Pharmacological Activities and Therapeutic Potential of Novel Drug Derivatives

Dear Colleagues,

In modern science, an increasingly rapid dynamic in the development of pharmacology is observed. The main goal is the discovery and design of new drug derivatives with promising therapeutic efficacy which limit the possibility of unwanted side effects. This Special Issue will focus on advances in synthesizing, evaluating, and applying innovative drug derivatives in various therapeutic areas.This Special Issue aims at gathering original research and review articles focused on pharmacological activities of novel compounds, including highly selective anticancer agents and antimicrobial derivatives capable of overcoming resistance mechanisms. Applying a thorough methodology incorporating in silico calculations, in vitro bioassays, and in vivo preclinical evaluations, this Special Issue elucidates the therapeutic advantages and underlying mechanisms of novel derivatives. Contributions that expand the understanding of the potential of these compounds and demonstrate their applications in medicine are encouraged.Research projects examining the potential of medicinal derivatives in the treatment of chronic conditions such as neurodegenerative diseases, autoimmune disorders, and cardiovascular problems are also a focus of interest.We welcome contributions that explore these aspects from both fundamental and applied perspectives, as well as studies aimed at improving the bioavailability, stability, and therapeutic efficacy of contemporary pharmaceuticals. This Special Issue calls for interdisciplinary research addressing regulatory, ethical, and precision medicine challenges to advance therapeutic development.

Dr. Stoyanka Atanasova
Dr. Vera Gledacheva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.