Role of Fatty Acids in Health and Disease
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 408
Special Issue Editors
Interests: hepatic metabolism; hepatic oxidative stress and fatty acid metabolism; liver steatosis; dietary and nutritional intervention in liver diseases
Special Issues, Collections and Topics in MDPI journals
Interests: bioactive compounds (fatty acids and polyphenols) in obesity and NAFLD models; revalorization of agroindustrial byproducts into bioactive compounds (fatty acids and polyphenols)for functional ingredients development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Fatty acids are organic molecules that, depending on the number of carbon–carbon double bonds in their structure, are classified as saturated (no double bond), monounsaturated (one double bond) and polyunsaturated (two or more double bonds). Fatty acids are highly dense energy molecules, providing 9 kcal/g. Thus, sustained consumption of a high-fat diet has been associated with weight gain and obesity, and other chronic diseases. Nevertheless, dietary fat intake can produce different metabolic effects based on its fatty acid profile. In that context, fatty acids exert diverse physiological functions: they play a structural role (especially in cell membranes), regulate the development and growth of cells and tissues (e.g., the nervous system), assist in immune function, regulate the inflammatory response and act as transcription factors and ligands regulating gene expression. The excessive consumption of fats (especially saturated fatty acids) has been associated with a higher risk of developing multiple metabolic risk factors and pathologies such as obesity, non-alcoholic fatty liver disease, cardiovascular diseases and neurodegenerative disorders. However, the intake of specific fatty acids, such as monounsaturated (MUFA) or n-3 polyunsaturated fatty acids (n-3 PUFA), can contribute to preventing or reducing the risk of developing different pathologies, particularly cardiovascular or neurodegenerative diseases. This Special Issue of Molecules is devoted to recent advances in fatty acids in growth and development and the prevention and treatment of chronic diseases, identifying and discussing the molecular pathways that participate in these effects.
Dr. Rodrigo Valenzuela
Dr. Francisca Echeverria
Guest Editors
Manuscript Submission Information
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Keywords
- fatty acids and growth and development
- lipid mediators
- inflammatory response
- inflammation resolution
- fatty acids and oxidative stress
- cardiovascular disease
- obesity
- fatty acids and NAFLD
- brain aging and neurodegenerative disease
- fatty acids and respiratory disease
