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Molecules
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Omics Analysis in Veterinary Medicine and Animal Science
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Omics Analysis in Veterinary Medicine and Animal Science

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 6425

Special Issue Editors

Prof. Dr. Gabriella Tedeschi

E-Mail Website
Guest Editor
Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy
Interests: omics; proteomics; peptidomics; biochemistry; enzymology; veterinary medicine; animal science
Dr. Elisa Maffioli

E-Mail Website
Guest Editor
Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy
Interests: omics; proteomics; peptidomics; biochemistry; enzymology; veterinary medicine; animal science

Special Issue Information

Dear Colleagues,

Omics methodologies (genomics, transcriptomics, metabolomics, and proteomics) have become important tools in veterinary medicine and animal sciences. These experimental approaches have the potential to lead to new basic and applied understandings of biological processes in animals to improve animal health, welfare and the quality of food animal products either directly or by generating new hypotheses and ideas for hypothesis-driven research. Genomics, for instance, has revolutionized how we make genetic associations with phenotypes of interest, from production traits to animal health, host–pathogen interactions and disease resistance, while proteomics in veterinary and animal science is an evolving field which holds a great promise not only for fundamental and applied discoveries regarding the biology and pathology of animals, with particular emphasis on (but not limited to) domestic species, but also in all aspects related to zoonoses, with an ever growing impact on human health. Furthermore, the application of omics approaches is an indispensable tool to tackle topics related to biodiversity and environmental pollution and sustainability.

The goal of this Special Issue is to present recent developments and applications of the various omics approaches to the ever-growing scientific community involved in research concerning animal science, health and welfare, and their impact on human health.

Prof. Dr. Gabriella Tedeschi
Dr. Elisa Maffioli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genomics
  • proteomics
  • transcriptomics
  • metabolomics
  • animal welfare
  • food quality and production
  • biomarkers
  • zoonoses
  • biodiversity
  • environmental pollution

Published Papers (2 papers)

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Research

18 pages, 729 KiB  
Article
Low n-6/n-3 Gestation and Lactation Diets Influence Early Performance, Muscle and Adipose Polyunsaturated Fatty Acid Content and Deposition, and Relative Abundance of Proteins in Suckling Piglets
by Yron Joseph Yabut Manaig, Silvia Sandrini, Sara Panseri, Gabriella Tedeschi, Josep M. Folch, Armand Sánchez, Giovanni Savoini and Alessandro Agazzi
Molecules 2022, 27(9), 2925; https://doi.org/10.3390/molecules27092925 - 4 May 2022
Cited by 5 | Viewed by 2745
Abstract
Elevated omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) ratios in swine diets can potentially impose a higher risk of inflammatory and metabolic diseases in swine. A low ratio between the two omega PUFAs has beneficial effects on sows’ and piglets’ production [...] Read more.
Elevated omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) ratios in swine diets can potentially impose a higher risk of inflammatory and metabolic diseases in swine. A low ratio between the two omega PUFAs has beneficial effects on sows’ and piglets’ production performance and immunity status. At present, there are few studies on how sow nutrition directly affects the protein and fat deposition in suckling piglets. Two groups of sows were fed diets with high or low n-6/n-3 polyunsaturated ratios of 13:1 (SOY) and 4:1 (LIN), respectively, during gestation and lactation. Longissimus dorsi muscle and adipose tissue from newborn piglets, nourished only with sow’s milk, were subjected to fatty acid profiling by gas chromatography–mass spectrometry (GC-MS) and to proteomics assays based on nano-liquid chromatography coupled to high-resolution tandem mass spectrometry (nLC-HRMS). Fatty acid profiles on both muscle and adipose tissues resembled the magnitude of the differences between fatty acid across diets. Proteomic analysis revealed overabundance of 4 muscle and 11 adipose tissue proteins in SOY compared to LIN in both piglet tissues. The detected overabundance of haptoglobin, an acute-phase protein, and the stimulation of protein-coding genes and proteins related to the innate immune response and acute inflammatory response could be associated with the pro-inflammatory role of n-6 PUFAs. Full article
(This article belongs to the Special Issue Omics Analysis in Veterinary Medicine and Animal Science)
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11 pages, 1573 KiB  
Article
The Influence of Bacteria Causing Subclinical Mastitis on the Structure of the Cow’s Milk Microbiome
by Łukasz Kaczorowski, Jolanta Powierska-Czarny, Łukasz Wolko, Agnieszka Piotrowska-Cyplik, Paweł Cyplik and Jakub Czarny
Molecules 2022, 27(6), 1829; https://doi.org/10.3390/molecules27061829 - 11 Mar 2022
Cited by 20 | Viewed by 2930
Abstract
Mastitis is the most expensive disease of dairy cattle across the world and is the main reason for the use of antibiotics in animal husbandry. The aim of this study was to analyze the microbiome of raw milk obtained from a semi-subsistence farm [...] Read more.
Mastitis is the most expensive disease of dairy cattle across the world and is the main reason for the use of antibiotics in animal husbandry. The aim of this study was to analyze the microbiome of raw milk obtained from a semi-subsistence farm located in the Kuyavian–Pomeranian Voivodeship in Poland. Milk from healthy cows and from cows with subclinical mastitis was analyzed. The following pathogenic bacteria were found in milk from individuals with subclinical mastitis: Escherichia coli or Streptococcus agalactiae. The composition of drinking milk was assessed on the basis of 16S rRNA gene sequencing using the Ion Torrent platform. Based on the conducted research, significant changes in the composition of the milk microbiome were found depending on the physiological state of the cows. The microbiome of milk from healthy cows differed significantly from the milk from cows with subclinical mastitis. Two phyla dominated in the milk from healthy cows: Firmicutes and Proteobacteria, in equal amounts. On the contrary, in the milk from cows with diagnosed subclinical mastitis, one of the types dominated: either Firmicutes or Proteobacteria, and was largely predominant. Moreover, the milk microflora from the ill animals were characterized by lower values of the determined biodiversity indicators than the milk from healthy cows. The presence of pathogenic bacteria in the milk resulted in a significant reduction in the share of lactic acid bacteria in the structure of the population of microorganisms, which are of great importance in the production technology of regional products. Full article
(This article belongs to the Special Issue Omics Analysis in Veterinary Medicine and Animal Science)
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