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Molecules
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New Insights in Antimicrobial Nanomaterials
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New Insights in Antimicrobial Nanomaterials

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 10034

Special Issue Editor

Prof. Dr. Mingdi Yan

E-Mail Website
Guest Editor
Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA
Interests: antimicrobial; nanomaterials; surface, biointerface; glyconanomaterials; bioconjugation chemistry; graphene chemistry

Special Issue Information

Dear Colleagues,

The increasing prevalence of antimicrobial resistance (AMR) against the majority of existing antibiotics has generated a pressing global healthcare crisis. Certain highly resistant bacteria have acquired multiple resistance mechanisms against all available antibiotics. Antimicrobial nanomaterials have emerged as unique candidates in the fight against AMR. They often have unique mechanisms that differ from conventional organic pharmaceuticals. This feature is especially attractive in the present era where many existing drugs have become obsolete due to drug resistance. This Special Issue focuses on recent developments in antimicrobial nanomaterials. The scope will include metal nanomaterials, metal oxide nanomaterials, and organic and polymer nanomaterials. Topics include the synthesis and characterization of novel antimicrobial nanomaterials, methods for the evaluation of antimicrobial activities of antimicrobial nanomaterials, and the mechanisms of actions. We welcome original research articles, reviews on these topics.

Prof. Dr. Mingdi Yan
Guest Editor

Manuscript Submission Information

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Keywords

  • antimicrobial nanomaterials
  • antimicrobial nanoparticles
  • antimicrobial nanoclusters
  • microbe-nanomaterial interactions
  • mechanisms
  • bacteria
  • viruses

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Published Papers (4 papers)

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Research

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13 pages, 4498 KiB  
Article
Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm
by Jinghong Shi, Yucheng Wang, Wei He, Ziyue Ye, Mengli Liu, Zheng Zhao, Jacky Wing Yip Lam, Pengfei Zhang, Ryan Tsz Kin Kwok and Ben Zhong Tang
Molecules 2023, 28(14), 5368; https://doi.org/10.3390/molecules28145368 - 12 Jul 2023
Cited by 3 | Viewed by 1716
Abstract
Biofilm-associated infections exert more severe and harmful attacks on human health since they can accelerate the generation and development of the antibiotic resistance of the embedded bacteria. Anti-biofilm materials and techniques that can eliminate biofilms effectively are in urgent demand. Therefore, we designed [...] Read more.
Biofilm-associated infections exert more severe and harmful attacks on human health since they can accelerate the generation and development of the antibiotic resistance of the embedded bacteria. Anti-biofilm materials and techniques that can eliminate biofilms effectively are in urgent demand. Therefore, we designed a type I photosensitizer (TTTDM) with an aggregation-induced emission (AIE) property and used F-127 to encapsulate the TTTDM into nanoparticles (F-127 AIE NPs). The NPs exhibit highly efficient ROS generation by enhancing intramolecular D–A interaction and confining molecular non-radiative transitions. Furthermore, the NPs can sufficiently penetrate the biofilm matrix and then detect and eliminate mature bacterial biofilms upon white light irradiation. This strategy holds great promise for the rapid detection and eradication of bacterial biofilms. Full article
(This article belongs to the Special Issue New Insights in Antimicrobial Nanomaterials)
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13 pages, 1634 KiB  
Article
Synthesis of Glycopolymer Micelles for Antibiotic Delivery
by Xuan Chen, Bin Wu, Harini A. Perera and Mingdi Yan
Molecules 2023, 28(10), 4031; https://doi.org/10.3390/molecules28104031 - 11 May 2023
Cited by 2 | Viewed by 2012
Abstract
In this work, we designed biodegradable glycopolymers consisting of a carbohydrate conjugated to a biodegradable polymer, poly(lactic acid) (PLA), through a poly(ethylene glycol) (PEG) linker. The glycopolymers were synthesized by coupling alkyne end-functionalized PEG-PLA with azide-derivatized mannose, trehalose, or maltoheptaose via the click [...] Read more.
In this work, we designed biodegradable glycopolymers consisting of a carbohydrate conjugated to a biodegradable polymer, poly(lactic acid) (PLA), through a poly(ethylene glycol) (PEG) linker. The glycopolymers were synthesized by coupling alkyne end-functionalized PEG-PLA with azide-derivatized mannose, trehalose, or maltoheptaose via the click reaction. The coupling yield was in the range of 40–50% and was independent of the size of the carbohydrate. The resulting glycopolymers were able to form micelles with the hydrophobic PLA in the core and the carbohydrates on the surface, as confirmed by binding with the lectin Concanavalin A. The glycomicelles were ~30 nm in diameter with low size dispersity. The glycomicelles were able to encapsulate both non-polar (rifampicin) and polar (ciprofloxacin) antibiotics. Rifampicin-encapsulated micelles were much smaller (27–32 nm) compared to the ciprofloxacin-encapsulated micelles (~417 nm). Moreover, more rifampicin was loaded into the glycomicelles (66–80 μg/mg, 7–8%) than ciprofloxacin (1.2–2.5 μg/mg, 0.1–0.2%). Despite the low loading, the antibiotic-encapsulated glycomicelles were at least as active or 2–4 times more active than the free antibiotics. For glycopolymers without the PEG linker, the antibiotics encapsulated in micelles were 2–6 times worse than the free antibiotics. Full article
(This article belongs to the Special Issue New Insights in Antimicrobial Nanomaterials)
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13 pages, 2720 KiB  
Article
Novel Carboxylic Acid-Capped Silver Nanoparticles as Antimicrobial and Colorimetric Sensing Agents
by Muhammad Imran Irfan, Fareeha Amjad, Azhar Abbas, Muhammad Fayyaz ur Rehman, Fariha Kanwal, Muhammad Saeed, Sami Ullah and Changrui Lu
Molecules 2022, 27(11), 3363; https://doi.org/10.3390/molecules27113363 - 24 May 2022
Cited by 26 | Viewed by 2988
Abstract
The present work reports the synthesis, characterization, and antimicrobial activities of adipic acid-capped silver nanoparticles (AgNPs@AA) and their utilization for selective detection of Hg2+ ions in an aqueous solution. The AgNPs were synthesized by the reduction of Ag+ ions with NaBH [...] Read more.
The present work reports the synthesis, characterization, and antimicrobial activities of adipic acid-capped silver nanoparticles (AgNPs@AA) and their utilization for selective detection of Hg2+ ions in an aqueous solution. The AgNPs were synthesized by the reduction of Ag+ ions with NaBH4 followed by capping with adipic acid. Characterization of as-synthesized AgNPs@AA was carried out by different techniques, including UV–Visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Dynamic Light Scattering (DLS), and zeta potential (ZP). In the UV–Vis absorption spectrum, the characteristic absorption band for AgNPs was observed at 404 nm. The hydrodynamic size of as-synthesized AgNPs was found to be 30 ± 5.0 nm. ZP values (−35.5 ± 2.4 mV) showed that NPs possessed a negative charge due to carboxylate ions and were electrostatically stabilized. The AgNPs show potential antimicrobial activity against clinically isolated pathogens. These AgNPs were found to be selectively interacting with Hg2+ in an aqueous solution at various concentrations. A calibration curve was constructed by plotting concentration as abscissa and absorbance ratio (AControl − AHg/AControl) as ordinate. The linear range and limit of detection (LOD) of Hg2+ were 0.6–1.6 μM and 0.12 μM, respectively. A rapid response time of 4 min was found for the detection of Hg2+ by the nano-probe. The effect of pH and temperature on the detection of Hg2+ was also investigated. The nano-probe was successfully applied for the detection of Hg2+ from tap and river water Full article
(This article belongs to the Special Issue New Insights in Antimicrobial Nanomaterials)
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Review

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21 pages, 5537 KiB  
Review
AIEgen-Based Nanomaterials for Bacterial Imaging and Antimicrobial Applications: Recent Advances and Perspectives
by Zipeng Shen, Yinzhen Pan, Dingyuan Yan, Dong Wang and Ben Zhong Tang
Molecules 2023, 28(6), 2863; https://doi.org/10.3390/molecules28062863 - 22 Mar 2023
Cited by 5 | Viewed by 2578
Abstract
Microbial infections have always been a thorny problem. Multi-drug resistant (MDR) bacterial infections rendered the antibiotics commonly used in clinical treatment helpless. Nanomaterials based on aggregation-induced emission luminogens (AIEgens) recently made great progress in the fight against microbial infections. As a family of [...] Read more.
Microbial infections have always been a thorny problem. Multi-drug resistant (MDR) bacterial infections rendered the antibiotics commonly used in clinical treatment helpless. Nanomaterials based on aggregation-induced emission luminogens (AIEgens) recently made great progress in the fight against microbial infections. As a family of photosensitive antimicrobial materials, AIEgens enable the fluorescent tracing of microorganisms and the production of reactive oxygen (ROS) and/or heat upon light irradiation for photodynamic and photothermal treatments targeting microorganisms. The novel nanomaterials constructed by combining polymers, antibiotics, metal complexes, peptides, and other materials retain the excellent antimicrobial properties of AIEgens while giving other materials excellent properties, further enhancing the antimicrobial effect of the material. This paper reviews the research progress of AIEgen-based nanomaterials in the field of antimicrobial activity, focusing on the materials’ preparation and their related antimicrobial strategies. Finally, it concludes with an outlook on some of the problems and challenges still facing the field. Full article
(This article belongs to the Special Issue New Insights in Antimicrobial Nanomaterials)
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