Protein Kinases and Their Inhibitors
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 3735
Special Issue Editors
Interests: medicinal chemistry; autophagy; epigenetics; protein kinase inhibitors; breast cancer; Parkinson’s disease; drug repurposing
Interests: medicinal chemistry; autophagy; neurodegenerative disease; cancer; drug repurposing
Special Issue Information
Dear Colleagues,
Protein kinases (PKs) catalyze the transfer of the γ‑phosphate group of ATP onto a target substrate. A sequence of such phosphorylation events regulates numerous cellular activities, such as proliferation, survival, apoptosis, metabolism, transcription and differentiation. Owing to overexpression and genetic alterations such as mutations and translocations, the dysregulation of protein kinase activity is involved in the pathogenesis of many diseases including autoimmune, cardiovascular, neurodegenerative and inflammatory diseases, as well as a number of malignancies. Accordingly, protein kinases have become one of the most important drug targets over the past two decades. Although substantial progress has been made in the development and discovery of small-molecule protein kinase inhibitors since the FDA approval of imatinib in 2001, this field remains in its early stages. Therefore, we believe that the discovery and optimization of novel small-molecule protein kinase inhibitors will provide more information and experience to related researchers from both the pharmaceutical field and academia.
In this context, it is a great pleasure to invite you to contribute to this thematic Special Issue of Molecules entitled “Protein Kinases and Their Inhibitors”, which will cover the latest research trends and applications in the field. Submissions of reviews and original research papers are highly welcome. Topics of interest include, but are not limited to, the following:
- Design and discovery of novel small-molecule protein kinase inhibitors for disease treatment;
- Drug repositioning of protein kinase inhibitors.
Dr. Lan Zhang
Dr. Guan Wang
Dr. Dahong Yao
Guest Editors
Manuscript Submission Information
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Keywords
- protein kinase
- inhibitors
- activators
- drug design
- drug discovery
- structure optimization
- drug repositioning
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