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Nutrients
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The Role of Dietary Antioxidants in Healthy Aging
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The Role of Dietary Antioxidants in Healthy Aging

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 10234

Special Issue Editor

Dr. Rocco Rossano

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Guest Editor
Department of Sciences, University of Basilicata, 85100 Potenza, Italy
Interests: markers of oxidative stress; dietary antioxidants; carotenoids; polyphenols; vitamins; physiological aging

Special Issue Information

Dear Colleagues,

The process of aging is characterized by progressive functional and structural decline of the whole organism, leading to death. Oxidative stress, a condition occurring when the production of reactive oxygen species overcomes the cellular antioxidant defenses, is a common marker of aging. To help the organism to reduce oxidative damage it is necessary to enrich the diet with antioxidants contained in food. Dietary molecules such as polyphenols, carotenoids and some vitamins are bioactive compounds found in vegetables, fruits, wine, spices and herbs, and are well known for their antioxidant and radical scavenging activity. In recent decades, interest in studying the relationship between diet and aging has grown and it is now established that some antioxidants extend the lifespan in various aging models. The purpose of this Special Issue is to collect and showcase recent findings on the mechanisms by which these molecules can prolong the lifespan and promote healthy aging, with the objective of advancing knowledge in this area. Thus, it is with great pleasure that I invite scientists to take part in this Special Issue with manuscripts describing original research or reviewing the scientific literature on this topic.

Dr. Rocco Rossano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • markers of oxidative stress
  • dietary antioxidants
  • carotenoids
  • polyphenols
  • vitamins
  • physiological aging
  • age-related disorders
  • modulation of oxidative mechanisms
  • healthy aging

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Published Papers (2 papers)

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17 pages, 4312 KiB  
Article
Regular Supplementation with Antioxidants Rescues Doxorubicin-Induced Bone Deformities and Mineralization Delay in Zebrafish
by Sunil Poudel, Gil Martins, M. Leonor Cancela and Paulo J. Gavaia
Nutrients 2022, 14(23), 4959; https://doi.org/10.3390/nu14234959 - 23 Nov 2022
Cited by 5 | Viewed by 2125
Abstract
Osteoporosis is characterized by an abnormal bone structure with low bone mass and degradation of microarchitecture. Oxidative stress induces imbalances in osteoblast and osteoclast activity, leading to bone degradation, a primary cause of secondary osteoporosis. Doxorubicin (DOX) is a widely used chemotherapy drug [...] Read more.
Osteoporosis is characterized by an abnormal bone structure with low bone mass and degradation of microarchitecture. Oxidative stress induces imbalances in osteoblast and osteoclast activity, leading to bone degradation, a primary cause of secondary osteoporosis. Doxorubicin (DOX) is a widely used chemotherapy drug for treating cancer, known to induce secondary osteoporosis. The mechanism underlying DOX-induced bone loss is still not fully understood, but one of the relevant mechanisms is through a massive accumulation of reactive oxygen and nitrogen species (i.e., ROS and NOS) leading to oxidative stress. We investigated the effects of antioxidants Resveratrol and MitoTEMPO on DOX-induced bone impairment using the zebrafish model. DOX was shown to increase mortality, promote skeletal deformities, induce alterations on intestinal villi, impair growth and mineralization and significantly downregulate osteoblast differentiation markers osteocalcin 2 and osterix/sp7. Lipid peroxidation was significantly increased in DOX-supplemented groups as compared to control and antioxidants, suggesting ROS formation as one of the key factors for DOX-induced bone loss. Furthermore, DOX affected mineral contents, suggesting an altered mineral metabolism. However, upon supplementation with antioxidants, DOX-induced effects on mineral content were rescued. Our data show that supplementation with antioxidants effectively improves the overall growth and mineralization in zebrafish and counteracts DOX-induced bone anomalies. Full article
(This article belongs to the Special Issue The Role of Dietary Antioxidants in Healthy Aging)
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Review

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23 pages, 2738 KiB  
Review
Antioxidant Compounds from Edible Mushrooms as Potential Candidates for Treating Age-Related Neurodegenerative Diseases
by Grazia Maria Liuzzi, Tania Petraglia, Tiziana Latronico, Aniello Crescenzi and Rocco Rossano
Nutrients 2023, 15(8), 1913; https://doi.org/10.3390/nu15081913 - 15 Apr 2023
Cited by 26 | Viewed by 7273
Abstract
The last century has seen an increase in our life expectancy. As a result, various age-related diseases, such as neurodegenerative diseases (NDs), have emerged, representing new challenges to society. Oxidative stress (OS), a condition of redox imbalance resulting from excessive production of reactive [...] Read more.
The last century has seen an increase in our life expectancy. As a result, various age-related diseases, such as neurodegenerative diseases (NDs), have emerged, representing new challenges to society. Oxidative stress (OS), a condition of redox imbalance resulting from excessive production of reactive oxygen species, represents a common feature that characterizes the brains of elderly people, thus contributing to NDs. Consequently, antioxidant supplementation or dietary intake of antioxidant-containing foods could represent an effective preventive and therapeutic intervention to maintain the integrity and survival of neurons and to counteract the neurodegenerative pathologies associated with aging. Food contains numerous bioactive molecules with beneficial actions for human health. To this purpose, a wide range of edible mushrooms have been reported to produce different antioxidant compounds such as phenolics, flavonoids, polysaccharides, vitamins, carotenoids, ergothioneine, and others, which might be used for dietary supplementation to enhance antioxidant defenses and, consequently, the prevention of age-related neurological diseases. In this review, we summarized the role of oxidative stress in age-related NDs, focusing on the current knowledge of the antioxidant compounds present in edible mushrooms, and highlighting their potential to preserve healthy aging by counteracting age-associated NDs. Full article
(This article belongs to the Special Issue The Role of Dietary Antioxidants in Healthy Aging)
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