Asymmetric Synthesis, Enantioselective Analysis and Chiral Recognition
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 5579
Special Issue Editor
Interests: chirality; enantioselective nano chromatography; asymmetric catalysis; chiral analysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The importance of chirality and its medical impact has steadily increased in the last decades and it is currently a central hot topic in organic and pharmaceutical chemistry, and in particular, the development of new drugs. Recently the first deuterated chiral drug was approved by US Food and Drug Administration (FDA) for therapeutic use as a long acting drug used in the treatment of chorea in Huntington’s disease (HD). Austedo or deutetrabenazine is the deuterated version of the chiral tetrabenazine drug. To establish that its beneficial therapeutic actions are enantiospecific, a practical total synthetic route was developed to yield separate enantiomeric forms, allowing their chemical and pharmacological characterization. The latter is a mandatory FDA requirement for all new drugs where stereochemistry is involved. Similarly, many chiral drugs in the market involve asymmetric or enantioselective synthesis, chiral or enantioselective analysis, and the understanding of the chiral recognition mechanism.
This Special Issue aims to deal with all sorts of chirality, from asymmetric/enantioselective synthesis to chiral analysis with an understanding of the chiral recognition mechanism. Theoretical, fundamental, practical studies in multidisciplinary approaches are all welcome for consideration. Contributions may be in the form of original research or review articles covering the broad scope of chirality, its impact, and applications.
Prof. Dr. Ashraf Ghanem
Guest Editor
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Keywords
- chirality
- enantioselective chromatography
- chiral separation
- chiral recognition
- asymmetric synthesis
- asymmetric catalysis
- chiral recognition
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