Metabolic Dysfunction in Chagas Cardiomyopathy
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 9628
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chagas disease (CD) is a neglected tropical disease caused by the parasite Trypanosoma cruzi. Approximately 8 million people in Latin America are chronically infected with T. cruzi, and 65–100 million people are living in areas at risk for infection worldwide. Among them, up to 30% develop debilitating and life-threatening symptomatic chronic chagasic cardiomyopathy (CCC). There is a serious knowledge gap in understanding the basis for transition from asymptomatic to symptomatic CCC. Currently, no effective drugs or vaccines exist to prevent or cure CCC. CCC has been mostly studied as an immunological disease, with the last several decades of investigations focused on the roles of inflammatory pathways in CCC pathogenesis. Recently, it has been concluded that the mechanisms underlying the development and progression of CCC are complex and multifactorial, yet the role of cardiac metabolism in the pathogenesis of CCC is still poorly understood. For this Special Issue of Pathogens, we invite you to submit research articles, review articles, short notes, and communications related to molecular and cellular metabolic dysfunctions in the heart, host metabolic deregulation, and immunometabolic alterations in Chagas disease. We look forward to your contribution.
Asso. Prof. Jyothi F Nagajyothi
Guest Editor
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Keywords
- Trypanosoma cruzi
- Chagas cardiomyopathy
- Cardiac/serum metabolism
- Lipid metabolism
- Metabolic stress
- Oxidative and ER stress
- Animal models
- Chagas patients
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