molecules-logo

Journal Browser

Journal Browser

Synthesis and Separation of Optically Active Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 2745

Special Issue Editor


E-Mail Website
Guest Editor
Department of Organic Chemistry and Technology, Budapest University of Technology, 1111, Budafoki út 8, Budapest, Hungary
Interests: resolution; enantiomers; diastereomers; racemate and conglomerate behavior; memory of enantiomers; eutectic composition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A significant proportion of active pharmaceutical ingredients on the market are optically active compounds. However, enantiomers can have different or even opposite therapeutic effects, and the preparation of pure enantiomers is increasingly demanded in both academia and the pharmaceutical industry. Despite unprecedented advances in enantioselective synthesis and separation techniques, the large-scale production of enantiopure substances, as required by the pharmaceutical and pesticide industries, is still heavily dependent upon the separation of diastereomers obtained from enantiomers and an optically active resolving agent.

This Special Issue on “Synthesis and Separation of Optically Active Compounds” welcomes original research articles and reviews on the preparation of pure enantiomers by new or “traditional” methods.  The presentation of new techniques and new observations is welcome as well. As these optically active compounds are part of our daily lives, the observations, experiences, and connections made during their preparation may be of interest to all chemists.

Prof. Dr. Elemér Fogassy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • resolution
  • selective synthesis
  • optically active compounds
  • flow chemistry
  • new methods for separation of enantiomers
  • optimalization of conditions
  • advanced technics

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

20 pages, 7481 KiB  
Article
Optical Resolution of Two Pharmaceutical Bases with Various Uses of Tartaric Acid Derivatives and Their Sodium Salts: Racemic Ephedrine and Chloramphenicol Base
by Dorottya Fruzsina Bánhegyi, Elemér Fogassy, János Madarász and Emese Pálovics
Molecules 2022, 27(10), 3134; https://doi.org/10.3390/molecules27103134 - 13 May 2022
Cited by 5 | Viewed by 2301
Abstract
The optically active dibenzoyltartaric acid, tartaric acid, and its sodium salts were successfully applied to the optical resolution of (1R,2S)(1S,2R)-2-(methylamino)-1-phenylpropan-1-ol (EPH) and (1R,2R)(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (AD [...] Read more.
The optically active dibenzoyltartaric acid, tartaric acid, and its sodium salts were successfully applied to the optical resolution of (1R,2S)(1S,2R)-2-(methylamino)-1-phenylpropan-1-ol (EPH) and (1R,2R)(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (AD) as resolving agents. It was observed that both compounds’ resolution using a mixture of salts of quasi-racemic resolving agents showed a change in chiral recognition under the same conditions compared to the result of the use of the single enantiomeric resolving agent. The changes are followed by detailed analytical (XRD, FTIR, and DSC) studies. Meanwhile, the DASH indexing software package was also tested on powder XRD patterns of pure initial materials and intermediate salt samples of high diastereomeric excess. Full article
(This article belongs to the Special Issue Synthesis and Separation of Optically Active Compounds)
Show Figures

Figure 1

Back to TopTop