Research on Arthropod-Borne Viral Diseases

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: closed (20 January 2024) | Viewed by 2020

Special Issue Editor


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Guest Editor
ZOOVIR, Department of Biotechnology, National Institute for Agricultural and Food Research and Technology (INIA-CSIC), 28040 Madrid, Spain
Interests: virology; emerging viruses; zoonoses; arboviruses; flaviviruses; host–virus interaction; pathogenesis; antiviral immunity; vaccines; antivirals; diagnosis; epidemiology; animal and human health

Special Issue Information

Dear Colleagues,

Viral diseases transmitted by vector arthropods represent one of the most important threats to human and animal health in the modern world. For decades, many of these diseases have been endemic to regions with low economic indices, where they constitute serious health problems due to the lack of effective means of control. In addition, these diseases frequently (re)-emerge in areas where they had not previously posed a health problem or where they had already been eradicated. This (re)-emergence is exacerbated by globalization and climate change, which causes the movement and establishment of the vectors and viruses responsible for these diseases.

The control of infectious diseases is based on three fundamental axes: prevention, surveillance, and treatment.

This Special Issue aims to bring together new contributions from the relevant fields of research, both basic and applied, against viral diseases transmitted by arthropod vectors. These articles should focus on increasing our knowledge and control of these viral diseases. In this way, contributions are welcome on the following topics: the virulence mechanisms, epidemiology, and diagnoses of these viruses; host immune-mediated responses and pathogeneses; the development of effective vaccines and antivirals; the development of new tools that can be applied in the research or control of diseases; controlling disease through their interference with vectors.

Dr. Nereida Jiménez de Oya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arthropod-borne viruses
  • vector control
  • host immunity
  • pathogenesis
  • epidemiology
  • vaccines

Published Papers (1 paper)

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Research

19 pages, 1460 KiB  
Article
Differential Gene Expression Pattern of Importin β3 and NS5 in C6/36 Cells Acutely and Persistently Infected with Dengue Virus 2
by María Leticia Ávila-Ramírez, Ana Laura Reyes-Reyes, Rodolfo Gamaliel Avila-Bonilla, Mariana Salas-Benito, Doris Cerecedo, María Esther Ramírez-Moreno, María Elena Villagrán-Herrera, Ricardo Francisco Mercado-Curiel and Juan Santiago Salas-Benito
Pathogens 2023, 12(2), 191; https://doi.org/10.3390/pathogens12020191 - 27 Jan 2023
Viewed by 1659
Abstract
The establishment of persistent dengue virus infection within the cells of the mosquito vector is an essential requirement for viral transmission to a new human host. The mechanisms involved in the establishment and maintenance of persistent infection are not well understood, but it [...] Read more.
The establishment of persistent dengue virus infection within the cells of the mosquito vector is an essential requirement for viral transmission to a new human host. The mechanisms involved in the establishment and maintenance of persistent infection are not well understood, but it has been suggested that both viral and cellular factors might play an important role. In the present work, we evaluated differential gene expression in Aedes albopictus cells acutely (C6/36-HT) and persistently infected (C6-L) with Dengue virus 2 by cDNA-AFLP. We observed that importin β3 was upregulated in noninfected cells compared with C6-L cells. Using RT-qPCR and plaque assays, we observed that Dengue virus levels in C6-L cells essentially do not vary over time, and peak viral titers in acutely infected cells are observed at 72 and 120 h postinfection. The expression level of importin β3 was higher in acutely infected cells than in persistently infected cells; this correlates with higher levels of NS5 in the nucleus of the cell. The differential pattern of importin β3 expression between acute and persistent infection with Dengue virus 2 could be a mechanism to maintain viral infection over time, reducing the antiviral response of the cell and the viral replicative rate. Full article
(This article belongs to the Special Issue Research on Arthropod-Borne Viral Diseases)
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