New Perspectives on Dietary Iron and Human Health

Dear Colleagues,

In mammals, appropriate levels of dietary iron as well as its sufficient absorption at the duodenum are critical for maintaining systemic iron balance. With respect to human health, the management of iron-related disorders requires new strategies as current therapies still rely on iron supplementation or chelation methods. Physiologically, iron homeostasis is tightly controlled by the hepcidin–ferroportin axis. Essentially, every form of iron disorder, resulting either due to iron deficiency or overload, is associated with the dysregulation of this axis. Recent discoveries suggest that additional pathways/mechanisms such as hypoxia-inducible factor (HIF), ferritinophagy, ferroptosis and gut microbial metabolites can be considered therapeutic targets for not only iron-related disorders, but also for a wide range of diseases involving the gastro-intestinal tract (GIT) and beyond. 

This Special Issue, entitled “New Perspectives on Dietary Iron and Human Health”, will focus on the aspects of nutritional as well as genetic aspects of iron-related pathophysiologies relevant to human health, related but not limited to, the following: a) novel approaches for treating iron-related disorders; b) the role of gut microbiota and microbial metabolites; c) ferroptosis; and d) cancers, including CRC (colorectal cancer) and beyond.

This Special Issue of Nutrients entitled “New Perspectives on Dietary Iron and Human Health” welcomes original research and reviews of the literature concerning this important topic.

Dr. Nupur Das
Guest Editor

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• intestinal iron absorption
• intestinal HIF regulation
• ferritinophagy
• nutritional aspect of iron homeostasis
• hereditary disorders of iron absorption
• gut microbiota