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Bioactive Food Compounds and Their Health Benefits

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 1836

Special Issue Editor


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Guest Editor
1. Department of Food and Nutrition, University of Kalisz, W. Bogusławskiego 4 Square, 62-800 Kalisz, Poland
2. Department of Production Engineering, Wroclaw University of Economics and Business, Komandorska 118/120, 53‑345 Wrocław, Poland
Interests: nutraceuticals and functional foods; medicinal plants; bioactive compounds; HPLC; LC-MS; nutrition; antioxidant agent; prebiotics; probiotics; symbiotics; bioavailability in vitro
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Special Issue Information

Dear Colleagues,

There is no doubt that a diet rich in food of plant origin is an important element in the prevention of lifestyle diseases. Modern lifestyles and exposure to extreme and long-term stress contribute to the formation of excess free radicals that disturb redox homeostasis, as well as to disorders of intestinal microflora (i.e., intestinal dysbiosis). Reactive oxygen species are often a risk factor for the development of chronic inflammation responsible for pathological lesions in the global population in the 21st century. In this context, bioactive compounds present in plants, which have strong antioxidant properties that regulate redox homeostasis and have a beneficial effect as prebiotics, are perceived as a rational and effective solution for reducing oxidative stress. The latest scientific reports indicate that the consumption of bioactive compounds (BCs) and BC-rich foods has increased dynamically due to their documented pharmacological properties, including their antioxidative, anti-inflammatory, anti-obesity, anti-diabetic, and anti-carcinogenic properties. As a result, consumer awareness about the important role of these high-quality products in human nutrition, health, and the prevention of diseases has increased. Therefore, it is our pleasure to present this Special Issue of Molecules entitled “Bioactive Food Compounds and Their Health Benefits”. For this Special Issue, I encourage you to publish your activities aimed at presenting the latest scientific news, insights, and advances in the field of bioactive compounds, e.g., polyphenolic compounds, carotenoids, vitamins, proteins, and their impact on health benefits. The information presented will certainly attract considerable interest among a large group of our readers from different disciplines and research fields.

Dr. Sabina Lachowicz-Wiśniewska
Guest Editor

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Keywords

  • polyphenolic compounds
  • bioactive compound
  • natural products
  • food safety
  • phytochemicals
  • carotenoids
  • LC-MS/MS techniques
  • HPLC-DAD-MS
  • fruits, vegetables, and mushrooms
  • antioxidant compounds
  • functional food
  • prebiotics
  • health benefits

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Published Papers (2 papers)

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Research

25 pages, 2002 KB  
Article
Potential Nutraceutical Properties of Vicia faba L: LC-ESI-HR-MS/MS-Based Profiling of Ancient Faba Bean Varieties and Their Biological Activity
by Francesca Fantasma, Gilda D’Urso, Alessandra Capuano, Ester Colarusso, Michela Aliberti, Francesca Grassi, Maria Chiara Brunese, Gabriella Saviano, Vincenzo De Felice, Gianluigi Lauro, Alfonso Reginelli, Maria Giovanna Chini, Agostino Casapullo, Giuseppe Bifulco and Maria Iorizzi
Molecules 2026, 31(1), 184; https://doi.org/10.3390/molecules31010184 - 4 Jan 2026
Viewed by 482
Abstract
Vicia faba L. is a widely cultivated legume known to contain numerous specialised metabolites. In this study, the seed coats and cotyledons of two ancient V. faba L. varieties, historically consumed in southern Italy and distinguished by black and purple seed coats, were [...] Read more.
Vicia faba L. is a widely cultivated legume known to contain numerous specialised metabolites. In this study, the seed coats and cotyledons of two ancient V. faba L. varieties, historically consumed in southern Italy and distinguished by black and purple seed coats, were extracted using 80% methanol and 80% ethanol. Extracts were analysed for total polyphenol, flavonoid and proanthocyanidin contents, and antioxidant activity using DPPH, ABTS, and FRAP assays. The purple seed coats exhibited the highest levels of phenolics and antioxidant capacity, exceeding those of black seed coats. Next, liquid chromatography coupled with high-resolution mass spectrometry (LC-ESI-HR-MS) was used to characterise the bioactive metabolites in both seed coats and cotyledons. The purple variety showed a higher phytochemical content, with a greater level of flavonoids and proanthocyanidins in methanolic extract. Furthermore, the purple seed coat exhibited in vitro anti-inflammatory activity by inhibiting soluble epoxide hydrolase (sEH), a key enzyme in the arachidonic acid cascade, with an IC50 of 31.51 ± 1.16 µg/µL. Elemental analysis was performed for both varieties to assess their nutritional value. Specifically, the purple seed coats were found to represent a valuable source of bioactive compounds and micronutrients, highlighting their potential applications in nutraceutical, cosmetic, and food supplement sectors. Full article
(This article belongs to the Special Issue Bioactive Food Compounds and Their Health Benefits)
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19 pages, 1426 KB  
Article
Gingerol-Enriched Ginger Extract Effects on Anxiety-like Behavior in a Neuropathic Pain Model via Colonic Microbiome-Neuroimmune Modulation
by Roberto Mendóza, Julianna M. Santos, Xiaobo Liu, Moamen M. Elmassry, Guangchen Ji, Takaki Kiritoshi, Volker Neugebauer and Chwan-Li Shen
Molecules 2026, 31(1), 166; https://doi.org/10.3390/molecules31010166 - 1 Jan 2026
Viewed by 1142
Abstract
Growing evidence has revealed that gut dysbiosis is associated with the development of anxio-depressive disorders through mechanisms that involve neuroimmune signaling, neurotransmitter changes, and neuroplasticity in the brain. This study investigated the effects of gingerol-enriched ginger (GEG) on specifically anxiety-related neuroinflammation-, neuroimmunity-, neuroplasticity-, [...] Read more.
Growing evidence has revealed that gut dysbiosis is associated with the development of anxio-depressive disorders through mechanisms that involve neuroimmune signaling, neurotransmitter changes, and neuroplasticity in the brain. This study investigated the effects of gingerol-enriched ginger (GEG) on specifically anxiety-related neuroinflammation-, neuroimmunity-, neuroplasticity-, neurotransmission-, and neurotoxicity-associated genes in different brain regions, as well as on alterations linked to colonic microflora-driven dysbiosis, in the spinal nerve ligation (SNL) rat model of neuropathic pain (NP). Twenty-seven male rats were assigned to 3 groups: sham, SNL, and SNL-treated with GEG at 200 mg/kg body weight (SNL+200GEG) via oral gavage for 5 weeks. Anxiety-like behavior was assessed on the elevated plus maze (EPM). mRNA expression was assessed by qRT-PCR using respective primers. Correlation between behavioral parameters and colonic microbiome composition was analyzed using the Spearman rank correlation. The SNL+200GEG group demonstrated decreased anxiety-like behavior in the SNL model. Compared to the SNL group, the SNL+200GEG group had increased mRNA expression of NRF2 (amygdala: left), LXRα (amygdala: both sides), and CX3CR1 (amygdala: both sides, hippocampus: right). GEG modulated neuroplasticity as shown by increased gene expression of PGK1 (amygdala: right, hippocampus: both sides), MEK1 (frontal cortex: both sides), LDHA (frontal cortex: both sides), GPM6A (frontal cortex: both sides, amygdala: right, hippocampus: right, and hypothalamus), and GLUT1 (amygdala: right) as well by decreased gene expression of HIF1α (in all brain regions except for the hypothalamus). GEG modulated neurotransmission via clearance of excessive glutamate release as suggested by increased gene expression of SLC1A3 (frontal cortex: both sides, hippocampus: right) and via augmenting mGluR5 signaling as shown by increased gene expression of GRM5 (hippocampus: both sides, hypothalamus) as well as downregulation of KMO, HAAO, GRIN2B, and GRIN2C influencing downstream serotonergic neurotransmission and NMDA receptor-mediated glutamatergic pathways in different brain regions. GEG further alleviated neurotoxicity through downregulated gene expression of SIRT1, KMO, IDO1, and HAAO in different brain regions. Moreover, the increased relative abundance of Bilophila spp., accompanied by decreased time spent in the EPM open arms, suggests that increased Bilophila abundance increases anxiety-like behavior. GEG supplementation mitigated anxiety-like behavior in male rats with NP, at least in part, by reducing SNL-induced inflammatory sequelae-related mRNA gene expression in different brain regions. In addition, there is a positive correlation between the abundance of Bilophila wadsworthia and the degree of anxiety-like behavior. Full article
(This article belongs to the Special Issue Bioactive Food Compounds and Their Health Benefits)
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