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Molecules
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Applications of Liquid Chromatography or Mass Spectrometry
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Applications of Liquid Chromatography or Mass Spectrometry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3022

Special Issue Editors

Dr. Lei Yin

E-Mail Website
Guest Editor
School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, China
Interests: pharmaceutical analysis; analytical chemistry; pharmacokinetics; traditional Chinese medicine; drug metabolism; LC-MS/MS
Dr. Zhonghua Wang

E-Mail Website
Guest Editor
Key Laboratory of Mass Spectrometry Imaging and Metabolomics, Minzu University of China, Beijing, China
Interests: mass spectrometry imaging and metabolomics
Special Issues, Collections and Topics in MDPI journals
Dr. Heyun Zhu

E-Mail Website
Guest Editor
School of Pharmacy, Jilin Medical University, Jilin 132013, China
Interests: pharmaceutical analysis; analytical chemistry; pharmacokinetics; traditional Chinese medicine; drug metabolism; LC-MS/MS

Special Issue Information

Dear Colleagues,

Pharmaceutical analysis is an important branch of analytical chemistry. With the development of pharmaceutical chemistry, it has gradually become a relatively independent discipline in analytical chemistry, and has been widely used in drug quality control, new drug research, drug metabolism, chiral drug analysis, etc. Liquid chromatography and mass spectrometry techniques are widely used in pharmaceutical analysis due to their good separation, high sensitivity and high selectivity.

The aim of this Special Issue is to gather original research and review articles focusing on the applications of liquid chromatography or mass spectrometry and other techniques for the qualitative and quantitative analysis of small moleculs or large molecules. Other techniques used in pharmaceutical analysis are also welcomed.

We look forward to receiving your contributions.

Dr. Lei Yin
Dr. Zhonghua Wang
Dr. Heyun Zhu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPLC
  • LC-MS/MS
  • mass spectrometry imaging
  • pharmacokinetics

Published Papers (2 papers)

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Research

12 pages, 4101 KiB  
Article
Differential Mobility Spectrometry-Tandem Mass Spectrometry with Multiple Ion Monitoring Coupled with in Source-Collision Induced Dissociation: A New Strategy for the Quantitative Analysis of Pharmaceutical Polymer Excipients in Rat Plasma
by Yuyao Zhang, Zhi Zhang, Yingze Liu, Deqi Cai, Jingkai Gu and Dong Sun
Molecules 2023, 28(12), 4782; https://doi.org/10.3390/molecules28124782 - 15 Jun 2023
Cited by 1 | Viewed by 1099
Abstract
Polylactic acids (PLAs) are synthetic polymers composed of repeating lactic acid subunits. For their good biocompatibility, PLAs have been approved and widely applied as pharmaceutical excipients and scaffold materials. Liquid chromatography-tandem mass spectrometry is a powerful analytical tool not only for pharmaceutical ingredients [...] Read more.
Polylactic acids (PLAs) are synthetic polymers composed of repeating lactic acid subunits. For their good biocompatibility, PLAs have been approved and widely applied as pharmaceutical excipients and scaffold materials. Liquid chromatography-tandem mass spectrometry is a powerful analytical tool not only for pharmaceutical ingredients but also for pharmaceutical excipients. However, the characterization of PLAs presents particular problems for mass spectrometry techniques. In addition to their high molecular weights and wide polydispersity, multiple charging and various adductions are intrinsic features of electrospray ionization. In the present study, a strategy combining of differential mobility spectrometry (DMS), multiple ion monitoring (MIM) and in-source collision-induced dissociation (in source-CID) has been developed and applied to the characterization and quantitation of PLAs in rat plasma. First, PLAs will be fragmented into characteristic fragment ions under high declustering potential in the ionization source. The specific fragment ions are then screened twice by quadrupoles to ensure a high signal intensity and low interference for mass spectrometry detection. Subsequently, DMS technique has been applied to further reduce the background noise. The appropriately chosen surrogate specific precursor ions could be utilized for the qualitative and quantitative analysis of PLAs, which provided results with the advantages of low endogenous interference, sufficient sensitivity and selectivity for bioassay. The linearity of the method was evaluated over the concentration range 3–100 μg/mL (r2 = 0.996) for PLA 20,000. The LC-DMS-MIM coupled with in source-CID strategy may contribute to the pharmaceutical studies of PLAs and the possible prospects of other pharmaceutical excipients. Full article
(This article belongs to the Special Issue Applications of Liquid Chromatography or Mass Spectrometry)
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11 pages, 2252 KiB  
Article
A High-Performance Liquid Chromatography—Mass Spectrometry Method for Simultaneous Determination of Vancomycin, Meropenem, and Valproate in Patients with Post-Craniotomy Infection
by Yuting Jin, Qiang Sun, Yumei Pei and Jing Huang
Molecules 2023, 28(6), 2439; https://doi.org/10.3390/molecules28062439 - 7 Mar 2023
Cited by 2 | Viewed by 1569
Abstract
Vancomycin (VAN), meropenem (MER), and valproate (VPA) are commonly used to treat intracranial infection post-craniotomy and prevent associated epilepsy. To monitor their levels, we developed a novel bioassay based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) for simultaneous determination of these three drugs in [...] Read more.
Vancomycin (VAN), meropenem (MER), and valproate (VPA) are commonly used to treat intracranial infection post-craniotomy and prevent associated epilepsy. To monitor their levels, we developed a novel bioassay based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) for simultaneous determination of these three drugs in human serum and cerebrospinal fluid (CSF). Sample preparation by protein precipitation using acetonitrile was followed by HPLC on a Zorbax 300SB-C8 column (150 mm × 4.6 mm, 5 μm) maintained at 40 °C. The lower limit of quantification (LLOQ) was 5 ng/mL for MER, 0.1 μg/mL for VAN, and 1 μg/mL for VPA in serum and 50 ng/mL for MER, 1 μg/mL for VAN, and 2 μg/mL for VPA in CSF. This method was validated with satisfactory linearity, sensitivity, precision, accuracy, recovery, matrix effects, and stability for all analytes. The assay was then successfully applied to evaluate VPA, MER, and VAN levels in serum and CSF from patients with intracranial infection administrated by intrathecal injection. Compared with intravenous injections, an intrathecal injection can provide sufficient therapeutic effects even if the CSF levels did not reach the effective concentration reported. Our method provided a detection tool to study the effective concentrations of these three drugs in CSF from patients administered via intrathecal injection. Full article
(This article belongs to the Special Issue Applications of Liquid Chromatography or Mass Spectrometry)
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