Pathogenesis Mechanisms and Antimicrobial Strategies against Multidrug-Resistant Pathogens
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 231
Special Issue Editors
Interests: infection control; antimicrobial resistance; antimicrobial stewardship; refugee health; public health; medical education
Special Issues, Collections and Topics in MDPI journals
Interests: infection control; antimicrobial resistance; antimicrobial stewardship; medical education
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The emergence and spread of multidrug-resistant (MDR) pathogens presents significant clinical challenges and affects health outcomes on a global level. The pathogenesis of infection by MDR pathogens is affected by several factors such as resistance types, virulence mechanisms, host susceptibility, management, etc. In turn, pathogenetic mechanisms have many different implications on microorganism spread, contact precautions, management options, patient outcomes, and healthcare system burden.
In response to MDR pathogens, several antimicrobial strategies are being developed. Novel antibiotics with unique targets and mechanisms are in the pipeline to overcome existing resistance pathways. Combination therapies, utilizing multiple antimicrobials, aim to overcome resistance by attacking pathogens through different angles. The use of novel antimicrobial mechanisms and technological advances such as bacteriophages, targeted agents, and nanoparticle technology offer specific approaches and targeted drug delivery systems to manage infections by MDR pathogens, enhancing the efficacy of existing treatment options.
Tackling the spread of resistance through stewardship programs is equally crucial. These programs encompass multifaceted strategies and practices, focusing on optimizing antibiotic use to minimize the emergence and dissemination of resistance in healthcare settings.
This Special Issue is a collection of laboratory, experimental, and clinical research articles, as well as reviews, related to MDR pathogens (primarily bacteria) and specifically to the pathogenesis of infection, antimicrobial options, and antimicrobial strategies. The ultimate aim is to create a scientific hub of recent advances in successful and novel evidence-driven strategies to control the spread and burden of infections by MDR pathogens.
Dr. Nikolaos Spernovasilis
Dr. Constantinos Tsioutis
Guest Editors
Manuscript Submission Information
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Keywords
- antimicrobial stewardship
- antimicrobial treatment
- bacteriophages
- drug development
- efflux
- enzymes
- immunology
- infection control
- monoclonal antibodies
- multi-drug resistance
- nanoparticles
- pathogenesis
- pathophysiology
- target
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