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Synthesis and Applications of Fluorescent Probes

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 482

Special Issue Editors


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ChiBioFarAm Department, University of Messina, 98166 Messina, Italy
Interests: organic synthesis; luminescent probes; carbohydrates; bioactive compounds; oligo phenylene ethynylene; sulfenic acids
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Special Issue Information

Dear Colleagues,

The use of fluorescent probes in the field of applied science has become increasingly prominent in the past decade. Their sensitivity and selectivity have led them to become one of the most commonly used analytical tools in environmental science, the development of sensing agents for the detection of ions and organic molecules, the study of physiological mechanisms at the cellular level, biotechnology, drug discovery and theranostics. Identifying the best tools for their synthesis, purification and characterization is the key to their efficient use.

For this Special Issue, we encourage authors to submit studies regarding the organic synthesis of fluorescent probes and their use in the applied sciences.

Dr. Anna Barattucci
Dr. Chiara Maria Antonietta Gangemi
Prof. Dr. Paola Bonaccorsi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic synthesis
  • organic fluorescent probe
  • fluorophores
  • sensors
  • bioimaging
  • photosensitizers

Published Papers (1 paper)

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Research

13 pages, 2743 KiB  
Article
Synthesis of Bodipy-Tagged Galactoconjugates and Evaluation of Their Antibacterial Properties
by Chiara Maria Antonietta Gangemi, Maura Monforte, Antonino Arrigo, Paola Maria Bonaccorsi, Sabrina Conoci, Antonella Iaconis, Fausto Puntoriero, Domenico Franco and Anna Barattucci
Molecules 2024, 29(10), 2299; https://doi.org/10.3390/molecules29102299 - 14 May 2024
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Abstract
As a development of our research on biocompatible glycoconjugate probes and specifically multi-chromophoric systems, herein, we report the synthesis and early bactericidal tests of two luminescent glycoconjugates whose basic structure is characterized by two boron dipyrromethene difluoride (BODIPY) moieties and three galactoside rings [...] Read more.
As a development of our research on biocompatible glycoconjugate probes and specifically multi-chromophoric systems, herein, we report the synthesis and early bactericidal tests of two luminescent glycoconjugates whose basic structure is characterized by two boron dipyrromethene difluoride (BODIPY) moieties and three galactoside rings mounted on an oligophenylene ethynylene (OPE) skeleton. BODIPY fluorophores have found widespread application in many branches of biology in the last few decades. In particular, molecular platforms showing two different BODIPY groups have unique photophysical behavior useful in fluorescence imaging. Construction of the complex architecture of the new probes is accomplished through a convergent route that exploits a series of copper-free Heck–Cassar–Sonogashira cross-couplings. The great emergency due to the proliferation of bacterial infections, in conjunction with growing antibiotic resistance, requires the production of new multifunctional drugs and efficient methods for their targeted delivery to control bacteria-associated diseases. Preliminary studies of the glycoconjugate properties as antibacterial agents against representatives of Gram-negative (P. aeruginosa) and Gram-positive (S. aureus) pathogens, which are associated with chronic infections, indicated significant bactericidal activity ascribable to their structural features. Full article
(This article belongs to the Special Issue Synthesis and Applications of Fluorescent Probes)
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