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Nanomaterials
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Plasmonic and Magnetic Nanoparticles for Localized-Hyperthermia
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Plasmonic and Magnetic Nanoparticles for Localized-Hyperthermia

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 16209

Special Issue Editor

Dr. Lenaic Lartigue

E-Mail Website
Guest Editor
CNRS, CEISAM UMR 6230, Université de Nantes, F-44000 Nantes, France
Interests: magnetic nanoparticles; nanomagnetism; nano-assemblies; magnetic fluid hyperthermia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hyperthermia is a medical procedure that has been used since the end of the 19th century for the treatment of solid tumors. It consists of heating cancer cells, which are more sensitive to temperature than healthy cells, to around 42 - 45°C. Since the 1980s, the combination of nanoparticles and external physical stimuli has made it possible to limit hyperthermia to the tumor area. This is called localized hyperthermia. Depending on the nature of the nanoparticles and the external physical stimulus, two types of localized hyperthermia treatments can be distinguished: (i) photothermal therapy, PTT, assisted by plasmonic nanoparticles (mainly gold) under near-infrared illumination, NIR, (in the 650-900 nm range); (ii) magnetic fluid hyperthermia (MFH) mediated by superparamagnetic nanoparticles (mainly iron oxides or ferrites) under alternating magnetic fields (AMFs). In both cases, the parameters that influence the photo or magneto-thermal response of the nanoparticles are size, shape or self-assembly. For gold nanoparticles, nanorods, nanostars or nanoshells are the shapes that have the best heating properties. For iron oxide nanoparticles, the three most promising systems are nanocubes, ferrite core–shell nanosystems and self-assemblies.

This Special Issue of Nanomaterials, entitled “Plasmonic and Magnetic Nanoparticles for Localized-Hyperthermia”, aims to highlight magnetic and plasmonic nanomaterials that allow heating properties to be increased in solution, in cellulo and in vivo. The study and understanding of synergistic effects in systems that combine magnetic and plasmonic nanoparticles will also be considered.

Dr. Lenaic Lartigue
Guest Editor

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Keywords

  • magnetic fluid hyperthermia
  • photothermal therapy
  • magnetic nanocube
  • magnetic multicore nanoparticules
  • gold nanoshell
  • core–shell ferrite
  • gold nanorods
  • gold nanostar

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Published Papers (5 papers)

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Research

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22 pages, 10663 KiB  
Article
Optimization of Magnetic Cobalt Ferrite Nanoparticles for Magnetic Heating Applications in Biomedical Technology
by Diana Zahn, Joachim Landers, Marco Diegel, Soma Salamon, Andreas Stihl, Felix H. Schacher, Heiko Wende, Jan Dellith and Silvio Dutz
Nanomaterials 2023, 13(10), 1673; https://doi.org/10.3390/nano13101673 - 18 May 2023
Cited by 6 | Viewed by 2114
Abstract
Using magnetic nanoparticles for extracorporeal magnetic heating applications in bio-medical technology allows higher external field amplitudes and thereby the utilization of particles with higher coercivities (HC). In this study, we report the synthesis and characterization of high coercivity cobalt ferrite nanoparticles [...] Read more.
Using magnetic nanoparticles for extracorporeal magnetic heating applications in bio-medical technology allows higher external field amplitudes and thereby the utilization of particles with higher coercivities (HC). In this study, we report the synthesis and characterization of high coercivity cobalt ferrite nanoparticles following a wet co-precipitation method. Particles are characterized with magnetometry, X-ray diffraction, Mössbauer spectroscopy, transmission electron microscopy (TEM) and calorimetric measurements for the determination of their specific absorption rate (SAR). In the first series, CoxFe3−xO4 particles were synthesized with x = 1 and a structured variation of synthesis conditions, including those of the used atmosphere (O2 or N2). In the second series, particles with x = 0 to 1 were synthesized to study the influence of the cobalt fraction on the resulting magnetic and structural properties. Crystallite sizes of the resulting particles ranged between 10 and 18 nm, while maximum coercivities at room temperatures of 60 kA/m for synthesis with O2 and 37 kA/m for N2 were reached. Magnetization values at room temperature and 2 T (MRT,2T) up to 60 Am2/kg under N2 for x = 1 can be achieved. Synthesis parameters that lead to the formation of an additional phase when they exceed specific thresholds have been identified. Based on XRD findings, the direct correlation between high-field magnetization, the fraction of this antiferromagnetic byphase and the estimated transition temperature of this byphase, extracted from the Mössbauer spectroscopy series, we were able to attribute this contribution to akageneite. When varying the cobalt fraction x, a non-monotonous correlation of HC and x was found, with a linear increase of HC up to x = 0.8 and a decrease for x > 0.8, while magnetometry and in-field Mössbauer experiments demonstrated a moderate degree of spin canting for all x, yielding high magnetization. SAR values up to 480 W/g (@290 kHz, 69 mT) were measured for immobilized particles with x = 0.3, whit the external field amplitude being the limiting factor due to the high coercivities of our particles. Full article
(This article belongs to the Special Issue Plasmonic and Magnetic Nanoparticles for Localized-Hyperthermia)
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13 pages, 3800 KiB  
Article
Visible Laser Light Mediated Cancer Therapy via Photothermal Effect of Tannin-Stabilized Magnetic Iron Oxide Nanoparticles
by Nikesh Gupta, Chetna Gupta and Himadri B. Bohidar
Nanomaterials 2023, 13(9), 1456; https://doi.org/10.3390/nano13091456 - 25 Apr 2023
Cited by 8 | Viewed by 2092
Abstract
Super-paramagnetic iron oxide nanoparticles (SPIONs/Fe3O4) were synthesized in aqueous medium under a nitrogen atmosphere. These particles were made water-dispersible by cladding them with tannic acid (TA). The synthesized nanoparticles were characterized for their size and surface charge using HRTEM [...] Read more.
Super-paramagnetic iron oxide nanoparticles (SPIONs/Fe3O4) were synthesized in aqueous medium under a nitrogen atmosphere. These particles were made water-dispersible by cladding them with tannic acid (TA). The synthesized nanoparticles were characterized for their size and surface charge using HRTEM and zetasizer. It was found that the size of the particles formed was around 15 nm with almost spherical morphology and negative surface charge. Vibrating sample magnetometer (VSM) data attributed a super-paramagnetic nature to these nanoparticles. The photo-thermal dynamics of these magnetite (Fe3O4) nanoparticles was characterized by exciting their dispersions with laser radiation in the visible region (635 nm). Remarkably, 17 min of laser irradiation of the dispersion raised its temperature by ~25 °C (25 to 49.8 °C), whereas for the solvent, it was limited to not more than 4 °C (after 60 min). Thus, the Fe3O4 nanoparticles generated localized hyperthermia for potential use in cancer therapy of tumor management. The photo-thermal dynamics of these nanoparticles was investigated in-vitro for cancer therapy, and it was clearly shown that cancer cell growth was inhibited, and considerable cellular damage occurred when cells were incubated with laser-activated magnetic nanoparticles. No noticeable innate toxicity of the nanoparticles was observed on cancer cell lines. The effectiveness of these nanoparticles was studied on several malignant cell lines, and an acceptable Fe3O4 concentration range was subsequently determined for generating substantial cell death by hyperthermia, but not inherent toxicity. Therefore, we concluded that this nano-system is effective and less time consuming for the treatment of malignant diseases such as cancer. Full article
(This article belongs to the Special Issue Plasmonic and Magnetic Nanoparticles for Localized-Hyperthermia)
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18 pages, 7658 KiB  
Article
Preparation of Functional Nanoparticles-Loaded Magnetic Carbon Nanohorn Nanocomposites towards Composite Treatment
by Fitriani Jati Rahmania, Yi-Shou Huang, Yitayal Admassu Workie, Toyoko Imae, Anna Kondo, Yukiko Miki, Ritsuko Imai, Takashi Nagai, Hiroshi Nakagawa, Noriyasu Kawai and Kaname Tsutsumiuchi
Nanomaterials 2023, 13(5), 839; https://doi.org/10.3390/nano13050839 - 23 Feb 2023
Cited by 3 | Viewed by 2451
Abstract
Combination therapy for cancer is expected for the synergetic effect of different treatments, and the development of promising carrier materials is demanded for new therapeutics. In this study, nanocomposites including functional nanoparticles (NPs) such as samarium oxide NP for radiotherapy and gadolinium oxide [...] Read more.
Combination therapy for cancer is expected for the synergetic effect of different treatments, and the development of promising carrier materials is demanded for new therapeutics. In this study, nanocomposites including functional nanoparticles (NPs) such as samarium oxide NP for radiotherapy and gadolinium oxide NP as a magnetic resonance imaging agent were synthesized and chemically combined with iron oxide NP-embedded or carbon dot-coating iron oxide NP-embedded carbon nanohorn carriers, where iron oxide NP is a hyperthermia reagent and carbon dot exerts effects on photodynamic/photothermal treatments. These nanocomposites exerted potential for delivery of anticancer drugs (doxorubicin, gemcitabine, and camptothecin) even after being coated with poly(ethylene glycol). The co-delivery of these anticancer drugs played better drug-release efficacy than the independent drug delivery, and the thermal and photothermal procedures enlarged the drug release. Thus, the prepared nanocomposites can be expected as materials to develop advanced medication for combination treatment. Full article
(This article belongs to the Special Issue Plasmonic and Magnetic Nanoparticles for Localized-Hyperthermia)
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16 pages, 3482 KiB  
Article
Designing Highly Efficient Temperature Controller for Nanoparticles Hyperthermia
by Adeel Bashir, Sikandar Khan, Salem Bashmal, Naveed Iqbal, Sami Ullah and Liaqat Ali
Nanomaterials 2022, 12(19), 3539; https://doi.org/10.3390/nano12193539 - 10 Oct 2022
Viewed by 2218
Abstract
This paper presents various control system design techniques for temperature control of Magnetic Fluid hyperthermia. The purpose of this research is to design a cost-effective, efficient, and practically implementable temperature controller for Magnetic Fluid hyperthermia, which is presently under research as a substitute [...] Read more.
This paper presents various control system design techniques for temperature control of Magnetic Fluid hyperthermia. The purpose of this research is to design a cost-effective, efficient, and practically implementable temperature controller for Magnetic Fluid hyperthermia, which is presently under research as a substitute to the radiation and chemotherapy treatment of cancer. The principle of this phenomenon centers on the greater sensitivity of tumor cells to changes in temperature in comparison to healthy cells. Once the nanoparticles reach the desired tissue, it can then be placed in a varying magnetic field to dissipate the heat locally by raising the temperature to 45 °C in order to kill cancerous cells. One of the challenging tasks is to maintain the temperature strictly at desired point i.e., 45 °C. Temperature controller for magnetic fluid hyperthermia provides the tight control of temperature in order to avoid folding of proteins and save the tissues around the cancerous tissue from getting destroyed. In contrast with most of the existing research on this topic, which are based on linear control strategies or their improved versions, the novelty of this research lies in applying nonlinear control technique like Sliding Mode Control (SMC) to accurately control the temperature at desired value. A comparison of the control techniques is presented in this paper, based on reliability, robustness, precision and the ability of the controller to handle the non-linearities that are faced during the treatment of cancer. SMC showed promising results in terms of settling time and rise time. Steady state error was also reduced to zero using this technique. Full article
(This article belongs to the Special Issue Plasmonic and Magnetic Nanoparticles for Localized-Hyperthermia)
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Review

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40 pages, 6170 KiB  
Review
Iron Oxide@Mesoporous Silica Core-Shell Nanoparticles as Multimodal Platforms for Magnetic Resonance Imaging, Magnetic Hyperthermia, Near-Infrared Light Photothermia, and Drug Delivery
by Alexandre Adam and Damien Mertz
Nanomaterials 2023, 13(8), 1342; https://doi.org/10.3390/nano13081342 - 12 Apr 2023
Cited by 29 | Viewed by 6552
Abstract
The design of core-shell nanocomposites composed of an iron oxide core and a silica shell offers promising applications in the nanomedicine field, especially for developing efficient theranostic systems which may be useful for cancer treatments. This review article addresses the different ways to [...] Read more.
The design of core-shell nanocomposites composed of an iron oxide core and a silica shell offers promising applications in the nanomedicine field, especially for developing efficient theranostic systems which may be useful for cancer treatments. This review article addresses the different ways to build iron oxide@silica core-shell nanoparticles and it reviews their properties and developments for hyperthermia therapies (magnetically or light-induced), combined with drug delivery and MRI imaging. It also highlights the various challenges encountered, such as the issues associated with in vivo injection in terms of NP–cell interactions or the control of the heat dissipation from the core of the NP to the external environment at the macro or nanoscale. Full article
(This article belongs to the Special Issue Plasmonic and Magnetic Nanoparticles for Localized-Hyperthermia)
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