New Therapeutic Tools against MDR Tumors: Discovery, Synthesis and Evaluation of Bioactive Compounds

Dear Colleagues,

Multidrug resistance (MDR) is one of the major obstacles to clinical treatment, resulting from different defensive mechanisms in cancer. To circumvent MDR many reversal agents have been developed, from a broad collaboration between synthetic/ medicinal chemists and biologists. At present, a plethora of synthetic strategies helps researchers in building molecular libraries, often having templates directly inspired by nature. As a consequence, the development of new methods that can be applied in preparing new and powerful bioactive compounds is a fundamental need for the treatment of MDR tumors.

In this Special Issue, we wish to focus on the most recent research efforts, toward the discovery of lead compounds and the development of drug candidates for successful therapies against MDR tumors. Special attention will be given to interdisciplinary studies on novel therapeutic agents targeting specific receptors, enzymes, or cellular pathways related to MDR.

Original research articles, reviews, and focus papers will be welcome, with the aim of collecting the most recent insights and results on new and straightforward synthetic approaches to bioactive organic compounds, the preparation of molecular templates for combinatorial chemistry, as well as the application of computational methods for the rational design and synthesis of novel lead drug candidates, focusing on fighting MDR tumors.

Prof. Dr. Constantinos Athanassopoulos
Dr. Antonia Antoniou
Guest Editors

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