Pathogenic Neisseria: Genomic Epidemiology, Mechanisms of Antimicrobial Resistance and Infection
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 6794
Special Issue Editor
Interests: microbial genomics; genomic epidemiology; public health; antimicrobial resistance; novel mechanisms
Special Issue Information
Dear Colleagues,
The genus Neisseria includes several species that are mostly human commensals that colonize the mucosa. However, mostly two of them, Neisseria meningitidis and Neisseria gonorrhoeae, can cause serious disease in humans. N. meningitidis colonizes the oropharynx, it spreads through saliva and other respiratory secretions and can cause meningitis and severe sepsis. N. gonorrhoeae is a sexually transmitted pathogen that can cause the genitourinary infection gonorrhoea, which can develop complications if left untreated, such as disseminated infections, increased risk of HIV infection and even infertility. It is included in the World Health Organization priority list of pathogens in need of research and development of new antimicrobials because it has developed or acquired antimicrobial resistance (AMR) to every antibiotic used to treat the disease. Treatment options are scarce and there is not a suitable vaccine, thus posing a current threat to public health worldwide. AMR in N. meningitidis is rare and there are suitable vaccines to prevent meningococcal infections but invasive meningococcal disease is life-threatening and progresses rapidly. Genomic approaches are essential to monitor the spread of these pathogens, study outbreaks, transmission chains, detect novel mechanisms of AMR and pathogenicity as well as identify new potential therapeutic targets. The main focus of this Special Issue of Pathogens will be on genetics and genomics of pathogenic Neisseria for epidemiological purposes, the investigation of novel mechanisms of AMR and infection. The scope will mainly be on pathogenic Neisseria, but we will also welcome relevant work on other commensal Neisseria species. Within this scope, we encourage submissions of original research manuscripts, reviews and case reports on:
- Genomic surveillance.
- Investigation of outbreaks and/or transmission chains.
- Antimicrobial resistance.
- Molecular typing.
- Genetic basis of infection.
- Pathogenesis.
- Host–pathogen interaction.
- Novel approaches to study AMR and virulence.
- Novel therapeutic targets.
- Other aspects relevant to the focus of this Special Issue.
The collation of scientific manuscripts of this Special Issue will surely have a significant impact in the field, helping us to understand the mechanisms of infection, AMR, transmission and the spread of Neisseria species using molecular approaches.
Dr. Leonor Sánchez-Busó
Guest Editor
Manuscript Submission Information
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Keywords
- Neisseria
- genomics
- surveillance
- antimicrobial resistance
- pathogenesis
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