Influenza Virus Pathogenesis and Vaccines
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Vaccines and Therapeutic Developments".
Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 1331
Special Issue Editors
Interests: influenza virus; airway epithelial cells; innate immunity; lung repair
Interests: influenza virus; innate immunity; restriction factors; transmission
Interests: immunoglobulins; B and T lymphocyte subpopulations; HIV infection; cytokines; autoimmunity; allergic diseases; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Influenza A viruses (IAVs) are important respiratory pathogens globally. They represent an ever-present threat to human and animal populations, including pigs, birds, and horses. Infection by IAV can have devastating consequences for human and animal health. Variability between IAVs exists in terms of host range or disease severity within the same species. In susceptible hosts, influenza viruses can cause extensive damage to the lung tissue, a result of both direct viral action and exuberant immune responses. Surviving infection requires rapid and coordinated immune and tissue repair programs, ensuring the rapid control of infection and replacement of the damaged tissue. If these programs are not well regulated, chronic lung defects may persist despite viral clearance and apparent clinical recovery. Vaccines against IAVs exist, but their efficacy is often hampered by viral evolution (antigenic shift and drift) and cross-species jumps. Understanding what determines IAV host range and disease severity is crucial to developing vaccines that protect human and animal health against evolving or newly arising IAV strains. The aim of this Special Issue is to publish original papers and reviews on any aspect of influenza virus pathogenesis that not only advances the knowledge of IAV infection biology, but also helps us to better understand the host and viral factors that permit IAV infection and govern disease severity and vaccine efficacy. The knowledge collected here will be an essential steppingstone leading to the development of more efficient vaccines in the future.
Dr. Caroline Chauche
Dr. Rute Maria Pinto
Prof. Dr. Roberto Paganelli
Guest Editors
Manuscript Submission Information
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Keywords
- influenza virus
- pathogenesis
- disease severity
- viral determinants
- immune responses
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