A New Diagnosis Tool of Cancer by Spectroscopic Analysis

Dear Colleagues,

Diagnosis of human cancer by pathologists has been based on the hematoxylin eosin (HE) stain for the last 140 years. Recently, however, many new kinds of spectroscopic analysis have suddenly been developed, especially in the field of the infrared region with laser and algorithm data analysis technologies, similar to a type of nuclear magnetic resonance imaging (MRI).

Spectroscopic analysis technology does not involve stain treatment of the slice of cancer tissue, especially, raw tissue by Raman, Fourier transform infrared (FT-IR), and mass spectroscopic microscopes. In the raw tissue sample, there is no artificial image information which misses the lipid, the protein secondary conformation, and the water molecule one in cancerous, dying HE, as in MRI.

This issue will be able to identify the dependent spectroscopic parameters on cancer stages, malignancies, and to answer how to correspond to the many kinds of differentiations of the morphological parameters for each cancer case in the future with the help of analysis techniques of an algorithm, chemometric analysis, and a fractal theory to solve image correlation and/or similarity of HE stain.

Prof. Dr. Norio Miyoshi
Guest Editor

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