Small Molecules: A Field of Opportunities for Differential Diagnosis and Precision Medicine
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 11748
Special Issue Editors
Interests: adductomics; drug metabolism; mass spectrometry; protein covalent adducts; biomarkers of exposure; diagnosis biomarkers; molecular mechanisms of chemically-induced adverse reactions; bioactivation mechanisms
Special Issues, Collections and Topics in MDPI journals
Interests: pharmacology; toxicology; drug metabolism; pharmacokinetics; personalized medicine; toxicokinetics; iatrogenic effects of drug; chronic toxicity; models on toxicity; translational pharmacology; therapeutic drug monitoring
Special Issue Information
Dear Colleagues,
Non-communicable diseases (NCDs) are the result of a combination of genetic, physiological, environmental, and behavioral factors. While NCDs are often associated with aging, each year, 15 million people die prematurely due to NCDs. Early detection along with timely and personalized treatment are critical for improving the management of these diseases.
The small-molecule profile is closely linked to phenotype and reflects not only the dysregulation of metabolic networks but also the individual ability to respond to these stimuli. Therefore, assessment of the endogenous exposure to small molecules (metabolites and peptides) constitutes a huge opportunity for achieving earlier diagnosis of NCDs and, thereby, the application of preventive, rather than reactive, clinical strategies. In addition, it offers the possibility for differential diagnosis—distinguishing different molecular phenotypes in a particular NCD or between distinct NCDs that share clinical features. This will be key for the establishment of personalized therapies and, hence, better management of NCDs.
This Special Issue includes original research and review articles on topics ranging from the development of new analytical methodologies as well as targeted and untargeted metabolomics and peptidomics works providing the identification of individual or combinations of small molecules that can be used for the differential diagnosis of diseases and, in particular, of NCDs.
Dr. Alexandra Antunes
Dr. Sofia Azeredo Pereira
Dr. Judit Morello
Guest Editors
Manuscript Submission Information
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Keywords
- non-communicable diseases
- metabolites
- metabolomics
- peptidomics
- xenobiotics
- biomarker discovery
- differential diagnosis
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