Pharmacotherapy of Gastric Cancer

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1309

Special Issue Editor


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Guest Editor
Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
Interests: gastric cancer; public health problem; chemotherapy failures; immunotherapy's new hope; peritoneal carcinomatosis risk; life after gastric cancer surgery

Special Issue Information

Dear Colleagues,

Gastric cancer is a public health problem. The number of gastric cancer patients has increased. But what is the cause? Why hasn't Helicobacter pylori been eradicated so far? Current protocols recommend chemotherapy before surgery. But if the disease progresses under chemotherapy and surgical resection cannot be carried out due to the risk of peritoneal carcinomatosis, what pharmaceutical solutions are available? These are the questions we want to discuss in this Special Issue.

Dr. Gabriel Samasca
Guest Editor

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Keywords

  • chemotherapy
  • immunotherapy
  • peritoneal carcinomatosis
  • microbiota
  • pharmaceutical solutions

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Published Papers (1 paper)

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14 pages, 517 KiB  
Review
A New Medical Evaluation for Gastric Cancer Patients to Increase the Success Rate of Immunotherapy: A 2024 Update
by Gabriel Samasca, Claudia Burz, Irena Pintea, Adriana Muntean, Diana Deleanu, Iulia Lupan and Vasile Bintintan
Pharmaceuticals 2024, 17(9), 1121; https://doi.org/10.3390/ph17091121 - 24 Aug 2024
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Abstract
Researchers have performed numerous studies on immunotherapy because of the high death rate associated with gastric cancer (GC). GC immunotherapy research has made tremendous progress, and we wanted to provide an update on this topic. On the basis of this update, we suggest [...] Read more.
Researchers have performed numerous studies on immunotherapy because of the high death rate associated with gastric cancer (GC). GC immunotherapy research has made tremendous progress, and we wanted to provide an update on this topic. On the basis of this update, we suggest performing a new medical evaluation before initiating immunotherapy in patients with GC to increase the success rate of immunotherapies. We propose that before patients start GC immunotherapy, they should be evaluated and given a score of one to two points for the following factors: immunopathological features, molecular and genomic features, potential consequences for bacterial pathogens, potential immunotherapeutic resistance and hyperprogressive illness, and the potential to use biomarkers to gauge their prognosis and immunotherapy responses to optimize immunotherapy following surgery. The proposed scoring system could also help in the diagnosis of GC. With all the advances in genetics, immunology, and microbiology, the diagnosis of GC could be improved, not changed. Currently, patients diagnosed with GC undergo surgical resection as the only permanent solution. Patients who meet the maximum score from the presented proposal could be eligible immediately after diagnosis for immunotherapy. Therefore, immunotherapy could be a first-line option for clinicians. Full article
(This article belongs to the Special Issue Pharmacotherapy of Gastric Cancer)
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