Toxicity Evaluation of Nanoparticles: 2nd Edition

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Environmental Nanoscience and Nanotechnology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 808

Special Issue Editors


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Guest Editor
Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China
Interests: nanomaterials; nanotoxicity; fluorescence imaging; environmental microbiology; cell toxicology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Institute of Environmental Research at Greater Bay, Ministry of Education, Guangzhou University, Guangzhou 510006, China
Interests: nanomedicine; nanotoxicology; environmental safety; environmental toxicology; theranostics; imaging; nanoparticle library; nanoparticle modification; surface modification; chemical biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increasing production and application of nanomaterials causes them to release into the environment, with adverse impacts on ecosystems and human health. Such toxicities must be reliably assessed, the mechanisms must be elucidated, and the risk should be predicted. Therefore, it is essential to develop powerful methods to evaluate nanotoxicity, such as in vitro methods (e.g., cell-based or cell-free testing), animals tests (e.g., zebra fish), and computational modeling. Given this background, this Special Issue will assemble high-quality original research and review papers, highlighting nanotoxicity investigations using various biological models and in-depth mechanism investigations. This Special Issue will also focus on the application of advanced machine learning, deep learning algorithms in nanotoxicity modeling and prediction, and molecular simulation to elucidate the mechanisms of emerging nanomaterials.

Dr. Rongrong Liu
Prof. Dr. Bing Yan
Guest Editors

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Keywords

  • nanomaterials
  • nanomedicine
  • nanotoxicity
  • nanoparticle modification
  • mechanistic toxicity
  • environmental pollution
  • environmental toxicology
  • nano chemistry
  • cell toxicology
  • molecular toxicology
  • nano functionalization

Published Papers (1 paper)

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Research

13 pages, 2634 KiB  
Article
Effects of Multiple Stressors, Pristine or Sulfidized Silver Nanomaterials, and a Pathogen on a Model Soil Nematode Caenorhabditis elegans
by Jarad P. Cochran, Phocheng Ngy, Jason M. Unrine, Christopher J. Matocha and Olga V. Tsyusko
Nanomaterials 2024, 14(11), 913; https://doi.org/10.3390/nano14110913 - 23 May 2024
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Abstract
Previous research using the model soil nematode Caenorhabditis elegans has revealed that silver nanoparticles (AgNP) and their transformed counterpart, sulfidized AgNP (sAgNP), reduce their reproduction and survival. To expand our understanding of the environmental consequences of released NP, we examined the synergistic/antagonistic effects [...] Read more.
Previous research using the model soil nematode Caenorhabditis elegans has revealed that silver nanoparticles (AgNP) and their transformed counterpart, sulfidized AgNP (sAgNP), reduce their reproduction and survival. To expand our understanding of the environmental consequences of released NP, we examined the synergistic/antagonistic effects of AgNP and sAgNP along with AgNO3 (ionic control) on C. elegans infected with the pathogen Klebsiella pneumoniae. Individual exposures to each stressor significantly decreased nematode reproduction compared to controls. Combined exposures to equitoxic EC30 concentrations of two stressors, Ag in nanoparticulate (AgNP or sAgNP) or ionic form and the pathogen K. pneumoniae, showed a decline in the reproduction that was not significantly different compared to individual exposures of each of the stressors. The lack of enhanced toxicity after simultaneous combined exposure is partially due to Ag decreasing K. pneumoniae pathogenicity by inhibiting biofilm production outside the nematode and significantly reducing viable pathogens inside the host. Taken together, our results indicate that by hindering the ability of K. pneumoniae to colonize the nematode’s intestine, Ag reduces K. pneumoniae pathogenicity regardless of Ag form. These results differ from our previous research where simultaneous exposure to zinc oxide (ZnO) NP and K. pneumoniae led to a reproduction level that was not significantly different from the controls. Full article
(This article belongs to the Special Issue Toxicity Evaluation of Nanoparticles: 2nd Edition)
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