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Natural Compounds: An Antidiabetic and Anticancer Agents
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Natural Compounds: An Antidiabetic and Anticancer Agents

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 24546

Special Issue Editors

Dr. Arpita Roy

E-Mail Website
Guest Editor
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India
Interests: plant biotechnology; medicinal plants/phytocompounds; environmental biotechnology; microbiology; nanobiotechnology
Dr. Ram Prasad

E-Mail Website
Guest Editor
Department of Botany, Mahatma Gandhi Central University, Motihari, India
Interests: microbiology; nanotechnology; plant microbe interaction; microbial nanobiotechnology; agriculture sustainability
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural compounds from various organisms have been shown to possess health benefits for humans. According to the estimation of the World Health Organization, in developing countries, 80% of the population still depends on traditional medicines, which are mostly prepared from plants for the prevention or treatment of various diseases. Natural products (NPs) from plants, fungi, and microbes have played very important roles in modern drug discovery. An increasing number of promising discoveries in this field are published in natural product periodicals such as Molecules every year. This Special Issue of Molecules will feature some of the recent and most promising findings in the area of antidiabetic and anticancer agents from natural sources. Diabetes is one of the chronic diseases of metabolism and is upsurging across every continent in the world. Treatment to prevent this disease is an important challenge for researchers. Similarly, cancer is another disease in which potential research is ongoing. Bioactive compounds from a natural source are a paramount source for potential lead candidates’ discovery, which can play an utmost role in drug discovery and drug development projects. They are an alternative source to overcome this problem, as they contain various compounds that show protective effects against various diseases. Natural product-derived nanomaterials have also shown potential application in diabetes and cancer management. Hence, research into bioactive compounds and nanomaterials from natural sources may contribute to the development of effective and novel alternative therapeutics in the search for side effects, eco-friendly, low-cost, and fast treatment. This Special Issue aims to collect original research and review articles regarding research into bioactive compounds from natural sources in diabetes and cancer management.

Dr. Arpita Roy
Dr. Ram Prasad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug development from natural products
  • mechanism of action
  • therapeutic application
  • in silico analysis
  • drug repositioning of natural products
  • biosynthesis of natural products-derived drugs
  • production of bioactive natural products by in vitro culture
  • nanomaterials for diseases management

Published Papers (4 papers)

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Research

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10 pages, 1412 KiB  
Article
Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts
by Saima Muzammil, Yunsheng Wang, Muhammad Hussnain Siddique, Errum Zubair, Sumreen Hayat, Muhammad Zubair, Arpita Roy, Rabia Mumtaz, Muhammad Azeem, Talha Bin Emran and Muhammad Qasim Shahid
Molecules 2022, 27(19), 6263; https://doi.org/10.3390/molecules27196263 - 23 Sep 2022
Cited by 10 | Viewed by 1733
Abstract
Coronopus didymus (Brassicaceae) commonly known as lesser swine cress has been reported to be used for its pharmacological activities. This study aimed to evaluate the medicinal potential of C. didymus extracts against cancer, diabetes, infectious bacteria and oxidative stress and the identification of [...] Read more.
Coronopus didymus (Brassicaceae) commonly known as lesser swine cress has been reported to be used for its pharmacological activities. This study aimed to evaluate the medicinal potential of C. didymus extracts against cancer, diabetes, infectious bacteria and oxidative stress and the identification of bioactive compounds present in these extracts. The effects of using different solvents for the extraction of C. didymus on the contents of major polyphenols and biological activities were investigated. Plant sample was shade dried, ground to a fine powder, and then soaked in pure acetone, ethanol and methanol. The highest contents of major polyphenols were found in methanol-based extract, i.e., chlorogenic acid, HB acid, kaempferol, ferulic acid, quercetin and benzoic acid with 305.02, 12.42, 11.5, 23.33, 975.7 and 428 mg/g of dry weight, respectively, followed by ethanol- and acetone-based extracts. The methanol-based extract also resulted in the highest antioxidant activities (56.76%), whereas the highest antiproliferative (76.36) and alpha glucosidase inhabitation (96.65) were demonstrated in ethanol-based extracts. No antibacterial property of C. didymus was observed against all the tested strains of bacteria. Further studies should be focused on the identification of specific bioactive compounds responsible for pharmacological activities. Full article
(This article belongs to the Special Issue Natural Compounds: An Antidiabetic and Anticancer Agents)
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Review

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32 pages, 3077 KiB  
Review
Natural Small Molecules in Gastrointestinal Tract and Associated Cancers: Molecular Insights and Targeted Therapies
by Fahadul Islam, Saikat Mitra, Talha Bin Emran, Zidan Khan, Nikhil Nath, Rajib Das, Rohit Sharma, Ahmed Abdullah Al Awadh, Moon Nyeo Park and Bonglee Kim
Molecules 2022, 27(17), 5686; https://doi.org/10.3390/molecules27175686 - 3 Sep 2022
Cited by 10 | Viewed by 2698
Abstract
Gastric cancer is one of the most common cancers of the gastrointestinal tract. Although surgery is the primary treatment, serious maladies that dissipate to other parts of the body may require chemotherapy. As there is no effective procedure to treat stomach cancer, natural [...] Read more.
Gastric cancer is one of the most common cancers of the gastrointestinal tract. Although surgery is the primary treatment, serious maladies that dissipate to other parts of the body may require chemotherapy. As there is no effective procedure to treat stomach cancer, natural small molecules are a current focus of research interest for the development of better therapeutics. Chemotherapy is usually used as a last resort for people with advanced stomach cancer. Anti-colon cancer chemotherapy has become increasingly effective due to drug resistance and sensitivity across a wide spectrum of drugs. Naturally-occurring substances have been widely acknowledged as an important project for discovering innovative medications, and many therapeutic pharmaceuticals are made from natural small molecules. Although the beneficial effects of natural products are as yet unknown, emerging data suggest that several natural small molecules could suppress the progression of stomach cancer. Therefore, the underlying mechanism of natural small molecules for pathways that are directly involved in the pathogenesis of cancerous diseases is reviewed in this article. Chemotherapy and molecularly-targeted drugs can provide hope to colon cancer patients. New discoveries could help in the fight against cancer, and future stomach cancer therapies will probably include molecularly formulated drugs. Full article
(This article belongs to the Special Issue Natural Compounds: An Antidiabetic and Anticancer Agents)
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27 pages, 1061 KiB  
Review
Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint
by Md. Rezaul Islam, Fahadul Islam, Mohamed H. Nafady, Muniya Akter, Saikat Mitra, Rajib Das, Humaira Urmee, Sheikh Shohag, Aklima Akter, Kumarappan Chidambaram, Fahad A. Alhumaydhi, Talha Bin Emran and Simona Cavalu
Molecules 2022, 27(7), 2165; https://doi.org/10.3390/molecules27072165 - 27 Mar 2022
Cited by 63 | Viewed by 8306
Abstract
Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of [...] Read more.
Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates. Full article
(This article belongs to the Special Issue Natural Compounds: An Antidiabetic and Anticancer Agents)
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37 pages, 3496 KiB  
Review
The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review
by Md. Mominur Rahman, Md. Rezaul Islam, Sheikh Shohag, Md. Emon Hossain, Md. Saidur Rahaman, Fahadul Islam, Muniruddin Ahmed, Saikat Mitra, Mayeen Uddin Khandaker, Abubakr M. Idris, Kumarappan Chidambaram, Talha Bin Emran and Simona Cavalu
Molecules 2022, 27(5), 1713; https://doi.org/10.3390/molecules27051713 - 6 Mar 2022
Cited by 88 | Viewed by 10995
Abstract
Obesity and diabetes are the most demanding health problems today, and their prevalence, as well as comorbidities, is on the rise all over the world. As time goes on, both are becoming big issues that have a big impact on people’s lives. Diabetes [...] Read more.
Obesity and diabetes are the most demanding health problems today, and their prevalence, as well as comorbidities, is on the rise all over the world. As time goes on, both are becoming big issues that have a big impact on people’s lives. Diabetes is a metabolic and endocrine illness set apart by hyperglycemia and glucose narrow-mindedness because of insulin opposition. Heftiness is a typical, complex, and developing overall wellbeing worry that has for quite some time been connected to significant medical issues in individuals, all things considered. Because of the wide variety and low adverse effects, herbal products are an important hotspot for drug development. Synthetic compounds are not structurally diverse and lack drug-likeness properties. Thus, it is basic to keep on exploring herbal products as possible wellsprings of novel drugs. We conducted this review of the literature by searching Scopus, Science Direct, Elsevier, PubMed, and Web of Science databases. From 1990 until October 2021, research reports, review articles, and original research articles in English are presented. It provides top to bottom data and an examination of plant-inferred compounds that might be utilized against heftiness or potentially hostile to diabetes treatments. Our expanded comprehension of the systems of activity of phytogenic compounds, as an extra examination, could prompt the advancement of remedial methodologies for metabolic diseases. In clinical trials, a huge number of these food kinds or restorative plants, as well as their bioactive compounds, have been shown to be beneficial in the treatment of obesity. Full article
(This article belongs to the Special Issue Natural Compounds: An Antidiabetic and Anticancer Agents)
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