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Analytical Method and Approach for Characterization of the Human Exposome Fraction Containing Environmental Toxicants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 3114

Special Issue Editors


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Guest Editor
Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Interests: bioanalytical chemistry; toxicology; bioanalytical method development and validation; analytical methods in metabolomics; measurements of biomarkers of exposure and effect; biomarker research

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Guest Editor
Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Interests: environmental analytical chemistry; environmental exposure; environmental health; emerging pollutants; biomarkers

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Guest Editor
Faculty of Public Health, Chaing Mai University, Chaing Mai 23000, Thailand
Interests: bioanalytical method development and validation; analytical methods in metabolomics; biomarker research; environmental health

Special Issue Information

Dear Colleagues,

The primary scope of this Special Issue is to publish a series of scientific articles that describe either a practical approach or analytical method for characterizing the human exposome carrying environmental toxicants. Environmental toxicants include, but are not limited to, polycyclic aromatic hydrocarbons, flame retardants, pesticides, plasticizers, heavy metals, chemicals generated from tobacco/cannabis smoke, and per- and polyfluoroalkyl substances. Emerging environmental contaminants to which humans may be exposed and which may contribute to health outcomes are also considered. For an article to be considered for publication, it must demonstrate the ability to measure more than one class of environmentally toxic chemicals or chemicals of concern in relevant matrices (water, dust, soil, urine, blood, etc.) that permit characterization of the human exposome. Any articles describing an analytical approach to measure at least two types of biomarkers will also be considered. In addition, any article outlining analytical method development must propose a method that has been validated following an established protocol such as a method by the FDA, SWGTOX, or a combination of both. Some validating parameters may be excluded if they are deemed irrelevant.

Dr. Parinya Panuwet
Dr. Amina Salamova
Dr. Warangkana Naksen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human exposome
  • environmental toxicants
  • analytical methods
  • toxic compounds
  • emerging toxicants
  • environmental toxicology
  • exposure assessment
  • biomarkers of exposure
  • biomarkers of effect

Published Papers (1 paper)

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Research

16 pages, 3767 KiB  
Article
Analytical Method Development of Benzisothiazolinone, a Biocide, Using LC–MS/MS and a Pharmacokinetic Application in Rat Biological Matrices
by Seong Jun Jo, Zhouchi Huang, Chae Bin Lee, Soon Uk Chae, Soo Hyeon Bae and Soo Kyung Bae
Molecules 2023, 28(2), 845; https://doi.org/10.3390/molecules28020845 - 14 Jan 2023
Cited by 1 | Viewed by 2509
Abstract
Benzisothiazolinone (BIT), a biocide widely used as a preservative in household cleaning and personal care products, is cytotoxic to lung cells and a known skin allergen in humans, which highlights the importance of assessing its toxicity and pharmacokinetics. In this study, a simple, [...] Read more.
Benzisothiazolinone (BIT), a biocide widely used as a preservative in household cleaning and personal care products, is cytotoxic to lung cells and a known skin allergen in humans, which highlights the importance of assessing its toxicity and pharmacokinetics. In this study, a simple, sensitive, and accurate LC–MS/MS method for the quantification of BIT in rat plasma, urine, or tissue homogenates (50 μL) using phenacetin as an internal standard was developed and validated. Samples were extracted with ethyl acetate and separated using a Kinetex phenyl–hexyl column (100 × 2.1 mm, 2.6 μm) with isocratic 0.1% formic acid in methanol and distilled water over a run time of 6 min. Positive electrospray ionization with multiple reaction monitoring transitions of m/z 152.2 > 134.1 for BIT and 180.2 > 110.1 for phenacetin was used for quantification. This assay achieved good linearity in the calibration ranges of 2–2000 ng/mL (plasma and urine) and 10–1000 ng/mL (tissue homogenates), with r ≥ 0.9929. All validation parameters met the acceptance criteria. BIT pharmacokinetics was evaluated via an intravenous and dermal application. This is the first study that evaluated BIT pharmacokinetics in rats, providing insights into the relationship between BIT exposure and toxicity and a basis for future risk assessment studies in humans. Full article
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