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Molecules
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Photothermal Therapy: Efficiency and Future Directions
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Photothermal Therapy: Efficiency and Future Directions

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4565

Special Issue Editor

Prof. Dr. Jin Zhou

E-Mail Website
Guest Editor
College of Pharmacy, Weifang Medical University, Weifang, China
Interests: fluorescent probe; phototherapy; drug delivery system; bioimaging; tumor diagnosis

Special Issue Information

Dear Colleagues,

Light-activated, photosensitizer-based therapies have been established as safe modalities for the treatment of various diseases, such as Alzheimer’s disease, dermatological disease and tumor ablation for numerous indications. Photothermal therapy, which results in localized thermal damage, is one of the main approaches available. There are still many challenges to enhance the efficiency and efficacy of this treatment approach.

It is our great pleasure to invite you to submit a paper to Molecules.

Prof. Dr. Jin Zhou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photothermal therapy
  • clinical development
  • nanophotosensitizer complexes
  • multifunctional diagnostic and therapeutic agents
  • future directions

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Published Papers (2 papers)

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Research

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16 pages, 7889 KiB  
Article
Cold Atmospheric Plasma Activates Selective Photothermal Therapy of Cancer
by Jiamin Qin, Jingqi Zhang, Guojuan Fan, Xiaoxia Wang, Yuzhong Zhang, Ling Wang, Yapei Zhang, Qingfa Guo, Jin Zhou, Weifen Zhang and Jinlong Ma
Molecules 2022, 27(18), 5941; https://doi.org/10.3390/molecules27185941 - 13 Sep 2022
Cited by 4 | Viewed by 1834
Abstract
Due to the body’s systemic distribution of photothermal agents (PTAs), and to the imprecise exposure of lasers, photothermal therapy (PTT) is challenging to use in treating tumor sites selectively. Striving for PTT with high selectivity and precise treatment is nevertheless important, in order [...] Read more.
Due to the body’s systemic distribution of photothermal agents (PTAs), and to the imprecise exposure of lasers, photothermal therapy (PTT) is challenging to use in treating tumor sites selectively. Striving for PTT with high selectivity and precise treatment is nevertheless important, in order to raise the survival rate of cancer patients and lower the likelihood of adverse effects on other body sections. Here, we studied cold atmospheric plasma (CAP) as a supplementary procedure to enhance selectivity of PTT for cancer, using the classical photothermic agent’s gold nanostars (AuNSs). In in vitro experiments, CAP decreases the effective power of PTT: the combination of PTT with CAP at lower power has similar cytotoxicity to that using higher power irradiation alone. In in vivo experiments, combination therapy can achieve rapid tumor suppression in the early stages of treatment and reduce side effects to surrounding normal tissues, compared to applying PTT alone. This research provides a strategy for the use of selective PTT for cancer, and promotes the clinical transformation of CAP. Full article
(This article belongs to the Special Issue Photothermal Therapy: Efficiency and Future Directions)
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Review

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14 pages, 2643 KiB  
Review
Nanostructures as Photothermal Agents in Tumor Treatment
by Yuqian Chen, Futing Zhou, Chenshuai Wang, Linlin Hu and Pengfei Guo
Molecules 2023, 28(1), 277; https://doi.org/10.3390/molecules28010277 - 29 Dec 2022
Cited by 13 | Viewed by 2387
Abstract
Traditional methods of tumor treatment such as surgical resection, chemotherapy, and radiation therapy have certain limitations, and their treatment effects are not always satisfactory. As a new tumor treatment method, photothermal therapy based on nanostructures has attracted the attention of researchers due to [...] Read more.
Traditional methods of tumor treatment such as surgical resection, chemotherapy, and radiation therapy have certain limitations, and their treatment effects are not always satisfactory. As a new tumor treatment method, photothermal therapy based on nanostructures has attracted the attention of researchers due to its characteristics of minimally invasive, low side effects, and inhibition of cancer metastasis. In recent years, there has been a variety of inorganic or organic nanostructures used in the field of photothermal tumor treatment, and they have shown great application prospects. In this paper, the advantages and disadvantages of a variety of nanomaterials/nanostructures as photothermal agents (PTAs) for photothermal therapy as well as their research progress are reviewed. For the sake of clarity, the recently reported nanomaterials/nanostructures for photothermal therapy of tumor are classified into five main categories, i.e., carbon nanostructures, noble metal nanostructures, transition metal sulfides, organic polymer, and other nanostructures. In addition, future perspectives or challenges in the related field are discussed. Full article
(This article belongs to the Special Issue Photothermal Therapy: Efficiency and Future Directions)
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