Hsp90 Inhibitors: Progress, Challenges, and Opportunities in Drug Discovery and Development
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 165
Special Issue Editors
Interests: structural biology; X-ray crystallography; inorganic chemistry; cancer research; parasitic diseases; neurological disorders; β-lactamases; antibiotic resistance; pteridine reductase; heat shock protein 90; 14-3-3; bioinorganic chemistry; glutaminyl cyclase; bile acid binding protein
Special Issues, Collections and Topics in MDPI journals
Interests: chemical modification of natural compounds; medicinal chemistry; food chemistry; antioxidants; antimicrobials; anti-inflammatory; anticancer; guanidines; organic synthesis; delivery systems; drug resistance
Special Issues, Collections and Topics in MDPI journals
Interests: organic chemistry; organic synthesis; green synthetic methodologies; microwave-assisted organic synthesis; solid phase synthesis; metal catalysis; drug conjugates; targeted drug delivery; anticancer; neurodegenerative disorders; epigenetic modulators
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, “Hsp90 Inhibitors: Progress, Challenges, and Opportunities in Drug Discovery and Development,” offers an in-depth exploration of the latest developments in the field of Hsp90 inhibitors. These compounds have demonstrated significant therapeutic potential in the treatment of a wide range of diseases, including cancer, neurodegenerative diseases, and bacterial and viral infections. Over the years, relevant progress has been made in the discovery and development of Hsp90 inhibitors, but there are still several challenges in this field, including optimizing efficacy and selectivity, understanding resistance mechanisms, and transferring the results to the clinic. This Special Issue brings together original contributions and extensive reviews that illustrate the latest advances, discuss current challenges, and outline future opportunities in the field of Hsp90 inhibitors. We hope that this volume will serve as a reference for scientists and experts in the field interested in contributing to the advancement of the research and development of therapies based on Hsp90 inhibitors.
Dr. Giusy Tassone
Dr. Ilaria D’Agostino
Dr. Samuele Maramai
Guest Editors
Manuscript Submission Information
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Keywords
- Hsp90
- drug discovery
- synthesis
- chaperone
- therapeutic potential
- cancer treatment
- neurodegenerative diseases
- infection resistance mechanisms
- research advancements
- therapeutic development
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