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Nanomaterials
Special Issues
Synthesis and Applications of Nanomaterial-Based Probes for Bio-Imaging
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Synthesis and Applications of Nanomaterial-Based Probes for Bio-Imaging

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 13385

Special Issue Editors

Prof. Dr. Takashi Jin

E-Mail Website
Guest Editor
1. Riken Center for Biosystems Dynamics Research, Suita, Japan
2. Graduate School of Frontier Biosciences, Osaka University, Yamada-oka 2-1, Suita, Osaka 565-0871, Japan
Interests: molecular imaging; imaging probes; molecular dynamics in vivo; targeted drug delivery; early detection of cancer; biomedical applications
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Horacio Cabral

E-Mail Website
Guest Editor
Department of Bioengineering, The University of Tokyo, Tokyo, Japan
Interests: nanomedicine; mRNA delivery; immunotherapy; cancer; in vivo imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterial-based probes have greatly contributed to bio-imaging in basic life science and clinical research. Bio-imaging is crucial to see what is happening inside the cell and body at the molecular level, leading to an indispensable modality in life sciences and medical sciences. Bio-imaging uses a variety of imaging techniques, such as magnetic resonance (MR), positron emission tomography (PET), ultrasonic imaging, and optical (fluorescence/bioluminescence/Raman), which employ imaging probes to target and detect molecular and cellular dynamics in a living system. In the clinical field, nanomaterial-based bio-imaging plays a crucial role in cancer diagnosis and treatment. To date, bio-imaging has been improved not only by the development of imaging probes, but also by the development of imaging techniques. This Special Issue focusses on recent advances and future prospects in the area of bio-imaging probes and their synthetic techniques. This Issue will contain research communications, papers, and reviews in chemical, biological, and biomedical studies, regarding the synthesis and application of nanomaterial-based probes for bio-imaging.

Prof. Dr. Takashi Jin
Prof. Dr. Horacio Cabral
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • CT/MRI/PET/ultrasonic probes
  • Optical (fluorescence/bioluminescence/Raman) probes
  • Super-resolution imaging probes
  • Cellular imaging probes
  • Deep-tissue (NIR) imaging probes
  • Multimodal probes
  • Microenvironment-sensitive probes
  • Tumor detection/therapy probes

Published Papers (4 papers)

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Research

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10 pages, 18137 KiB  
Article
Multi-Scale Photoacoustic Assessment of Wound Healing Using Chitosan–Graphene Oxide Hemostatic Sponge
by Xiangwei Lin, Yajing Shen and Lidai Wang
Nanomaterials 2021, 11(11), 2879; https://doi.org/10.3390/nano11112879 - 28 Oct 2021
Cited by 11 | Viewed by 2046
Abstract
Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development of chitosan–graphene oxide-based hemostatic composite and multi-scale [...] Read more.
Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development of chitosan–graphene oxide-based hemostatic composite and multi-scale photoacoustic evaluation of the hemostatic performance. The hemostatic sponge can quickly and efficiently absorb the blood with its porous cavity and specific surficial property. We inspect the hemostatic performance via an in vitro blood absorption test and in vivo mouse bleeding injury experiments. Results show that the synthesized hemostatic sponge can not only absorb plasma in blood fast with its interior porous structure but also stimulate the interfacial reaction with erythrocytes and platelets. The superiority of multi-scale photoacoustic imaging for guiding, monitoring, and evaluating the hemostatic stages of sponges is demonstrated with high spatial resolution and great sensitivity at depths. Photoacoustic evaluation of a chitosan–graphene oxide-based hemostatic sponge has the potential to be transferred toward the clinical assessment of wound healing. Full article
(This article belongs to the Special Issue Synthesis and Applications of Nanomaterial-Based Probes for Bio-Imaging)
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12 pages, 2532 KiB  
Article
Dichroic Circular Polarizers Based on Plasmonics for Polarization Imaging Applications
by Junyan Zheng, Xin He, Paul Beckett, Xinjie Sun, Zixin Cai, Wenyi Zhang, Xu Liu and Xiang Hao
Nanomaterials 2021, 11(8), 2145; https://doi.org/10.3390/nano11082145 - 23 Aug 2021
Cited by 5 | Viewed by 3432
Abstract
Dichroic circular polarizers (DCP) represent an important group of optical filters that transfer only that part of the incident light with the desired polarization state and absorb the remainder. However, DCPs are usually bulky and exhibit significant optical loss. Moreover, the integration of [...] Read more.
Dichroic circular polarizers (DCP) represent an important group of optical filters that transfer only that part of the incident light with the desired polarization state and absorb the remainder. However, DCPs are usually bulky and exhibit significant optical loss. Moreover, the integration of these kinds of DCP devices can be difficult and costly as different compositions of chemicals are needed to achieve the desired polarization status. Circular polarizers based on metasurfaces require only thin films in the order of hundreds of nanometers but are limited by their sensitivity to angle of incidence. Furthermore, few existing solutions offer broadband operation in the visible range. By using computational simulations, this paper proposes and analyses a plasmonic DCP structure operating in the visible, from 400 nm to 700 nm which overcomes these drawbacks. The resulting circular dichroism transmission (CDT) is more than 0.9, and the maximum transmission efficiency is greater than 78% at visible wavelengths. These CDT characteristics are largely independent of angle of incidence up to angles of 80 degrees. Full article
(This article belongs to the Special Issue Synthesis and Applications of Nanomaterial-Based Probes for Bio-Imaging)
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16 pages, 7099 KiB  
Article
Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study
by Xiaohui Nan, Wenjia Lai, Dan Li, Jiesheng Tian, Zhiyuan Hu and Qiaojun Fang
Nanomaterials 2021, 11(5), 1235; https://doi.org/10.3390/nano11051235 - 7 May 2021
Cited by 17 | Viewed by 2028
Abstract
Derived from magnetotactic bacteria (MTB), magnetosomes consist of magnetite crystals enclosed within a lipid bilayer membrane and are known to possess advantages over artificially synthesized nanoparticles because of the narrow size distribution, uniform morphology, high purity and crystallinity, single magnetic domain, good biocompatibility, [...] Read more.
Derived from magnetotactic bacteria (MTB), magnetosomes consist of magnetite crystals enclosed within a lipid bilayer membrane and are known to possess advantages over artificially synthesized nanoparticles because of the narrow size distribution, uniform morphology, high purity and crystallinity, single magnetic domain, good biocompatibility, and easy surface modification. These unique properties have increasingly attracted researchers to apply bacterial magnetosomes (BMs) in the fields of biology and medicine as MRI imaging contrast agents. Due to the concern of biosafety, a long-term follow-up of the distribution and clearance of BMs after entering the body is necessary. In this study, we tracked changes of BMs in major organs of mice up to 135 days after intravenous injection using a combination of several techniques. We not only confirmed the liver as the well-known targeted organs of BMs, but also found that BMs accumulated in the spleen. Besides, two major elimination paths, as well as the approximate length of time for BMs to be cleared from the mice, were revealed. Together, the results not only confirm that BMs have high biocompatibility, but also provide a long-term in-vivo assessment which may further help to forward the clinical applications of BMs as an MRI contrast agent. Full article
(This article belongs to the Special Issue Synthesis and Applications of Nanomaterial-Based Probes for Bio-Imaging)
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Review

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16 pages, 32443 KiB  
Review
Fluorescent Probes for STED Optical Nanoscopy
by Sejoo Jeong, Jerker Widengren and Jong-Chan Lee
Nanomaterials 2022, 12(1), 21; https://doi.org/10.3390/nano12010021 - 22 Dec 2021
Cited by 15 | Viewed by 4857
Abstract
Progress in developing fluorescent probes, such as fluorescent proteins, organic dyes, and fluorescent nanoparticles, is inseparable from the advancement in optical fluorescence microscopy. Super-resolution microscopy, or optical nanoscopy, overcame the far-field optical resolution limit, known as Abbe’s diffraction limit, by taking advantage of [...] Read more.
Progress in developing fluorescent probes, such as fluorescent proteins, organic dyes, and fluorescent nanoparticles, is inseparable from the advancement in optical fluorescence microscopy. Super-resolution microscopy, or optical nanoscopy, overcame the far-field optical resolution limit, known as Abbe’s diffraction limit, by taking advantage of the photophysical properties of fluorescent probes. Therefore, fluorescent probes for super-resolution microscopy should meet the new requirements in the probes’ photophysical and photochemical properties. STED optical nanoscopy achieves super-resolution by depleting excited fluorophores at the periphery of an excitation laser beam using a depletion beam with a hollow core. An ideal fluorescent probe for STED nanoscopy must meet specific photophysical and photochemical properties, including high photostability, depletability at the depletion wavelength, low adverse excitability, and biocompatibility. This review introduces the requirements of fluorescent probes for STED nanoscopy and discusses the recent progress in the development of fluorescent probes, such as fluorescent proteins, organic dyes, and fluorescent nanoparticles, for the STED nanoscopy. The strengths and the limitations of the fluorescent probes are analyzed in detail. Full article
(This article belongs to the Special Issue Synthesis and Applications of Nanomaterial-Based Probes for Bio-Imaging)
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