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Asymmetric Synthesis, Chiral Amplification/Enrichment, and Bioactive Chiral Compound Investigation

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 1794

Special Issue Editor


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Guest Editor
School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China
Interests: absolute configuration determination of chiral (natural) products; asymmetric synthesis; chiral enrichment and amplification; chiral bioactive alkaloids; chiral catalysts

Special Issue Information

Dear Colleagues,

Chiral compounds are important elements in pharmaceuticals, materials, as well as being involved in the origins of life. This Special Issue focuses on the organic stereochemistry study. It contains the chiral catalysts used in asymmetric synthesis of bioactive compounds, chiral enrichment or amplification, the isolation of bioactive chiral compounds and their absolute configuration assignments. Some chiral material characteristics may be included since many chiral materials may be applied for pharmaceutical use. Theoretical study combined with the experimental study are encouraged in the Special Issue. Reviews related in the organic stereochemistry are also welcome.

Dr. Huajie Zhu
Guest Editor

Manuscript Submission Information

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Keywords

  • chiral bioactive compounds
  • absolute configuration
  • chiral amplification or/and enrichment
  • asymmetric synthesis
  • chiral drug

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Published Papers (1 paper)

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Research

14 pages, 4527 KiB  
Article
Effusanin B Inhibits Lung Cancer by Prompting Apoptosis and Inhibiting Angiogenesis
by Jiantong Hou, Ying Li, Honghong Xing, Ruyu Cao, Xiaomeng Jin, Jing Xu and Yuanqiang Guo
Molecules 2023, 28(23), 7682; https://doi.org/10.3390/molecules28237682 - 21 Nov 2023
Cited by 3 | Viewed by 1470
Abstract
Cancer is one of the deadliest human diseases, causing high rates of illness and death. Lung cancer has the highest mortality rate among all malignancies worldwide. Effusanin B, a diterpenoid derived from Isodon serra, showed therapeutic potential in treating non-small-cell lung cancer [...] Read more.
Cancer is one of the deadliest human diseases, causing high rates of illness and death. Lung cancer has the highest mortality rate among all malignancies worldwide. Effusanin B, a diterpenoid derived from Isodon serra, showed therapeutic potential in treating non-small-cell lung cancer (NSCLC). Further research on the mechanism indicated that effusanin B inhibited the proliferation and migration of A549 cells both in vivo and in vitro. The in vitro activity assay demonstrated that effusanin B exhibited significant anticancer activity. Effusanin B induced apoptosis, promoted cell cycle arrest, increased the production of reactive oxygen species (ROS), and altered the mitochondrial membrane potential (MMP). Based on mechanistic studies, effusanin B was found to inhibit the proliferation and migration of A549 cells by affecting the signal transducer and activator of transcription 3 (STAT3) and focal adhesion kinase (FAK) pathways. Moreover, effusanin B inhibited tumor growth and spread in a zebrafish xenograft model and demonstrated anti-angiogenic effects in a transgenic zebrafish model. Full article
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