Molecular Biophysics of Viral Proteins

Dear Colleagues,

Viral proteins play essential roles in the infectivity, replication, and immune evasion strategies of viruses, making them key targets for therapeutic intervention. Understanding the molecular biophysics behind these proteins—how their structure, dynamics, and interactions dictate viral behavior—is fundamental for advancing antiviral drug design, vaccine development, and diagnostic tools.

This Special Issue invites cutting-edge research and comprehensive reviews that explore the physical principles governing the function, interactions, and assembly of viral proteins. Topics may include (but are not limited to) the following: structural characterization; protein folding and stability; protein–ligand interaction; membrane association; host–virus interactions; and computational modeling. We also encourage interdisciplinary contributions that integrate biophysics with fields such as virology, molecular biology, immunology, nanotechnology, and medicinal chemistry.

Articles exploring innovative methodologies, such as cryo-EM, spectroscopy, molecular dynamics simulations, and single-molecule techniques, are especially welcome. By uniting diverse perspectives, this Special Issue aims to deepen our understanding of viral protein machinery and inspire new strategies for combating viral diseases.

We look forward to receiving your contributions.

Dr. Ícaro Putinhon Caruso
Guest Editor

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