Applications of Calcium Phosphate-Based Nanostructured Materials and Coatings: 2nd Edition

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Inorganic Materials and Metal-Organic Frameworks".

Deadline for manuscript submissions: 13 June 2025 | Viewed by 1664

Special Issue Editors


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Guest Editor
Department of Chemistry “Giacomo Ciamician”, University of Bologna, Via F. Selmi 2, I-40126 Bologna, Italy
Interests: biomaterials; biomimetic materials chemistry; bioceramics; nanocrystals; hydroxyapatite; octacalcium phosphate; metal nanoparticles; bioactive coatings
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Guest Editor
Dipartimento di Chimica, Materiali ed Ingegneria Chimica "Giulio Natta", Politecnico di Milano, Via Luigi Mancinelli, 7, 20131 Milan, Italy
Interests: calcium phosphates; nanostructured coatings; biomaterials; infection; 3D printing and bioprinting; orthopaedics; orthopaedic oncology; tissue models; cultural heritage; stone consolidants
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Special Issue Information

Dear Colleagues,

Calcium phosphates have been widely studied in recent decades because they have peculiar properties that make them suitable for a variety of applications.

Calcium phosphate-based nanostructured materials have a significant relevance, and, in addition, they can be easily functionalized with ions, small molecules, polyelectrolytes, or drugs, which can significantly alter their physico-chemical, mechanical, and/or biological properties. Nanostructuration itself is also important, as it permits the regulation of the dissolution profile, microbial/cell adhesion, and (eventually) drug delivery profile.

The aim of this Special Issue is to document the current advances and future perspectives in the field of calcium phosphate-based nanostructured materials, as well as their fields of application.

The topics of interest include, but are not limited to, the following:

  • Calcium phosphates in biomedicine and cultural heritage conservation;
  • Synthesis or deposition of calcium phosphate nanostructured coatings and their applications;
  • Functionalized calcium phosphates;
  • Advanced characterization techniques to investigate the properties of nanostructured materials (composition, morphology, mechanical properties, solubility, crystallinity, ion release in different media, etc.).

Prof. Dr. Elisa Boanini
Dr. Gabriela Graziani
Guest Editors

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Keywords

  • calcium phosphates
  • nanostructure
  • coatings
  • biomedicine
  • morphologymechanical properties
  • solubility
  • crystallinity
  • ion release

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Published Papers (1 paper)

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Research

16 pages, 3490 KiB  
Article
Synthetic or Natural (Bio-Based) Hydroxyapatite? A Systematic Comparison between Biomimetic Nanostructured Coatings Produced by Ionized Jet Deposition
by Matteo Montesissa, Enrico Sassoni, Marco Boi, Giorgia Borciani, Elisa Boanini and Gabriela Graziani
Nanomaterials 2024, 14(16), 1332; https://doi.org/10.3390/nano14161332 - 9 Aug 2024
Viewed by 1245
Abstract
Calcium phosphate (CaP)-based materials are largely explored in orthopedics, to increase osseointegration of the prostheses and specifically in spine surgery, to permit better fusion. To address these aims, nanostructured biogenic apatite coatings are emerging, since they better mimic the characteristics of the host [...] Read more.
Calcium phosphate (CaP)-based materials are largely explored in orthopedics, to increase osseointegration of the prostheses and specifically in spine surgery, to permit better fusion. To address these aims, nanostructured biogenic apatite coatings are emerging, since they better mimic the characteristics of the host tissue, thus potentially being better candidates compared to their synthetic counterpart. Here, we compare hydroxyapatite (HA) nanostructured coatings, obtained by ionized jet deposition, starting from synthetic and natural sources. The starting materials and the corresponding films are characterized and compared from a compositional and morphological point of view, then their stability is studied after post-treatment annealing. Although all the films are formed by globular aggregates and show morphological features at different scales (from nano to micro), significant differences are found in composition between the synthetic and naturally derived HA in terms of magnesium and sodium content, carbonate substitution and Ca/P ratio, while differences between the coatings obtained by the different natural HA sources are minor. In addition, the shape of the aggregates is also target-dependent. All coatings have a good stability after over 14 days of immersion in medium, with natural apatite coatings showing a better behavior, as no cracking and detachments are observed during immersion. Based on these results, both synthetic and naturally derived apatitic materials appear promising for applications in spine surgery, with coatings from natural sources possessing physiochemical properties more similar to the mineral phase of the human bone tissue. Full article
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