Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Neuroprotective Agents and Therapeutics
edited by Yunna Kim and
submission deadline 30 Sep 2026 | Viewed by 162 | Submission Open
Keywords: neuroprotection; neurodegenerative diseases; neurological disorders; drug discovery; therapeutic development; neuroinflammation; oxidative stress; mitochondrial dysfunction; synaptic plasticity; blood– brain barrier
(This special issue belongs to the Section Pharmacology)
Potential Therapeutic Roles of RNA and Protein Molecules in Cardiovascular Diseases
edited by Wei Zhang
submission deadline 30 Sep 2026 | Viewed by 161 | Submission Open
Keywords: cardiovascular diseases; heart failure; hypercholesterolemia and dyslipidemia; novel therapeutic targets; RNA therapeutics; non-coding RNAs; mRNA therapy; targeted delivery systems; nanomedicine; precision cardiovascular medicine
(This special issue belongs to the Section Biopharmaceuticals)
Integrating Precision Nutrition with Pharmacological Therapies: Mechanisms, Clinical Outcomes, and Therapeutic Efficiency
edited by
submission deadline 30 Sep 2026 | Viewed by 143 | Submission Open
Keywords: precision nutrition; Foods for Special Medical Purposes (FSMPs); nutritional support; drug– nutrient interactions; pharmacokinetics; pharmacodynamics; personalized medicine; pharmacological therapies; cost-effectiveness; integrated care
(This special issue belongs to the Section Pharmacology)
Nanoplatforms for Enhanced Cancer Therapy
edited by Sang Bong Lee
submission deadline 30 Sep 2026 | Viewed by 132 | Submission Open
Keywords: nanoplatforms; cancer therapy; cell tracking; molecular imaging; multimodal imaging; radiation therapy; radionuclide therapy; radiotheranostics targeted drug delivery; nanomedicine; tumor targeting; radiosensitization; radioisotope delivery; theranostics; precision oncology
(This special issue belongs to the Section Pharmaceutical Technology)
Targeting the Proteostasis Network: From Fundamental Mechanisms to Therapeutic Innovation
edited by Jianhui Li and
submission deadline 30 Sep 2026 | Viewed by 114 | Submission Open
Keywords: ubiquitin– proteasome system; autophagy; protein homeostasis; targeted protein degradation and stabilization; protein quality control; post-translational modifications; cell signaling
(This special issue belongs to the Section Biopharmaceuticals)
Management and Treatment of Cardiometabolic Disorders Across the Lifespan
edited by Pasquale Mone, and Luigi Simone Aversa
submission deadline 5 Oct 2026 | Viewed by 206 | Submission Open
Keywords: cardiometabolic disorders; frailty; diabetes; prediabetes; insulin resistance; hypertension; atherosclerotic cardiovascular disease; obesity; metabolic syndrome; plastic surgery
(This special issue belongs to the Section Pharmacology)
Melatonin Applications in Pharmaceutical Science submission deadline 10 Oct 2026 | Viewed by 441 | Submission Open
Keywords: melatonin; pineal gland; epigenetics; pharmacology; physiology; immunology; pharmaceutics; novel therapies; cancer
(This special issue belongs to the Section Pharmacology)
Chronic Inflammation: Molecular Mechanisms and Precision Biomarkers
edited by and Raul Patrascu
submission deadline 10 Oct 2026 | Viewed by 184 | Submission Open
Keywords: chronic inflammation; molecular mechanisms; precision biomarkers; immunopathology; cytokines; tumor microenvironment; head and neck diseases; personalized medicine; inflammatory pathways; translational research
(This special issue belongs to the Section Medicinal Chemistry)
Natural Pharmacons: Biologically Active Plant-Based Pharmaceuticals—4th Edition submission deadline 15 Oct 2026 | 10 articles | Viewed by 15944 | Submission Open
Keywords: chemical characterization of natural preparations; therapeutic potential of natural matrices in cardiovascular diseases; diabetes; cancer; and neurodegenerative diseases; antimicrobial activity; antioxidant activity; anti-enzymatic activity; anti-inflammatory activity; mechanism of pharmacological actions; structure– activity relationship studies
(This special issue belongs to the Section Natural Products)
Allosteric Drug Design in the AI Era
edited by Lydia Siragusa and
submission deadline 15 Oct 2026 | Viewed by 430 | Submission Open
Keywords: allosteric modulation; artificial intelligence in drug discovery; computational pharmacology; allosteric sites prediction; structure-based drug design
(This special issue belongs to the Section AI in Drug Development)
New Advances in Antiarrhythmic Drugs submission deadline 20 Oct 2026 | 7 articles | Viewed by 23034 | Submission Open
Keywords: antiarrhythmic drugs; ion channel blockers; cardiac action potential; sudden cardiac death; cardiac arrhythmia; proarrhythmic action
(This special issue belongs to the Section Pharmacology)
Advancements in Radiopharmaceutical Theranostics
edited by , Shilpa Sharma and
submission deadline 20 Oct 2026 | 3 articles | Viewed by 2719 | Submission Open
Keywords: radiopharmaceuticals; radiotheranostics; emerging radionuclides; radiometals; image-guided dosimetry; alpha-emitters; PET; SPECT; radioligand therapy; targeted radionuclide therapy
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Next-Generation Targeted Therapy: vNARs, VHH, and Peptides as Drug Carriers and Intracellular Neutralizing Agents submission deadline 20 Oct 2026 | 1 articles | Viewed by 909 | Submission Open
Keywords: vNAR; VHH; peptides; drug delivery; intrabodies; payload; nanotechnology; immunotoxins; phage display; biopanning; single domain antibody; neutralizing agents; intracellular targeting
(This special issue belongs to the Section Pharmacology)
Natural Products in Gut Microbiome Modulation: Mechanisms and Clinical Applications submission deadline 20 Oct 2026 | Viewed by 100 | Submission Open
Keywords: gut microbiome modulation; natural bioactive compounds; microbiome-targeted therapeutics; gut microbiome; human health
(This special issue belongs to the Section Natural Products)
Pharmacotherapy of Thromboembolism submission deadline 25 Oct 2026 | 8 articles | Viewed by 29226 | Submission Open
Keywords: activated factor XI inhibitors; platelet glycoprotein VI antagonists; PAR4 antagonists; PI3K inhibitorslong-term anticoagulation; antiplatelet therapy; novel antithrombotic drugs; anticoagulation-related bleeding; post-vascular procedure-related thrombosis
(This special issue belongs to the Section Pharmacology)
Pharmacovigilance Insights: Addressing Drug Misuse and Enhancing Drug Safety submission deadline 25 Oct 2026 | 10 articles | Viewed by 15954 | Submission Open
Keywords: adverse drug reaction; pharmacovigilance; drug safety; signal detection; risk management
(This special issue belongs to the Section Pharmacology)
Research on Diagnosis, Treatment and Related Microbiota in Gastrointestinal Diseases
edited by and Brigida Barberio
submission deadline 25 Oct 2026 | 3 articles | Viewed by 6140 | Submission Open
Keywords: gut microbiota; inflammatory bowel disease; eosinophilic esophagitis; primary sclerosing cholangitis; metabolic-associated steatotic liver disease; immune checkpoint inhibitor colitis; dysbiosis; prebiotics; probiotics
(This special issue belongs to the Section Medicinal Chemistry)
Tumor Immunopharmacology, 2nd Edition submission deadline 25 Oct 2026 | 3 articles | Viewed by 4126 | Submission Open
Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine; immunoresistance; tumor-infiltrating lymphocytes (TILs); immune escape; immune checkpoint inhibitors; cytokine-based therapies; small molecule immunomodulators; combination therapy; precision oncology; tumor mutational burden (TMB); antibody-dependent cellular cytotoxicity (ADCC ); complement-dependent cytotoxicity (CDC); myeloid-derived suppressor cells (MDSCs)
(This special issue belongs to the Section Pharmacology)
Novel Therapeutic Targets in the Cardiovascular Treatment Landscape
edited by Weida Wu and
submission deadline 25 Oct 2026 | 3 articles | Viewed by 2331 | Submission Open
Keywords: cardiovascular disease; novel therapeutic targets; lipid metabolism; cardiac fibrosis and remodeling; inflammation and immune modulation; Lp(a); heart failure; RNA therapeutics; precision cardiology; cardiomyopathy
(This special issue belongs to the Section Pharmacology)
The Role of Phytochemicals in Aging and Aging-Related Diseases, 2nd Edition submission deadline 25 Oct 2026 | 3 articles | Viewed by 2184 | Submission Open
Keywords: phytochemicals; plant-based diet; dietary supplementation; pharma-nutrition; aging; aging-related diseases; prevention
(This special issue belongs to the Section Natural Products)
Synthesis, In Silico Prediction and Antitumor Activity of Nitrogen Heterocycle-Based Drug Development
edited by Jamerson F. De Oliveira and Paulo André Teixeira de Moraes Gomes
submission deadline 25 Oct 2026 | 2 articles | Viewed by 1744 | Submission Open
Keywords: privileged structures; nitrogen heterocycles; ADMET prediction; cancer biological target; molecular dynamic; computational studies; antitumor activity; in vitro and in vivo studies; SAR of lead compounds; molecular hybridization
(This special issue belongs to the Section Medicinal Chemistry)
Next-Generation Approaches for Cartilage Regeneration
edited by and Liam Morris
submission deadline 25 Oct 2026 | 1 articles | Viewed by 1589 | Submission Open
Keywords: cartilage regeneration; cartilage engineering; bioactive molecules (peptides/proteins/nucleic acids); biomaterials (therapeutic delivery); gene engineering (biopharmaceutical applications); chondrogenic signaling pathways; preclinical/clinical evaluation (cartilage repair); osteoarthritis (therapeutic interventions); therapeutic targets (cartilage repair); translational regenerative medicine
(This special issue belongs to the Section Biopharmaceuticals)
Natural Products for the Treatment of Prostate Cancer submission deadline 25 Oct 2026 | 1 articles | Viewed by 873 | Submission Open
Keywords: prostate cancer; natural compounds; plants; urinary tract infections; supplements; signaling pathways
(This special issue belongs to the Section Natural Products)
Advances in and Perspectives on Oral Drug Delivery submission deadline 25 Oct 2026 | Viewed by 353 | Submission Open
Keywords: enhanced drug delivery; oral route; oral peptide delivery; 3D printing; continuous manufacturing; PBPK modeling; nanocarriers; translational pharmaceutics; low aqueous solubility and low permeability; enhanced oral bioavailability; transporter targeting; emerging materials and excipients in oral delivery; dosage form transition of already marketed drugs; examining herbal or traditional drugs oral delivery; sustained release; nanotechnology; application of cellular components such as exosomes or vesicles for oral delivery; in silico docking for PBPK; nanocarriers; lipid-based formulations; self-emulsifying drug delivery systems (SEDDS); solid dispersions; mucoadhesive systems
(This special issue belongs to the Section Pharmaceutical Technology)
Application and Translational Research of Lanthanide/Nanomaterial-Conjugated Photosensitizers in Photodynamic Therapy
edited by
submission deadline 25 Oct 2026 | Viewed by 229 | Submission Open
Keywords: lanthanide-based nanomaterials; nanomaterial-conjugated photosensitizers; photodynamic therapy (PDT); targeted delivery; upconversion luminescence; preclinical evaluation; translational research; biocompatibility
(This special issue belongs to the Section Pharmaceutical Technology)
Quality Control and Standardization of Plant-Based Pharmaceuticals
edited by and
submission deadline 25 Oct 2026 | Viewed by 159 | Submission Open
Keywords: quality control and standardization of plant-based products; authentication of medicinal plants; phytochemical characterization; secondary marker metabolites; pharmacological validation; safety and toxicological assessment; pharmaceutical formulation; evidence-based herbal medicine; ethnopharmacology; regulatory aspects of herbal medicines; reproducibility in natural products research
(This special issue belongs to the Section Natural Products)
Plant Extracts Regulating Oxidative Stress and Metabolism: Drug Discovery and Repurposing submission deadline 25 Oct 2026 | Viewed by 126 | Submission Open
Keywords: plant extracts; natural compounds; oxidative stress; redox signaling; metabolic regulation; insulin resistance; mitochondrial dysfunction; inflammation; neurodegeneration
(This special issue belongs to the Section Natural Products)
Advances in Antiparasitic Drug Research: 2nd Edition submission deadline 25 Oct 2026 | Viewed by 69 | Submission Open
Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics
(This special issue belongs to the Section Pharmacology)
Advancements in Cardiovascular and Antidiabetic Drug Therapy, 2nd Edition
edited by
submission deadline 27 Oct 2026 | 17 articles | Viewed by 35128 | Submission Open
Keywords: cardiovascular diseases; antidiabetic drugs; pharmacological interventions; sodium– glucose cotransporter 2 inhibitors; PCSK9 inhibitors; obeticholic acid; lipid-lowering agents; heart failure treatment; diabetes management; drug therapy innovations
(This special issue belongs to the Section Pharmacology)
Advances in Biotechnological Formulations for Skin Disorders: Delivery Strategies and Biocompatibility
edited by Marcel Henrique Marcondes Sari, and
submission deadline 27 Oct 2026 | 3 articles | Viewed by 11980 | Submission Open
Keywords: skin disorders; biotechnological formulations; nanocarriers; probiotic-based formulations; natural products; polysaccharides; skin delivery systems; bioactive compounds; antioxidant and anti-inflammatory effects; wound healing; safety and efficacy in skin therapies
(This special issue belongs to the Section Pharmaceutical Technology)
Bioactive Natural Extracts: Advances in Pharmacological and Therapeutic Research submission deadline 30 Oct 2026 | 7 articles | Viewed by 5375 | Submission Open
Keywords: bioactive compounds; natural extracts; pharmacological activity; drug discovery; plant-derived compounds
(This special issue belongs to the Section Natural Products)
Therapeutic Potential of Natural Extracts in Cancer Prevention and Treatment submission deadline 30 Oct 2026 | 2 articles | Viewed by 3307 | Submission Open
Keywords: natural products; anticancer therapeutic potential; cancer chemoprevention; mechanism of action and molecular targets; preclinical and clinical studies
(This special issue belongs to the Section Natural Products)
Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability
edited by Marival Bermejo, and Covadonga Álvarez-Álvarez
submission deadline 30 Oct 2026 | 2 articles | Viewed by 2159 | Submission Open
Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release
(This special issue belongs to the Section Pharmaceutical Technology)
Synthesis and Anticancer Activity of Biologically Active Heterocyclic Compounds
edited by and Rita Vaickelionienė
submission deadline 30 Oct 2026 | 2 articles | Viewed by 2074 | Submission Open
Keywords: heterocyclic compounds; five- or six-membered heterocycles; oxygen- and nitrogen-based heterocycles; sulfur- and nitrogen-based heterocycles; azoles; small molecules; anticancer activity; cell lines; cytotoxicity
(This special issue belongs to the Section Medicinal Chemistry)
Kynurenine Pathway: A Novel Therapeutic Opportunity—2nd Edition submission deadline 30 Oct 2026 | 1 articles | Viewed by 1279 | Submission Open
Keywords: tryptophan catabolism; redox modulation; kynurenines; immunoregulation
(This special issue belongs to the Section Pharmacology)
Targeted Radiopharmaceutical Therapies: Cutting-Edge Advances
edited by Noeen Malik
submission deadline 30 Oct 2026 | Viewed by 291 | Submission Open
Keywords: targeted radiopharmaceutical therapies (TRT); radiopharmaceuticals; radionuclide therapy; molecular radiotherapy; radioisotopes; radiochemistry; isotope production; radionuclide delivery; preclinical evaluation; clinical translation
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Improving Pharmaceutical Formulation and Stability In Silico Methods submission deadline 30 Oct 2026 | Viewed by 95 | Submission Open
Keywords: in silico modeling; drugs and formulations; molecular dynamics; quantum mechanics; discrete element method; computational fluid dynamics; formulation design; dissolution; stability; manufacturing
(This special issue belongs to the Section Pharmaceutical Technology)
Adjuvant Therapies for Cancer Treatment: 2nd Edition
edited by
submission deadline 31 Oct 2026 | 12 articles | Viewed by 96509 | Submission Open
Keywords: drug repurposing; combined therapies; new compounds; drug resistance; chemosensitization; antitumoral strategies
(This special issue belongs to the Section Pharmacology)
NeuroImmunoEndocrinology
edited by , , and Oscar Adelmo Bottasso
submission deadline 31 Oct 2026 | 11 articles | Viewed by 60702 | Submission Open
Keywords: cytokines; neurotransmitters; hormones; infections; antibiotics; antidepressants; antipsychotics; drugs; stress; depression; schizophrenia; immunomodulation
(This special issue belongs to the Section Pharmacology)
Treatment and Molecular Mechanisms of Depression
edited by and Ricieri Mocelin
submission deadline 31 Oct 2026 | 1 articles | Viewed by 5431 | Submission Open
Keywords: major depressive disorder; molecular mechanisms; neurotransmitters; epigenetic; genetic polymorphisms; inflammation; neuroinflammation; pharmacological strategies; drugs; intracellular signaling
(This special issue belongs to the Section Medicinal Chemistry)
Cholinergic Modulation, Anticholinergic Burden, and Neuroprotection: Mechanisms to Therapeutics
edited by and
submission deadline 31 Oct 2026 | 3 articles | Viewed by 4655 | Submission Open
Keywords: scopolamine; anticholinergic burden; cholinergic modulation; cognitive impairment; neuroinflammation; oxidative stress; BBB/drug delivery; PK/PD; biomarkers; network pharmacology; flavonoids/polyphenols; zebrafish models; translational neuroscience; deprescribing
(This special issue belongs to the Section Pharmacology)
Exploring Natural Products with Antioxidant and Anticancer Properties, 2nd Edition submission deadline 31 Oct 2026 | 3 articles | Viewed by 2621 | Submission Open
Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity
(This special issue belongs to the Section Natural Products)
Drug Safety and Risk Management in Clinical Practice: 2nd Edition
edited by Andreea Maria Farcas
submission deadline 31 Oct 2026 | 1 articles | Viewed by 582 | Submission Open
Keywords: drug safety; adverse drug reactions; risk minimization measures; effectiveness of risk minimization measures; drug utilization studies
(This special issue belongs to the Section Pharmacology)
Application of Nuclear Magnetic Resonance (NMR) in Drug Discovery and Development
edited by Vladimir M. Gelev
submission deadline 31 Oct 2026 | Viewed by 414 | Submission Open
Keywords: biomolecular NMR; drug discovery; library screening using NMR; SAR using NMR; fragment-based drug discovery using NMR
(This special issue belongs to the Section Pharmaceutical Technology)
Cholinesterases—Structure, Mechanism, Function and Drug Discovery
edited by
submission deadline 31 Oct 2026 | Viewed by 386 | Submission Open
Keywords: cholinesterases; cholinesterase inhibitors; structure-based design of inhibitors; multi-target ligands; non-cholinergic functions; structure; allosteric sites; mechanism; non-classical functions
(This special issue belongs to the Section Medicinal Chemistry)
Molecular Insights and Clinical Implications in Geriatric Medicine and Drug Development
edited by , , Kornelia Kędziora-Kornatowska and
submission deadline 31 Oct 2026 | Viewed by 319 | Submission Open
Keywords: older adults; age-related diseases; biomarkers; drug development; molecular modeling; computer-aided drug design; geriatrics in laboratory medicine; laboratory tests in older patients; malnutrition diagnostics; test results versus a clinical image of an older patient
(This special issue belongs to the Section Pharmacology)
Novel Cannabinoid Receptor Ligands: Discovery, Pharmacology, and Therapeutic Applications submission deadline 31 Oct 2026 | Viewed by 290 | Submission Open
Keywords: cannabinoid receptor modulators; synthetic cannabinoids; allosteric modulation; biased signaling; covalent ligands; PROTACs; cannabinoid probes; inflammation; CNS disorders; cancer
(This special issue belongs to the Section Pharmacology)
New Structural, Biophysical and Computational Perspectives on the Use of Proteins in Drug Design and Discovery submission deadline 31 Oct 2026 | Viewed by 289 | Submission Open
Keywords: artificial intelligence; bioinformatics; computational modelling; drug discovery and design; functional proteomics; mass spectrometry; molecular dynamics; protein– ligand interactions; structural proteomics; structural biology; target identification and validation
(This special issue belongs to the Section Biopharmaceuticals)
Animal Models in Pharmacological Research: Focusing on Oncology and Related Fields
edited by Nomeda Juodžiukyniene and
submission deadline 31 Oct 2026 | Viewed by 206 | Submission Open
Keywords: animals models; veterinary; oncology; histopathology; tumor microenvironment; translational; immunotherapy; target therapy
(This special issue belongs to the Section Pharmacology)
Pharmaceutical Sciences: Perspectives from Early-Career Investigators submission deadline 31 Oct 2026 | Viewed by 150 | Submission Open
Keywords: pharmaceutical science; drug delivery; AI-assisted drug discovery; computational drug design; nanomedicine; pharmacokinetics; pharmacodynamics; natural products; translational research; early-career researchers
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