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Bioactive Material for Wound Healing, Tissue Engineering and Regenerative Medicine
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Bioactive Material for Wound Healing, Tissue Engineering and Regenerative Medicine

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 9312

Special Issue Editor

Dr. Dinesh Patel

E-Mail Website
Guest Editor
Department of Biosystems Engineering, Kangwon National University, Chuncheon, Korea
Interests: biomaterials; nanocellulose; tissue engineering; drug delivery; wound healing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The global demand for bioactive biomaterials for regenerating damaged tissues through infections or trauma is increasing due to the desired composition and structure, adequate mechanical strength, and biocompatibility. The design and development of suitable biomaterials enable new horizons in regenerative tissue fields. Various techniques such as spin coating, electrospinning, and three-dimensional (3D) printing are widely explored to develop a bioactive platform for tissue engineering applications. Different materials, including ceramics, bioactive glasses, polymers, hydrogels, and composites, are frequently applied in wound healing, tissue engineering, and regenerative medicine. Biomaterials, cells, and growth factors play significant roles in regenerating lost and damaged tissues. Bioactive materials have the potential to trigger cell behaviors, which influence tissue regeneration.

Furthermore, microbial infection is highly possible during wound healing or regenerative processes. Therefore, the development of multifunctional bioactive materials with antibacterial, antioxidant, adhesiveness, self-healing, etc. are highly desirable for tissue engineering applications. The Special Issue explores the design and development of new bioactive biomaterials for improved wound healing, tissue engineering, and regenerative medicine. We anticipate that this Special Issue will include the current state-of-the-art and explore a wide range of applications.

Dr. Dinesh Patel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive materials
  • stem cells
  • wound healing
  • tissue engineering
  • regenerative medicine

Published Papers (3 papers)

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Research

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21 pages, 18709 KiB  
Article
Rosmarinic Acid-Grafted Dextran/Gelatin Hydrogel as a Wound Dressing with Improved Properties: Strong Tissue Adhesion, Antibacterial, Antioxidant and Anti-Inflammatory
by Yi Yin, Qianqian Xu, Xin Wei, Qianyun Ma, Dongsheng Li and Juanjuan Zhao
Molecules 2023, 28(10), 4034; https://doi.org/10.3390/molecules28104034 - 11 May 2023
Cited by 6 | Viewed by 2037
Abstract
Designing a strong tissue adhesive and multifunctional hydrogel dressing for various skin injuries is still a significant challenge. Based on the bioactive activities of rosmarinic acid (RA) and its catechol structure being similar to dopamine, RA-grafted dextran/gelatin hydrogel (ODex−AG−RA) was designed and systemically [...] Read more.
Designing a strong tissue adhesive and multifunctional hydrogel dressing for various skin injuries is still a significant challenge. Based on the bioactive activities of rosmarinic acid (RA) and its catechol structure being similar to dopamine, RA-grafted dextran/gelatin hydrogel (ODex−AG−RA) was designed and systemically characterized in this study. The ODex−AG−RA hydrogel exhibited excellent physicochemical properties, including fast gelation time (61.6 ± 2.8 s), strong adhesive strength (27.30 ± 2.02 kPa) and enhanced mechanical properties (1.31 × 104 Pa of G′). The examination of hemolysis and co-culturing with L929 cells showed the strong in vitro biocompatibility of ODex−AG−RA hydrogels. The ODex−AG−RA hydrogels exhibited a 100% mortality rate against S. aureus and at least 89.7% against E. coli in vitro. In vivo evaluation for efficacy in skin wound healing was carried out in a rat model of full-thickness skindefect. The amount of collagen deposition and CD31 on wounds in the two ODex−AG−RA−1 groups on day 14 was 4.3 times and 2.3 times of that in the control group, respectively. Furthermore, the mechanism of ODex−AG−RA−1 for promoting wound healing was proved to be related to its anti-inflammatory properties by adjusting the expression of inflammatory cytokines (TNF-α and CD163) and reducing the level of oxidative stress (MDA and H2O2). Overall, this study demonstrated the wound-healing efficacy of RA-grafted hydrogels for the first time. ODex−AG−RA−1 hydrogel, due to its adhesive, anti-inflammatory, antibacterial and antioxidative activities, was a promising candidate as a wound dressing. Full article
(This article belongs to the Special Issue Bioactive Material for Wound Healing, Tissue Engineering and Regenerative Medicine)
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Review

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27 pages, 1646 KiB  
Review
The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels
by Anna J. Morwood, Ikhlas A. El-Karim, Susan A. Clarke and Fionnuala T. Lundy
Molecules 2023, 28(12), 4616; https://doi.org/10.3390/molecules28124616 - 7 Jun 2023
Cited by 4 | Viewed by 2463
Abstract
To create functional tissue engineering scaffolds, biomaterials should mimic the native extracellular matrix of the tissue to be regenerated. Simultaneously, the survival and functionality of stem cells should also be enhanced to promote tissue organisation and repair. Hydrogels, but in particular, peptide hydrogels, [...] Read more.
To create functional tissue engineering scaffolds, biomaterials should mimic the native extracellular matrix of the tissue to be regenerated. Simultaneously, the survival and functionality of stem cells should also be enhanced to promote tissue organisation and repair. Hydrogels, but in particular, peptide hydrogels, are an emerging class of biocompatible scaffolds which act as promising self-assembling biomaterials for tissue engineering and regenerative therapies, ranging from articular cartilage regeneration at joint defects, to regenerative spinal cord injury following trauma. To enhance hydrogel biocompatibility, it has become imperative to consider the native microenvironment of the site for regeneration, where the use of functionalised hydrogels with extracellular matrix adhesion motifs has become a novel, emerging theme. In this review, we will introduce hydrogels in the context of tissue engineering, provide insight into the complexity of the extracellular matrix, investigate specific adhesion motifs that have been used to generate functionalised hydrogels and outline their potential applications in a regenerative medicine setting. It is anticipated that by conducting this review, we will provide greater insight into functionalised hydrogels, which may help translate their use towards therapeutic roles. Full article
(This article belongs to the Special Issue Bioactive Material for Wound Healing, Tissue Engineering and Regenerative Medicine)
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16 pages, 2683 KiB  
Review
Construction of Smart Biomaterials for Promoting Diabetic Wound Healing
by Chan Huang, Weiyan Yuan, Jun Chen, Lin-Ping Wu and Tianhui You
Molecules 2023, 28(3), 1110; https://doi.org/10.3390/molecules28031110 - 22 Jan 2023
Cited by 17 | Viewed by 4357
Abstract
Diabetes mellitus is a complicated metabolic disease that has become one of the fastest-growing health crises in modern society. Diabetic patients may suffer from various complications, and diabetic foot is one of them. It can lead to increased rates of lower-extremity amputation and [...] Read more.
Diabetes mellitus is a complicated metabolic disease that has become one of the fastest-growing health crises in modern society. Diabetic patients may suffer from various complications, and diabetic foot is one of them. It can lead to increased rates of lower-extremity amputation and mortality, even seriously threatening the life and health of patients. Because its healing process is affected by various factors, its management and treatment are very challenging. To address these problems, smart biomaterials have been developed to expedite diabetic wound closure and improve treatment outcomes. This review begins with a discussion of the basic mechanisms of wound recovery and the limitations of current dressings used for diabetic wound healing. Then, the categories and characteristics of the smart biomaterial scaffolds, which can be utilized as a delivery system for drugs with anti-inflammatory activity, bioactive agency, and antibacterial nanoparticles for diabetic wound treatment were described. In addition, it can act as a responsive system to the stimulus of the pH, reactive oxygen species, and glucose concentration from the wound microenvironment. These results show that smart biomaterials have an enormous perspective for the treatment of diabetic wounds in all stages of healing. Finally, the advantages of the construction of smart biomaterials are summarized, and possible new strategies for the clinical management of diabetic wounds are proposed. Full article
(This article belongs to the Special Issue Bioactive Material for Wound Healing, Tissue Engineering and Regenerative Medicine)
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