Marburg Virus

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 971

Special Issue Editors


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Guest Editor
1. School of Health Systems & Public Health, University of Pretoria, Pretoria 0002, South Africa
2. ICAP, Columbia University, New York, NY, USA
Interests: COVID-19; public health response; public health policy; health systems
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Guest Editor
1. College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda
2. Rwanda Biomedical Centre, Kigali, Rwanda
Interests: infectious diseases; clinical microbiology; tuberculosis; hepatitis

Special Issue Information

Dear Colleagues,

Marburg virus disease (MVD) remains one of the most concerning viral hemorrhagic fevers due to its high mortality rate and limited treatment options. Caused by the Marburg virus (MARV), a member of the Filoviridae family, this disease poses a significant threat to public health, particularly in regions experiencing zoonotic spillover events and outbreaks. MARV infection is characterized by severe clinical presentations, necessitating an in-depth understanding of the virus’s epidemiology, pathogen-host interactions, immune responses, mechanisms of immune evasion, and current insights on vaccine and therapeutics development. This Special Issue on "Marburg Virus" aims to provide a comprehensive platform for current research and insights into all aspects of Marburg virus disease, from epidemiological patterns to advancements in vaccines and therapeutic interventions. Contributions that enhance our understanding of MARV immune responses, host defense mechanisms, and the public health impact are particularly encouraged. We welcome the submission of high-quality original research articles, reviews, and commentaries that address a broad range of topics, including but not limited to epidemiology, pathogen-host interactions, immune response and defense mechanisms, vaccine and therapeutic development, treatment, and public health implications. This issue is intended to serve as a comprehensive resource for researchers, healthcare professionals, and policymakers. We encourage submissions from diverse scientific disciplines, including virology, immunology, epidemiology, and public health.

Dr. Tafadzwa Dzinamarira
Prof. Dr. Claude Mambo Muvunyi
Guest Editors

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Keywords

  • Marburg virus
  • viral hemorrhagic fever
  • epidemiology
  • pathogen-host interaction
  • immune response
  • vaccine development
  • public health

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Published Papers (1 paper)

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Research

17 pages, 2272 KiB  
Article
Genomic Evolution and Phylodynamics of the Species Orthomarburgvirus marburgense (Marburg and Ravn Viruses) to Understand Viral Adaptation and Marburg Virus Disease’s Transmission Dynamics
by Claude Mambo Muvunyi, Nouh Saad Mohamed, Emmanuel Edwar Siddig and Ayman Ahmed
Pathogens 2024, 13(12), 1107; https://doi.org/10.3390/pathogens13121107 - 14 Dec 2024
Viewed by 511
Abstract
In this review, we investigated the genetic diversity and evolutionary dynamics of the Orthomarburgvirus marburgense species that includes both Marburg virus (MARV) and Ravn virus (RAVV). Using sequence data from natural reservoir hosts and human cases reported during outbreaks, we conducted comprehensive analyses [...] Read more.
In this review, we investigated the genetic diversity and evolutionary dynamics of the Orthomarburgvirus marburgense species that includes both Marburg virus (MARV) and Ravn virus (RAVV). Using sequence data from natural reservoir hosts and human cases reported during outbreaks, we conducted comprehensive analyses to explore the genetic variability, constructing haplotype networks at both the genome and gene levels to elucidate the viral dynamics and evolutionary pathways. Our results revealed distinct evolutionary trajectories for MARV and RAVV, with MARV exhibiting higher adaptability across different ecological regions. MARV showed substantial genetic diversity and evidence of varied evolutionary pressures, suggesting an ability to adapt to diverse environments. In contrast, RAVV demonstrated limited genetic diversity, with no detected recombination events, suggesting evolutionary stability. These differences indicate that, while MARV continues to diversify and adapt across regions, RAVV may be constrained in its evolutionary potential, possibly reflecting differing roles within the viral ecology of the Orthomarburgvirus marburgense species. Our analysis explains the evolutionary mechanisms of these viruses, highlighting that MARV is going through evolutionary adaptation for human-to-human transmission, alarmingly underscoring the global concern about MARV causing the next pandemic. However, further transdisciplinary One Health research is warranted to answer some remaining questions including the host range and genetic susceptibility of domestic and wildlife species as well as the role of the biodiversity network in the disease’s ecological dynamics. Full article
(This article belongs to the Special Issue Marburg Virus)
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