Pharmaceutical Functions of Natural Compounds Derived from Molluscs and Arthropods
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 5163
Special Issue Editor
Special Issue Information
Dear Colleagues,
Molluscs and arthropods are a promising source of bioactive compounds that contribute to favorable adaptations for survival in different environments. Therefore, they are the subject of scientific research with the aim of discovering new antitumor, antimicrobial, and antiviral compounds.
A study of the antitumor properties of active components obtained from hemolymph and mucus demonstrates an antiproliferative effect on cancer cell lines. Compounds in the hemolymph with anticancer activities are hemocyanins, oligomeric oxygen-carrying glycometalloproteins widely used in immunological and clinical applications. These biomacromolecules bind small molecule chemicals, such as drugs, hormones, peptides, polysaccharides, lipids, and oligonucleotides, which, in their pure state, do not elicit a response from the immune system.
Hemocyanins present promising antiviral effects against a number of viruses. The carbohydrate structures and antiviral properties of hemocyanins have been established in the rsearch.
In addition, peptides and glycoproteins with antimicrobial activities against various bacterial strains have been discovered in the hemolymph and mucus of molluscs. They also have a positive effect on neurodegenerative diseases. Due to their broad spectrum of actions, natural antimicrobial peptides are a model for the discovery of new antimicrobial drugs to solve the problem of multidrug resistance in pathogenic microorganisms. Some of the identified biologically active molecules have been developed into pharmaceutical products.
Prof. Dr. Pavlina Dolashka
Guest Editor
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Keywords
- glycoproteins
- antimicrobial peptides
- nanoparticles
- therapeutics
- mass spectrometry
- nanodrugs