The 20th Anniversary of Pharmaceuticals—Nanoparticle Interactions with Cells
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: 25 February 2025 | Viewed by 184
Special Issue Editor
Interests: functional liposomes; functional dendritic polymers; nano-sized drug delivery systems; drug targeting; triggered drug release
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The introduction of nanoparticles, and nanotechnology in a more general sense, over the last few decades gave rise to a number of applications that promised—and in several cases delivered—exceptional results, but on the other hand revealed the need for careful monitoring of their presence and their effect(s) on nature and eventually on living organisms. A wide variety of nanoparticles (NPs) with regard to composition, size, shape and reactive functional groups/surface charge are nowadays developed and tested for a variety of potential applications including—but not limited to—catalysis, construction materials, nanoscale electronics, fuel cells, solar cells and displays, as well as biomedical applications such as drug delivery, biological imaging, tissue engineering, antimicrobials/antivirals/antifungals and biosensors.
Their ever-increasing development and production mean that special attention on their impact on the environment and living species must be given in order to gain knowledge on their potential harmful effects, to better understand and, ultimately, predict their overall effect on biological systems. To this end, investigation of their interactions with cells is an essential and critical first step, given that these studies can be performed under well-defined environments and precisely controlled experimental parameters.
In most cases up to now, relevant studies are only limited to the effect of NPs on cellular uptake and cytotoxicity, but it is increasingly realized that future studies must focus on studying the effect of NPs on cellular functions, including, for instance, cell stress, cell mechanics, subcellular internalization, and the cellular fate of NPs. In addition, further knowledge must be acquired on the ability of localized NPs either intracellularly or in the extracellular milieu to impair cell-cell adhesion, cell-matrix adhesion and cell migration.
During the past few years, investigations of this kind have been carried out and it is the aim of this Special Issue to encourage and support such efforts by providing a forum for the exchange of scientific results and ideas.
Dr. Dimitris Tsiourvas
Guest Editor
Manuscript Submission Information
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Keywords
- cellular interactions
- cell-membrane penetration
- cell internalization
- cellular uptake
- endocytosis
- biomembranes
- computational modeling
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