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Advances in Fluorescent Probes

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 1792

Special Issue Editors


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Guest Editor
Department of Chemistry, Nanchang University, Nanchang 330031, China
Interests: nanoenzyme; fluorescent probes; chemical sensors; pesticide; uric acid

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Guest Editor
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China
Interests: fluorescent probes; colorimetry; metal nanoclusters and nanoparticles; metal–organic framework; carbon dots; cell imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fluorescent probes are a newly developed class of analytical tool that offer the benefits of high sensitivity, good selectivity, low toxicity, and noninvasive real-time visual monitoring. There has been exceptional progress in the development and application of fluorescent probes over the past few decades. They are now frequently employed for drug discovery, cell imaging, environmental monitoring, food safety, and medical applications, and have gradually occupied an indispensable position.

Despite many beneficial advances, remaining challenges include precise synthesis, tunable fluorescence, as well as specificity, sensitivity, security and spatiotemporal resolution of fluorescent probes especially for imaging studies. This Special Issue's goal is to compile the most recent developments in fluorescence probe research. Unique synthesis techniques, fresh fluorescent probe materials, novel luminescence and response mechanisms, and their uses in advanced sectors are just a few of the themes that are pertinent.

We sincerely welcome you to submit your research on all relevant topics for this Special Issue in the form of full papers, reviews or communications.

Prof. Dr. Ping Qiu
Dr. Pengcheng Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescent probes
  • precise synthesis
  • tunable fluorescence
  • response mechanisms
  • drug discovery
  • cell imaging
  • environmental monitoring
  • food analysis
  • pharmacological research
  • clinical treatment
  • target tracking

Published Papers (1 paper)

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Research

14 pages, 7199 KiB  
Article
A Study of the Mechanisms and Characteristics of Fluorescence Enhancement for the Detection of Formononetin and Ononin
by Jinjin Cao, Tingting Li, Ting Liu, Yanhui Zheng, Jiamiao Liu, Qifan Yang, Xuguang Li, Wenbo Lu, Yongju Wei and Wenhong Li
Molecules 2023, 28(4), 1543; https://doi.org/10.3390/molecules28041543 - 5 Feb 2023
Cited by 1 | Viewed by 1493
Abstract
In this work, the origins for the spectral difference between two isoflavones, formononetin (F) and ononin (FG), are revealed via a comparison study of the fluorescence molecular structure. The fluorescence enhancement of FG in hot alkaline conditions is reported for the first time. [...] Read more.
In this work, the origins for the spectral difference between two isoflavones, formononetin (F) and ononin (FG), are revealed via a comparison study of the fluorescence molecular structure. The fluorescence enhancement of FG in hot alkaline conditions is reported for the first time. For F, there is almost no fluorescence under acidic conditions, but when the pH is >4.8, its fluorescence begins to increase due to the deprotonation of 7-OH. Under a pH between 9.3 and 12.0, the anionic form of F produces a strong and stable fluorescence. The fluorescence quantum yield (Yf) of F is measured to be 0.042. FG shows only weak fluorescence in aqueous solutions under a wide range of pH until it is placed in hot alkaline solutions, which is attributed to the cleavage reaction of the γ-pyrone ring in FG. The Yf of FG is determined to be 0.020. Based on the fluorescence sensitization methods of F and FG, the quantitative analysis and detection of two substances can be realized. The limit of the detections for F and FG are 2.60 ng·mL−1 and 9.30 ng·mL−1, respectively. The linear detection ranges of F and FG are 11.7~1860 ng·mL−1 and 14.6~2920 ng·mL−1, respectively. Although the structural relationship between F and FG is glycoside and aglycone, under hot alkaline conditions, the final products after the cleavage and hydrolysis reactions are essentially different. The different fluorescence characteristics between F and FG pave a way for further identification and a quantitative analysis of the corresponding components in Chinese herbal medicine. Full article
(This article belongs to the Special Issue Advances in Fluorescent Probes)
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