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Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Health and Medicine
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Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Health and Medicine

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3172

Special Issue Editor

Dr. Stefano Fornasaro

E-Mail Website
Guest Editor
Raman Spectroscopy Lab, Department of Engineering and Architecture, University of Trieste, 34100 Trieste, Italy
Interests: chemometrics; SERS; vibrational spectroscopy; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Surface-enhanced Raman scattering (SERS) spectroscopy has led to remarkable achievements in the field of bio- and chemical sensing, including applications in therapeutic drug monitoring, antimicrobial susceptibility testing and pathogen identification, point-of-care diagnostics, single-cell analysis, liquid biopsy, and theranostics.

SERS combines molecular information with the plasmonic properties of metallic nanostructures, offering high specificity, sensitivity, and improved speed to reaching results. The versatility of this technique arises from the ability to use different sensing schemes, loosely classified as direct (label-free) and indirect SERS approaches, which can be tailored to tackle specific challenging requirements. For label-free approaches, subsequent use of advanced chemometrics and machine learning algorithms is required to better understand the results obtained using SERS.

In this Special Issue, we invite researchers from interdisciplinary fields to submit original articles and review practical applications of SERS spectroscopy to health and medicine.

Dr. Stefano Fornasaro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SERS
  • AST
  • point of care
  • diagnostics
  • TDM
  • liquid biopsy
  • chemometrics
  • pathogen identification
  • vibrational spectroscopy

Published Papers (2 papers)

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Research

13 pages, 6398 KiB  
Article
SERS Detection of the Anti-Epileptic Drug Perampanel in Human Saliva
by Matteo Tommasini, Andrea Lucotti, Luca Stefani, Sebastiano Trusso and Paolo M. Ossi
Molecules 2023, 28(11), 4309; https://doi.org/10.3390/molecules28114309 - 24 May 2023
Cited by 1 | Viewed by 1413
Abstract
Surface-Enhanced Raman Scattering (SERS) can obtain the spectroscopic response of specific analytes. In controlled conditions, it is a powerful quantitative technique. However, often the sample and its SERS spectrum are complex. Pharmaceutical compounds in human biofluids with strong interfering signals from proteins and [...] Read more.
Surface-Enhanced Raman Scattering (SERS) can obtain the spectroscopic response of specific analytes. In controlled conditions, it is a powerful quantitative technique. However, often the sample and its SERS spectrum are complex. Pharmaceutical compounds in human biofluids with strong interfering signals from proteins and other biomolecules are a typical example. Among the techniques for drug dosage, SERS was reported to detect low drug concentrations, with analytical capability comparable to that of the assessed High-Performance Liquid Chromatography. Here, for the first time, we report the use of SERS for Therapeutic Drug Monitoring of the Anti-Epileptic Drug Perampanel (PER) in human saliva. We used inert substrates decorated with gold NPs deposited via Pulsed Laser Deposition as SERS sensors. We show that it is possible to detect PER in saliva via SERS after an optimized treatment of the saliva sample. Using a phase separation process, it is possible to extract all the diluted PER in saliva from the saliva phase to a chloroform phase. This allows us to detect PER in the saliva at initial concentrations of the order of 10−7 M, thus approaching those of clinical interest. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Health and Medicine)
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12 pages, 5541 KiB  
Article
Application of Cotton Swab–Ag Composite as Flexible Surface-Enhanced Raman Scattering Substrate for DMMP Detection
by Wen-Chien Huang and Hong-Ru Chen
Molecules 2023, 28(2), 520; https://doi.org/10.3390/molecules28020520 - 5 Jan 2023
Cited by 2 | Viewed by 1434
Abstract
It is both important and required to quickly and accurately detect chemical warfare agents, such as the highly toxic nerve agent sarin. Surface-enhanced Raman scattering (SERS) has received considerable attention due to its rapid results, high sensitivity, non-destructive data acquisition, and unique spectroscopic [...] Read more.
It is both important and required to quickly and accurately detect chemical warfare agents, such as the highly toxic nerve agent sarin. Surface-enhanced Raman scattering (SERS) has received considerable attention due to its rapid results, high sensitivity, non-destructive data acquisition, and unique spectroscopic fingerprint. In this work, we successfully prepared SERS cotton swabs (CSs) for the detection of the sarin simulant agent dimethyl methyl phosphonate (DMMP) by anchoring N1-(3-trimethoxysilylpropyl) diethylenetriamine (ATS)/silver nanoparticle (AgNP) nanocomposites on CSs using ATS as the stabilizer and coupling agent. Simultaneously, the binding mode and reaction mechanics between the AgNP, ATS, and CS were confirmed by XPS. The modified CSs exhibited good uniformity, stability, and adsorption capability for SERS measurements, enabling the adsorption and detection of DMMP residue from an irregular surface via a simple swabbing process, with a detection limit of 1 g/L. The relative standard deviations (RSDs) of RSD710 = 5.6% had high reproducibility. In this research, the fabrication method could easily be extended to other cellulose compounds, such as natural fibers and paper. Furthermore, the versatile SERS CSs can be used for the on-site detection of DMMP, particularly in civil and defense applications, to guarantee food security and the health of the population. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Health and Medicine)
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