Proteobacteria: A Common Factor in Human Diseases

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 6935

Special Issue Editor


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Guest Editor
University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
Interests: Inflammatory Bowel Disease; Probiotics Microbial Ecology; Gastrointestinal Diseases; Liver Diseases; Food Microbiology

Special Issue Information

Dear Colleagues,

Proteobacteria is a major phylum of Gram-negative bacteria that includes a wide variety of pathogenic genera, such as Escherichia, Salmonella, Vibrio, Helicobacter, Yersinia, and Legionella, to name but a few. Other examples of Proteobacteria are free-living (nonparasitic) and include many of the bacteria responsible for nitrogen fixation. All Proteobacteria are Gram-negative (though some may stain Gram-positive or be Gram-variable in practice), with an outer membrane mainly composed of lipopolysaccharides. In addition, various modes of metabolism are observed for Proteobacteria. While most members are facultatively or obligately anaerobic, chemolithoautotrophic, and heterotrophic, numerous exceptions occur. A variety of genera, which are not closely related to each other, convert energy from light through photosynthesis. Proteobacteria can be further subdivided into classes of Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Deltaproteobacteria, Epsilonproteobacteria, and Zetaproteobacteria.

Proteobacteria are associated not only with intestinal but also extraintestinal diseases. Moreover, studies also suggest a role in lung diseases, such as asthma and chronic obstructive pulmonary disease, but the evidence regarding this remains scant. Furthermore, Proteobacteria are also associated with an imbalance in microbiota of the lower reproductive tract of women.

This Special Issue is dedicated to Proteobacteria. Submissions from researchers investigating Proteobacteria and in relation to various outcomes are welcomed. The aim is to provide state-of-the art summaries of current knowledge and explore emerging developments in the mechanisms between dysbiosis, in particular, where Proteobacteria are implicated in diseases. We look forward to receiving your contributions.

Prof. Loris Lopetuso
Guest Editor

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Keywords

  • Proteobacteria
  • Gram-negative bacteria
  • metabolic disorders
  • inflammatory bowel disease
  • Proteobacteria-related diseases

Published Papers (1 paper)

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Research

11 pages, 1762 KiB  
Communication
A Comprehensive Evaluation of Enterobacteriaceae Primer Sets for Analysis of Host-Associated Microbiota
by Carolina N. Resendiz-Nava, Hilda V. Silva-Rojas, Angel Rebollar-Alviter, Dulce M. Rivera-Pastrana, Edmundo M. Mercado-Silva and Gerardo M. Nava
Pathogens 2022, 11(1), 17; https://doi.org/10.3390/pathogens11010017 - 23 Dec 2021
Cited by 6 | Viewed by 3755
Abstract
Enterobacteriaceae is one of the most important bacterial groups within the Proteobacteria phylum. This bacterial group includes pathogens, commensal and beneficial populations. Numerous 16S rRNA gene PCR-based assays have been designed to analyze Enterobacteriaceae diversity and relative abundance, and, to the best of [...] Read more.
Enterobacteriaceae is one of the most important bacterial groups within the Proteobacteria phylum. This bacterial group includes pathogens, commensal and beneficial populations. Numerous 16S rRNA gene PCR-based assays have been designed to analyze Enterobacteriaceae diversity and relative abundance, and, to the best of our knowledge, 16 primer pairs have been validated, published and used since 2003. Nonetheless, a comprehensive performance analysis of these primer sets has not yet been carried out. This information is of particular importance due to the recent taxonomic restructuration of Enterobacteriaceae into seven bacterial families. To overcome this lack of information, the identified collection of primer pairs (n = 16) was subjected to primer performance analysis using multiple bioinformatics tools. Herein it was revealed that, based on specificity and coverage of the 16S rRNA gene, these 16 primer sets could be divided into different categories: Enterobacterales-, multi-family-, multi-genus- and Enterobacteriaceae-specific primers. These results highlight the impact of taxonomy changes on performance of molecular assays and data interpretation. Moreover, they underline the urgent need to revise and update the molecular tools used for molecular microbial analyses. Full article
(This article belongs to the Special Issue Proteobacteria: A Common Factor in Human Diseases)
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