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Nanomaterials
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Noble Metal Nanomaterials for Biomedical Applications
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Noble Metal Nanomaterials for Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (1 September 2022) | Viewed by 3114

Special Issue Editors

Prof. Dr. Yang Liu

E-Mail Website
Guest Editor
Department of Chemistry, Tsinghua University, Beijing 100084, China
Interests: electroanalytical chemistry; biosensor; nanoelectrochemistry; nanostructured interface; electrochemiluminscence
Dr. Zhenyu Lin

E-Mail Website
Guest Editor
College of Chemistry, Fuzhou University, Fuzhou 350108, China
Interests: development of accurate detection technology for disease markers; application of sensors in food and environmental analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Noble metal nanomaterials, such as gold-based nanomaterials, silver-based nanomaterials, platinum-based nanomaterials exhibit great potential in biomedical applications, such as biosensors, bio-imaging, drug delivery, and nanomedicine. This research topic aims to gather new developments, comprehensive studies, and future trends in using noble metal nanomaterials to solve various biomedical problems. Original researches are welcome from multidisciplinary research fields, with a focus on topics including, but not limited to:

  1. Synthesis, characterization, and biomedical applications of noble metal nanomaterials;
  2. Development of different types of noble metal nanomaterials that deals with enormous potential for advanced medical and clinical applications;
  3. Detection of tumor markers including exosomes, nucleic acids, protein markers, and so on;
  4. Early diagnosis of various diseases, such as blood disease, infectious disease, cancers;
  5. Basic and clinical methods, strategies, related mechanisms, machine learning, medical imaging, and so on.

Prof. Dr. Yang Liu
Dr. Zhenyu Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterial
  • biomedical applications
  • imaging
  • machine learning
  • cancer
  • blood disease
  • infectious disease
  • drug delivery
  • diagnose
  • tumor markers
  • nanomedicine

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Published Papers (2 papers)

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16 pages, 4398 KiB  
Article
Biodistribution of Multimodal Gold Nanoclusters Designed for Photoluminescence-SPECT/CT Imaging and Diagnostic
by Greta Jarockyte, Marius Stasys, Vilius Poderys, Kornelija Buivydaite, Marijus Pleckaitis, Danute Bulotiene, Marija Matulionyte, Vitalijus Karabanovas and Ricardas Rotomskis
Nanomaterials 2022, 12(19), 3259; https://doi.org/10.3390/nano12193259 - 20 Sep 2022
Cited by 3 | Viewed by 1841
Abstract
Highly biocompatible nanostructures for multimodality imaging are critical for clinical diagnostics improvements in the future. Combining optical imaging with other techniques may lead to important advances in diagnostics. The purpose of such a system would be to combine the individual advantages of each [...] Read more.
Highly biocompatible nanostructures for multimodality imaging are critical for clinical diagnostics improvements in the future. Combining optical imaging with other techniques may lead to important advances in diagnostics. The purpose of such a system would be to combine the individual advantages of each imaging method to provide reliable and accurate information at the site of the disease bypassing the limitations of each. The aim of the presented study was to evaluate biodistribution of the biocompatible technetium-99m labelled bovine serum albumin–gold nanoclusters (99mTc-BSA-Au NCs) as photoluminescence-SPECT/CT agent in experimental animals. It was verified spectroscopically that radiolabelling with 99mTc does not influence the optical properties of BSA-Au NCs within the synthesized 99mTc-BSA-Au NCs bioconjugates. Biodistribution imaging of the 99mTc-BSA-Au NCs in Wistar rats was performed using a clinical SPECT/CT system. In vivo imaging of Wistar rats demonstrated intense cardiac blood pool activity, as well as rapid blood clearance and accumulation in the kidneys, liver, and urinary bladder. Confocal images of kidney, liver and spleen tissues revealed no visible uptake indicating that the circulation lifetime of 99mTc-BSA-Au NCs in the bloodstream might be too short for accumulation in these tissues. The cellular uptake of 99mTc-BSA-Au NCs in kidney cells was also delayed and substantial accumulation was observed only after 24-h incubation. Based on our experiments, it was concluded that 99mTc-BSA-Au NCs could be used as a contrast agent and shows promise as potential diagnostic agents for bloodstream imaging of the excretory organs in vivo. Full article
(This article belongs to the Special Issue Noble Metal Nanomaterials for Biomedical Applications)
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9 pages, 3680 KiB  
Article
Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical Applications
by Juanjuan Guo, Yang Xu, Caili Fu and Longhua Guo
Nanomaterials 2021, 11(12), 3250; https://doi.org/10.3390/nano11123250 - 30 Nov 2021
Cited by 4 | Viewed by 2330
Abstract
Surface-enhanced Raman spectroscopy (SERS) has been proven to be a promising analytical technique with sensitivity at the single-molecule level. However, one of the key problems preventing its real-world application lies in the great challenges that are encountered in the preparation of large-scale, reproducible, [...] Read more.
Surface-enhanced Raman spectroscopy (SERS) has been proven to be a promising analytical technique with sensitivity at the single-molecule level. However, one of the key problems preventing its real-world application lies in the great challenges that are encountered in the preparation of large-scale, reproducible, and highly sensitive SERS-active substrates. In this work, a new strategy is developed to fabricate an Ag collide SERS substrate by using cetyltrimethylammonium bromide (CTAB) as a connection agent. The developed SERS substrate can be developed on a large scale and is highly efficient, and it has high-density “hot spots” that enhance the yield enormously. We employed 4-methylbenzenethiol(4-MBT) as the SERS probe due to the strong Ag–S linkage. The SERS enhancement factor (EF) was calculated to be ~2.6 × 106. The efficacy of the proposed substrate is demonstrated for the detection of malachite green (MG) as an example. The limit of detection (LOD) for the MG assay is brought down to 1.0 × 10−11 M, and the relative standard deviation (RSD) for the intensity of the main Raman vibration modes (1620, 1038 cm−1) is less than 20%. Full article
(This article belongs to the Special Issue Noble Metal Nanomaterials for Biomedical Applications)
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