Nanomaterials in Analytical Methods for Biomedical, Environmental, and Energy Applications

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2301

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Faculty of Medicine, Transilvania University of Brasov, 40268 Brasov, Romania
Interests: diagnostic and therapeutic biomarker investigation; laboratory medicine; novel clinical molecular diagnostic methods development
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Special Issue Information

Dear Colleagues,

Nanomaterials, with sizes typically ranging from 1 to 100 nanometers, exhibit exceptional properties due to their ultrafine nature. These materials can be tailored into various forms and possess distinct physical and chemical characteristics compared to their larger-scale counterparts. Functional nanostructured materials hold great promise for sustainable applications in a wide range of fields. For this Special Issue, "Nanomaterials in Analytical Methods for Biomedical, Environmental and Energy Applications" we invite manuscripts dealing with nanomaterials in the following topics:

  • developing new methods that lead to the identification and quantification of very small amounts of analyte, but also how to deal with complex matrices such as food, biological, or environmental samples;
  • tailoring functional nanostructured materials and molecular structures for analytical applications ranging from research to medical, food, and environmental monitoring in civil and military engineering, but also in energy engineering.
We encourage colleagues to share their scientific achievements in original research covering the development, evaluation, simulation, and use of various nanoplatforms, with promising applications in biomedical engineering, biopharmaceutical engineering, bioprocess engineering, synthetic biology, tissue engineering, regenerative medicine, environmental biotechnology, as well as food and agricultural engineering, civil and military engineering, but also the production, consumption, and storage of energy. The review articles should provide an up-to-date and state-of-the-art overview of the analytical methods for the areas covered. Please feel free to contact us and send us suggestions that you would like to discuss beforehand. We look forward to your contribution and welcome your participation in this Special Issue.

Dr. Monica Florescu
Guest Editor

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Keywords

  • nanoparticles
  • nanofibers
  • liposomes
  • functional nanostructured materials
  • biomedicine
  • environment
  • energy
  • sensors
  • biosensors
  • drug delivery systems
  • tissue engineering
  • regenerative medicine
  • controlled release

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Published Papers (2 papers)

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Research

16 pages, 3435 KiB  
Article
Harnessing a Safe Novel Lipid Nanoparticle: Targeted Oral Delivery to Colonic Epithelial and Macrophage Cells in a Colitis Mouse Model
by Rabeya Jafrin Mow, Michal Pawel Kuczma, Xiaodi Shi, Sridhar Mani, Didier Merlin and Chunhua Yang
Nanomaterials 2024, 14(22), 1800; https://doi.org/10.3390/nano14221800 - 9 Nov 2024
Viewed by 878
Abstract
A novel lipid nanoparticle (nLNP), formulated with three essential lipids to mimic ginger-derived exosomal particles, shows strong potential for delivering IL-22 mRNA specifically to the colon, presenting a unique oral drug delivery system for inflammatory bowel disease (IBD). However, its cellular targets and [...] Read more.
A novel lipid nanoparticle (nLNP), formulated with three essential lipids to mimic ginger-derived exosomal particles, shows strong potential for delivering IL-22 mRNA specifically to the colon, presenting a unique oral drug delivery system for inflammatory bowel disease (IBD). However, its cellular targets and uptake behavior in healthy versus diseased colons remain unclear. Understanding these aspects is crucial for fully elucidating its targeting effectiveness in inflamed colon tissue. This study investigates the nLNP’s cellular targets in healthy and diseased mouse colons. Flow cytometry compared nLNP uptake in healthy mice and a DSS-induced acute colitis model. The results revealed efficient internalization of nLNP by colonic epithelial cells in healthy and inflamed mice. In non-inflamed mice, the small number of colonic macrophages resulted in minimal uptake of nLNP by these cells. In inflamed mice, macrophages migrated to the damaged epithelium, where nLNP uptake was significantly increased, highlighting the nLNP’s ability to target both epithelial and macrophage cells during inflammation. Additionally, safety assessments showed that the nLNP neither altered in vitro kinase activities nor exhibited immunotoxicity or induced in vivo toxicity at the maximum tolerated oral dose. These findings underscore the nLNP’s safety and potential as a promising epithelial/macrophage-targeted drug delivery platform for oral ulcerative colitis (UC) treatment. Full article
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14 pages, 11375 KiB  
Article
Comparative Study of Cu Ion Adsorption by Nano-Hydroxyapatite Powder Synthesized from Chemical Reagents and Clam Shell-Derived Calcium Sources
by Shih-Ching Wu, Hsueh-Chuan Hsu, Hong-Yi Ji and Wen-Fu Ho
Nanomaterials 2024, 14(17), 1431; https://doi.org/10.3390/nano14171431 - 1 Sep 2024
Viewed by 914
Abstract
The increasing contamination of water sources by heavy metals necessitates the development of efficient and sustainable adsorption materials. This study evaluates the potential of nano-hydroxyapatite (HA) powders synthesized from chemical reagents (Chem-HA) and clam shells (Bio-HA) as adsorbents for Cu ions in aqueous [...] Read more.
The increasing contamination of water sources by heavy metals necessitates the development of efficient and sustainable adsorption materials. This study evaluates the potential of nano-hydroxyapatite (HA) powders synthesized from chemical reagents (Chem-HA) and clam shells (Bio-HA) as adsorbents for Cu ions in aqueous solutions. Both powders were synthesized using microwave irradiation at 700 W for 5 min, resulting in nano-sized rod-like particles confirmed as HA by X-ray diffraction (XRD). Bio-HA exhibited higher crystallinity (67.5%) compared to Chem-HA (34.9%), which contributed to Bio-HA’s superior adsorption performance. The maximum adsorption capacities were 436.8 mg/g for Bio-HA and 426.7 mg/g for Chem-HA, as determined by the Langmuir isotherm model. Kinetic studies showed that the Cu ion adsorption followed the pseudo-second-order model, with Bio-HA achieving equilibrium faster and displaying a higher rate constant (6.39 × 10⁻4 g/mg·min) than Chem-HA (5.16 × 10⁻4 g/mg·min). Thermodynamic analysis indicated that the adsorption process was spontaneous and endothermic, with Bio-HA requiring less energy (ΔH° = 39.00 kJ/mol) compared to Chem-HA (ΔH° = 43.77 kJ/mol). Additionally, the activation energy for Bio-HA was lower (41.62 kJ/mol) than that for Chem-HA (46.39 kJ/mol), suggesting better energy efficiency. The formation of a new Cu2(OH)PO4 phase after adsorption, as evidenced by XRD, confirmed that the Cu ions replaced the Ca ions in the HA lattice. These findings demonstrate that Bio-HA, derived from natural sources, offers environmental benefits as a recyclable material, enhancing heavy metal removal efficiency while contributing to sustainability by utilizing waste materials and reducing an environmental impact. Full article
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