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Molecules
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Marine Microbial Metabolites: Discovery, Synthesis, and Biosynthesis
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Marine Microbial Metabolites: Discovery, Synthesis, and Biosynthesis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 7709

Special Issue Editor

Prof. Dr. Yonghong Liu

E-Mail Website
Guest Editor
1. Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi, China
2. Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
Interests: marine organisms bioactive metabolites; marine natural products; marine drugs; marine microorganism; marine fungi; secondary metabolites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The ocean is the source of life and the habitat of 80% of species on Earth. The particularity of the marine ecological environment has resulted in rich biological and unique chemical diversity; as a result, secondary metabolites have complex and unique structures and specific and efficient activities. Marine natural products have the characteristics of novel structure, high activity, and high druggability and are important resources for new drug research and development in the pharmaceutical industry. Marine microorganisms are the most dominant and characteristic marine living resources. Research on marine microbial active substances is the basis of innovative drugs, and also the starting point of chemical and biological synthesis of active substances. Marine microorganisms can be industrialized through large-scale fermentation. Chemical synthesis and biosynthetic technology will provide a new way for the rapid development of the marine microbial industry. It is an important breakthrough to solve the bottleneck of marine drug sources.

Prof. Dr. Yonghong Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine microbial metabolites
  • Marine microbial natural product discovery
  • Marine microbial natural product synthesis
  • Marine microbial natural product biosynthesis

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Published Papers (2 papers)

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Research

10 pages, 1959 KiB  
Article
Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202
by Surun Shao, Xueni Wang, Jianglian She, Han Zhang, Xiaoyan Pang, Xiuping Lin, Xuefeng Zhou, Yonghong Liu, Yunqiu Li and Bin Yang
Molecules 2022, 27(6), 1823; https://doi.org/10.3390/molecules27061823 - 11 Mar 2022
Cited by 3 | Viewed by 2032
Abstract
Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis [...] Read more.
Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC50 value of 1.31 μM, and 5 showed significant cytotoxicity against PC-3 cells, with an IC50 value of 2.32 μM. Full article
(This article belongs to the Special Issue Marine Microbial Metabolites: Discovery, Synthesis, and Biosynthesis)
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10 pages, 2672 KiB  
Article
Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407
by Jian Cai, Chunmei Chen, Yanhui Tan, Weihao Chen, Xiaowei Luo, Lianxiang Luo, Bin Yang, Yonghong Liu and Xuefeng Zhou
Molecules 2021, 26(16), 4851; https://doi.org/10.3390/molecules26164851 - 11 Aug 2021
Cited by 14 | Viewed by 4814
Abstract
Ten polyketide derivatives (1–10), including a new natural product named (E)-2,4-dihydroxy-3-methyl-6-(2-oxopent-3-en-1-yl) benzaldehyde (1), and five known diketopiperazines (11–15), were isolated from the mangrove-sediment-derived fungus Aspergillus sp. SCSIO41407. The structures of 1 [...] Read more.
Ten polyketide derivatives (1–10), including a new natural product named (E)-2,4-dihydroxy-3-methyl-6-(2-oxopent-3-en-1-yl) benzaldehyde (1), and five known diketopiperazines (11–15), were isolated from the mangrove-sediment-derived fungus Aspergillus sp. SCSIO41407. The structures of 1–15 were determined via NMR and MS spectroscopic analysis. In a variety of bioactivity screening, 3 showed weak cytotoxicity against the A549 cell line, and 2 exhibited weak antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 3, 5, and 6 showed inhibition against acetylcholinesterase (AChE) with IC50 values of 23.9, 39.9, and 18.6 μM. Compounds 11, 12, and 14 exhibited obvious inhibitory activities of lipopolysaccharide (LPS)-induced nuclear factor-κB (NF-κB) with IC50 values of 19.2, 20.9, and 8.7 μM, and they also suppressed RANKL-induced osteoclast differentiation in bone marrow macrophages cells (BMMCs), with the concentration of 5 μM. In silico molecular docking with AChE and NF-κB p65 protein were also performed to understand the inhibitory activities, and 1, 11–14 showed obvious protein/ligand-binding effects to the NF-κB p65 protein. Full article
(This article belongs to the Special Issue Marine Microbial Metabolites: Discovery, Synthesis, and Biosynthesis)
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