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Novel Nanomedicines for Cancer Therapy

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2893

Special Issue Editors

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
Interests: nano-bio interaction; nanozyme; nanocatalytic medicine; tumor radiotherapy
The Department of pharmacy, School of Chemistry and Chemical Engineering,Shanghai University of Engingeering Science, Shanghai 201620 ,China
Interests: biomaterials; nanomedicine; tumor therapy; immunotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer remains a leading cause of mortality worldwide, and has become a major global public health issue. In recent years, rapid progress in novel nanomaterials and nanomedicines has demonstrated great promise in improving the therapeutic outcomes relating to cancer. Nanomedicines can not only be designed as drug delivery systems, but also possess unique physicochemical properties, which can be activated by external excitations such as near-infrared light, X-rays, ultrasound, and magnetic fields, and trigger tumor microenvironment-responsive nanocatalytic reactions in the tumor region to achieve enhanced anti-cancer efficacy.

In this Special Issue, we aim to cover the latest research on multifunctional nanomaterials and novel nanomedicines for cancer therapy. We cordially welcome investigators to submit articles to this Special Issue (original research, review, and perspective articles). Topics will include (but are not limited to):

  • Nano-drug delivery systems for cancer therapy;
  • Functional nanomaterials activated by external excitations such as near-infrared light, X-ray, ultrasound, and magnetic fields;
  • Nanomedicine with tumor microenvironment-responsive nanocatalytic therapy

Dr. Yu Chong
Dr. Yu Luo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials-based drug delivery
  • nanocatalytic medicine
  • immune modulatable nanomedicine
  • nano-radiosensitizer
  • nanozyme
  • tumor microenvironment
  • photodynamic therapy

Published Papers (1 paper)

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Review

20 pages, 4151 KiB  
Review
Nanomaterials with Glucose Oxidase-Mimicking Activity for Biomedical Applications
by Shengyi Min, Qiao Yu, Jiaquan Ye, Pengfei Hao, Jiayu Ning, Zhiqiang Hu and Yu Chong
Molecules 2023, 28(12), 4615; https://doi.org/10.3390/molecules28124615 - 7 Jun 2023
Cited by 2 | Viewed by 2621
Abstract
Glucose oxidase (GOD) is an oxidoreductase that catalyzes the aerobic oxidation of glucose into hydrogen peroxide (H2O2) and gluconic acid, which has been widely used in industrial raw materials production, biosensors and cancer treatment. However, natural GOD bears intrinsic [...] Read more.
Glucose oxidase (GOD) is an oxidoreductase that catalyzes the aerobic oxidation of glucose into hydrogen peroxide (H2O2) and gluconic acid, which has been widely used in industrial raw materials production, biosensors and cancer treatment. However, natural GOD bears intrinsic disadvantages, such as poor stability and a complex purification process, which undoubtedly restricts its biomedical applications. Fortunately, several artificial nanomaterials have been recently discovered with a GOD-like activity and their catalytic efficiency toward glucose oxidation can be finely optimized for diverse biomedical applications in biosensing and disease treatments. In view of the notable progress of GOD-mimicking nanozymes, this review systematically summarizes the representative GOD-mimicking nanomaterials for the first time and depicts their proposed catalytic mechanisms. We then introduce the efficient modulation strategy to improve the catalytic activity of existing GOD-mimicking nanomaterials. Finally, the potential biomedical applications in glucose detection, DNA bioanalysis and cancer treatment are highlighted. We believe that the development of nanomaterials with a GOD-like activity will expand the application range of GOD-based systems and lead to new opportunities of GOD-mimicking nanomaterials for various biomedical applications. Full article
(This article belongs to the Special Issue Novel Nanomedicines for Cancer Therapy)
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