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Pathogens
Special Issues
Continuous Efforts in Understanding and Mitigating Foodborne Viruses
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Continuous Efforts in Understanding and Mitigating Foodborne Viruses

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 7943

Special Issue Editors

Dr. Dan Li

E-Mail Website
Guest Editor
Department of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore, Singapore
Interests: detection and mitigation of foodborne viruses; microbial safety of leafy greens produced in urban agriculture systems
Dr. Dapeng Wang

E-Mail Website
Guest Editor
Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China
Interests: molecular mechanism of interaction between the viruses and food; seasonal dynamic of infectious foodborne viruses in food chain

Special Issue Information

Dear Colleagues,

Foodborne viruses such as human noroviruses, human rotaviruses, hepatitis A virus, hepatitis E virus etc. continue to threat the public health worldwide. Despite of the recent breakthroughs, there are still large discrepancies over multiple aspects of foodborne viruses to be investigated. For the detection of foodborne viruses, the sensitivity stays as a challenge for molecular methods when food matrix in involved. Moreover, it is hard to distinguish the infectious and inactive viruses only based on molecular methods. On the other hand, the difficulty of virus cultivation always pose questions on public health indication of the virus detection results. For the mitigation of foodborne viruses, due to the general high persistence of non-enveloped viruses, most of the non-heat treatment maintaining organoleptic and nutritional properties of foods have rather limited effects over foodborne viruses. Much efforts therefore shall be dedicated in prevention of virus occurrence in food chains. Those will need much more in-depth understanding over the behaviors and transmission of the viruses and socioeconomic collaboration in the food system management and operation.

This special issue intends to update our continuous efforts in understanding and mitigating foodborne viruses from farm to fork. We will specifically welcome studies with novel study methods in their investigations.

Dr. Dan Li
Dr. Dapeng Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • foodborne viruses
  • detection
  • mitigation
  • transmission
  • novelty

Published Papers (3 papers)

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Research

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14 pages, 4019 KiB  
Article
Antigenic Diversity of Human Norovirus Capsid Proteins Based on the Cross-Reactivities of Their Antisera
by Junshan Gao, Yueting Zuo, Liang Xue, Linping Wang, Yanhui Liang, Yueting Jiang, Weicheng Cai, Luobing Meng, Jumei Zhang, Qinghua Ye, Shi Wu, Qihui Gu, Tao Lei and Qingping Wu
Pathogens 2021, 10(8), 986; https://doi.org/10.3390/pathogens10080986 - 5 Aug 2021
Cited by 6 | Viewed by 2238
Abstract
Human norovirus (HuNoV), which is the major causative agent of acute gastroenteritis, has broad antigenic diversity; thus, the development of a broad-spectrum vaccine is challenging. To establish the relationship between viral genetic diversity and antigenic diversity, capsid P proteins and antisera of seven [...] Read more.
Human norovirus (HuNoV), which is the major causative agent of acute gastroenteritis, has broad antigenic diversity; thus, the development of a broad-spectrum vaccine is challenging. To establish the relationship between viral genetic diversity and antigenic diversity, capsid P proteins and antisera of seven GI and 16 GII HuNoV genotypes were analyzed. Enzyme-linked immunosorbent assays showed that HuNoV antisera strongly reacted with the homologous capsid P proteins (with titers > 5 × 104). However, 17 (73.9%) antisera had weak or no cross-reactivity with heterologous genotypes. Interestingly, the GII.5 antiserum cross-reacted with seven (30.4%) capsid P proteins (including pandemic genotypes GII.4 and GII.17), indicating its potential use for HuNoV vaccine development. Moreover, GI.2 and GI.6 antigens reacted widely with heterologous antisera (n ≥ 5). Sequence alignment and phylogenetic analyses of the P proteins revealed conserved regions, which may be responsible for the immune crossover reactivity observed. These findings may be helpful in identifying broad-spectrum epitopes with clinical value for the development of a future vaccine. Full article
(This article belongs to the Special Issue Continuous Efforts in Understanding and Mitigating Foodborne Viruses)
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8 pages, 369 KiB  
Article
No Clinical Symptom Experienced after Consumption of Berry Fruits with Positive RT-qPCR Signals of Human Norovirus
by Mohamad Eshaghi Gorji, Malcolm Turk Hsern Tan, Mitchie Y. Zhao and Dan Li
Pathogens 2021, 10(7), 846; https://doi.org/10.3390/pathogens10070846 - 5 Jul 2021
Cited by 5 | Viewed by 1953
Abstract
Human noroviruses (hNoVs) are the most important foodborne viruses, and soft berries are one of the most common food sources of hNoV outbreaks and contamination. This paper presents a human volunteer study in order to investigate the correlation between molecular detection results of [...] Read more.
Human noroviruses (hNoVs) are the most important foodborne viruses, and soft berries are one of the most common food sources of hNoV outbreaks and contamination. This paper presents a human volunteer study in order to investigate the correlation between molecular detection results of hNoV in berries with the public health risks. The participants with diverse histo-blood group antigens (HBGAs) phenotypes were required to consume self-purchased berries and meanwhile submit aliquots of the products for reverse transcription-quantitative polymerase chain reaction (RT-qPCR) detection. As a result, none of the 20 participants reported any hNoV infection-like symptoms after six independent consumptions (120 consumptions in total). In contrast, within the 68 berry samples with >1% virus recoveries, 28 samples were detected to be positive for hNoV GI and/or GII (the positive rate at 41%). All of the positive signals were below the limit of quantification (<120 genome copies/g) except one fresh strawberry sample at 252 genome copies/g. It is expected that this study would contribute to the definition of quantitative standards for risk assessment purposes in the future. Full article
(This article belongs to the Special Issue Continuous Efforts in Understanding and Mitigating Foodborne Viruses)
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Review

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16 pages, 1579 KiB  
Review
Advances and Future Perspective on Detection Technology of Human Norovirus
by Nan Wang, Guiying Pan, Ping Liu, Shaofeng Rong, Zhiyong Gao and Qianqian Li
Pathogens 2021, 10(11), 1383; https://doi.org/10.3390/pathogens10111383 - 26 Oct 2021
Cited by 8 | Viewed by 2697
Abstract
Human norovirus (HuNoV) is a food-borne pathogen that causes acute gastroenteritis in people of all ages worldwide. However, no approved vaccines and antiviral drugs are available at present. Therefore, the development of accurate and rapid detection technologies is important in controlling the outbreak [...] Read more.
Human norovirus (HuNoV) is a food-borne pathogen that causes acute gastroenteritis in people of all ages worldwide. However, no approved vaccines and antiviral drugs are available at present. Therefore, the development of accurate and rapid detection technologies is important in controlling the outbreak of HuNoVs. This paper reviewed the research progress on HuNoV detection, including immunological methods, molecular detection and biosensor technology. Immunological methods and molecular detection technologies are still widely used for HuNoV detection. Furthermore, biosensors will become an emerging developmental direction for the rapid detection of HuNoVs because of their high sensitivity, low cost, easy operation and suitability for onsite detection. Full article
(This article belongs to the Special Issue Continuous Efforts in Understanding and Mitigating Foodborne Viruses)
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