Nucleosides, Nucleotides, and Their Derivatives, Analogs, and Oligomers
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 3475
Special Issue Editor
Interests: nucleosides; nucleotides; oligonucleotide synthesis; chemical RNA synthesis; protecting groups; silyl protecting groups; combinatorial chemistry; epigenetic drugs; induced pluripotent stem cells (i-PSC); anticancer compounds
Special Issue Information
Dear Colleagues,
Nucleosides and nucleotides have drawn the attention of scientists for almost two centuries. The inosine nucleotide might be seen as a spectacular example of "scientific longevity" of this class of compounds, sparking the interest of researchers since its first isolation by Justus Liebig in 1847 (doi:10.1002/jlac.18470620302), with one of the latest reports (26 December 2018; doi:10.1073/pnas.1814367115) suggesting its primordial function in the development of the “RNA world”.
Nucleosides and nucleotides as components of native nucleic acids are the building blocks of chemically derived nucleic acids fragments, and form the basis of molecular tools of contemporary biology, xenobiology, and medicine, just to mention but a few, such as cloning, DNA/RNA sequencing, and diagnostics. Their use as antiviral and anticancer drugs, and nucleoside antibiotics, as well as their applications in nanotechnology, and their use in new materials development touches on some other areas of their important and perspective applications. The tremendous progress in understanding the live processes that have been achieved so far would not take place without studies on this group of molecules. This Special Issue aims to provide a forum for the dissemination of the latest information on the synthesis, isolation, properties, and applications of new nucleosides and nucleotides, as well as their analogs, oligomers, conjugates, materials, and drugs based-on, and so on.
Prof. Wojciech T. Markiewicz
Guest Editor
Manuscript Submission Information
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Keywords
- nucleoside
- nucleotide
- nucleoside analog
- nucleotide analog
- synthesis
- structure
- biological activity
- oligomers
- protecting group
- xenobiology
- anticancer drug
- antiviral nucleoside derivative
- anticancer nucleoside analog
- nucleoside antibiotics
- epigenetic nucleoderived drugs
- nanomaterial
