Biomarkers of Alpha-Synuclein Pathology
A special issue of NeuroSci (ISSN 2673-4087).
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3090
Special Issue Editor
Special Issue Information
Dear Colleagues,
Alpha-synuclein (a-syn) plays a key role in the pathology of Parkinson’s disease (PD), dementia with Lewy bodies (DLB), Multiple system atrophy (MSA), and other diseases. However, we are still short of biomarkers for alpha-synuclein pathology and its progression in living people. There are yet no cures for these diseases and biomarkers that can direct future therapies are urgently needed.
In PD, total a-syn levels in cerebrospinal fluid (CSF) tend to be lower compared to controls. However, inconsistent findings and a considerable interindividual variability of a-syn levels are limiting its diagnostic and prognostic value. This highlights the need for more refined a-syn biomarkers. Posttranslational modifications of a-syn and oligomeric a-syn species, alone or in combination with other markers, in CSF or other sample types, may prove to be valuable biomarker candidates. Recently, a qualitative assay for aggregation-prone a-syn with high sensitivity and specificity for synucleinopathies has emerged, opening for pre-symptomatic detection of a-syn pathology.
This special issue aims to gather studies of potential biomarkers of a-syn pathology in PD, DLB, MSA, and related diseases with emphasis on diagnostic and prognostic value, and the use of non-invasive patient samples.
Dr. Johannes Lange
Guest Editor
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Keywords
- alpha-synuclein
- Parkinson’s disease
- dementia with Lewy bodies, Multiple system atrophy
- neurodegeneration
- biomarker
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